Ratiometric Afterglow Luminescent Imaging of Matrix Metalloproteinase‐2 Activity via an Energy Diversion Process DOI

Weijing Huang,

Wenhui Zeng, Zheng Huang

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(26)

Published: April 19, 2024

Abstract Ratiometric afterglow luminescent (AGL) probes are attractive for in vivo imaging due to their high sensitivity and signal self‐calibration function. However, there currently few ratiometric AGL available enzymatic activity living organisms. Here, we present an energy diversion (ED) strategy that enables the design of enzyme‐activated probe (RAG‐RGD) imaging. The ED process provides RAG‐RGD with a radiative transition ‘always on’ 520‐nm (AGL 520 ) cascade three‐step transfer (ET) ‘off‐on’ 710‐nm 710 response specific enzyme. Using matrix metalloproteinase‐2 (MMP‐2) as example, shows significant ~11‐fold increase /AGL toward MMP‐2. This can sensitively detect U87MG brain tumors through MMP‐2 activity, signal‐to‐background ratio deep depth. Furthermore, by utilizing effect imaging, demonstrated strong negative correlation between value size orthotopic tumor, enabling accurate monitoring glioma growth vivo. may be applied other sensitive

Language: Английский

Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy DOI Creative Commons
Hai Xu, Dahee Kim, Yuanyuan Zhao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: March 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Language: Английский

Citations

21
A Self‐Sustaining Near‐Infrared Afterglow Chemiluminophore for High‐Contrast Activatable Imaging DOI

Jieli Zhu,

Wan Chen, Li Yang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(11)

Published: Jan. 22, 2024

Afterglow imaging holds great promise for ultrasensitive bioimaging due to its elimination of autofluorescence. Self-sustaining afterglow molecules (SAMs), which enable all-in-one photon sensitization, chemical defect formation and generation, possess a simplified, reproducible, efficient superiority over commonly used multi-component systems. However, there is lack SAMs, particularly those with much brighter near-infrared (NIR) emission structural flexibility building high-contrast activatable probes. To address these issues, this study the first time reports methylene blue derivative-based self-sustaining agent (SAN-M) NIR chemiluminescence peaking at 710 nm. By leveraging tunability, an nanoprobe (SAN-MO) customized simultaneously fluoro-photoacoustic peroxynitrite (ONOO

Language: Английский

Citations

15
Acidity-activatable upconversion afterglow luminescence cocktail nanoparticles for ultrasensitive in vivo imaging DOI Creative Commons
Yue Jiang, Min Zhao,

Jia Miao

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 8, 2024

Abstract Activatable afterglow luminescence nanoprobes enabling switched “off-on” signals in response to biomarkers have recently emerged achieve reduced unspecific and improved imaging fidelity. However, such always use a biomarker-interrupted energy transfer obtain an activatable signal, which necessitates strict distance requisition between donor acceptor moiety (<10 nm) hence induces low efficiency non-feasibility. Herein, we report organic upconversion cocktail nanoparticles (ALCNs) that instead utilize acidity-manipulated singlet oxygen ( 1 O 2 ) with enlarged thus possess more flexibility signal. After vitro validation of acidity-activated luminescence, ALCNs vivo 4T1-xenograft subcutaneous tumors female mice orthotopic liver male high signal-to-noise ratio (SNR). As representative targeting trial, Bio-ALCNs biotin modification prove the enhanced ability, sensitivity, specificity for pulmonary metastasis tumor via systemic administration mice, also implies potential broad utility diverse design flexibility. Therefore, this study provides innovative general approach better performance than fluorescence imaging.

Language: Английский

Citations

13
A NIR‐II‐Emissive Organic Nanomedicine with Biomimetic Engineering for High‐Contrast Targeted Bioimaging and Multiple Phototherapies of Pancreatic Tumors DOI
Yiwei Wang, Jie Zhang, Yu Wang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

Abstract Recent advances are achieved in the design and development of efficient organic photosensitizers (PSs), especially with fluorescence imaging navigation second near‐infrared (NIR‐II, 1000–1700 nm) region. However, there simply a handful NIR‐II emissive PSs oxygen‐independent capability due to scarcity high‐performance NIR‐responsive materials targeted delivery. Herein, NIR‐II‐emissive nanomedicine biomimetic engineering for multiple phototherapies pancreatic tumors is reported. An A‐D‐A‐type conjugated small‐molecule TPC designed used prepare water‐dispersive nanoparticles, which demonstrated high efficiency type I II photodynamic performances, good photothermal conversion 57%, bright emission quantum yield 9.8% under 808 nm light irradiation. With cancer cell membrane camouflage, high‐resolution bioimaging whole‐body blood vessels tumors. Antitumor experiments tumor elimination biosafety This work versatile enhanced tumor‐targeting superior phototheranostics, providing feasible idea evolution theranostics.

Language: Английский

Citations

9
Imaging-guided companion diagnostics in radiotherapy by monitoring APE1 activity with afterglow and MRI imaging DOI Creative Commons
Renye Yue, Zhe Li, Huiyi Liu

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 27, 2024

Companion diagnostics using biomarkers have gained prominence in guiding radiotherapy. However, biopsy-based techniques fail to account for real-time variations target response and tumor heterogeneity. Herein, we design an activated afterglow/MRI probe as a companion tool dynamically assessing biomarker apurinic/apyrimidinic endonuclease 1(APE1) during radiotherapy vivo. We employ ultrabright afterglow nanoparticles ultrasmall FeMnOx dual contrast agents, significantly broadening signal change range enhancing the sensitivity of APE1 imaging (limit detection: 0.0092 U/mL 0.16 MRI). devise longitudinally transversely subtraction-enhanced (L&T-SEI) strategy markedly enhance MRI signal-to-noise ratio between normal tissue living female mice. The combined facilitate both anatomical functional activity. This enables correlation signals with expression, radiation dosage, intratumor ROS, DNA damage, enabling early prediction outcomes (as 3 h), preceding size reduction (6 days). By monitoring levels, this allows sensitive detection liver organ injury, outperforming histopathological analysis. Furthermore, evaluates expression radiation-induced abscopal effects provides insights into underlying mechanisms, supports development treatment protocols. are promising radiotherapy, but normally detect authors report

Language: Английский

Citations

9
Activatable Porphyrin-Based Sensors, Photosensitizers and Combination Therapeutics DOI Creative Commons
Suritra Bandyopadhyay, Joseph A. Forzano, Musa Dirak

et al.

JACS Au, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Porphyrins, known as the "pigments of life", have evolved from their natural roles into versatile tools for biomedical applications. The development activatable porphyrins has significantly expanded utility, enabling precise responses to a carefully selected target analyte. These advances broadened use in imaging, diagnosis, and therapy. capabilities are driven by activity-based sensing (ABS), which enhances selectivity sensitivity various disease biomarkers. However, design implementation intrinsically complex. This perspective provides an easy-to-follow roadmap that details how such molecules can be developed. Furthermore, we highlight recent progress ABS-modified porphyrins, focusing on specific modifications achieve these remarkable properties across platforms. ongoing evolution holds great promise sophisticated, responsive systems, offering more effective diagnostic therapeutic tools.

Language: Английский

Citations

1
Electrostatic Co‐Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy DOI Creative Commons

Haiqiao Huang,

Yingnan Wu,

Xin He

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging‐guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high‐contrast photoacoustic imaging efficient therapeutic capabilities. In this work, a supramolecular strategy is employed construct molecular pair agent via the direct self‐assembly two cyanines, C5TNa (anionic) Cy‐Et (cationic). The Coulombic interactions between facilitate formation complementary cyanine (C5T‐ET) creation CT‐J‐type aggregates in water. This results completely quenched fluorescence significantly enhances nonradiative deactivation (≈22 ps), leading 3.3‐fold increase photothermal conversion efficiency 7.1‐fold enhancement response compared indocyanine green (ICG). As result, J‐type aggregate demonstrates high capability remarkable antitumor efficacy vivo, highlighting its potential clinical applications. work provides strong experimental evidence superior performance enhancing photosensitization response. It believed will propel advancement controllable dye J‐aggregates contribute practical implementation phototherapy vivo.

Language: Английский

Citations

1
Ratiometric Afterglow Luminescent Imaging of Matrix Metalloproteinase‐2 Activity via an Energy Diversion Process DOI

Weijing Huang,

Wenhui Zeng, Zheng Huang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(26)

Published: April 19, 2024

Ratiometric afterglow luminescent (AGL) probes are attractive for in vivo imaging due to their high sensitivity and signal self-calibration function. However, there currently few ratiometric AGL available enzymatic activity living organisms. Here, we present an energy diversion (ED) strategy that enables the design of enzyme-activated probe (RAG-RGD) imaging. The ED process provides RAG-RGD with a radiative transition 'always on' 520-nm (AGL

Language: Английский

Citations

6
Scalable fabrication of red Room-Temperature phosphorescent materials through molecular doping strategy for versatile applications DOI
Jiaju Shi, Yusheng Zhou, Wen Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 492, P. 152419 - 152419

Published: May 20, 2024

Language: Английский

Citations

5
Reactive oxygen species-mediated organic long-persistent luminophores light up biomedicine: from two-component separated nano-systems to integrated uni-luminophores DOI
Zhe Li, Hong‐Wen Liu, Xiaobing Zhang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

An overview of the recent advances in reactive oxygen species-mediated organic long-persistent luminophores, including their history, working mechanisms, design strategies, and biomedical applications.

Language: Английский

Citations

5