Design strategies for tetrazine fluorogenic probes for bioorthogonal imaging
Chemical Society Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
In
this
review,
recent
progress
in
tetrazine-based
fluorogenic
probes
for
bioorthogonal
chemistry
is
comprehensively
analyzed,
with
a
focus
on
advancements
probe
design
and
their
imaging
applications
molecular
processes
live
cells.
Язык: Английский
Matthew effect: General design strategy of ultra‐fluorogenic nanoprobes with amplified dark–bright states in aggregates
Aggregate,
Год журнала:
2024,
Номер
5(2)
Опубликована: Янв. 4, 2024
Abstract
Fluorescence
imaging,
a
key
technique
in
biological
research,
frequently
utilizes
fluorogenic
probes
for
precise
imaging
living
systems.
Tetrazine
is
an
effective
emission
quencher
probe
designs,
which
can
be
selectively
damaged
upon
bioorthogonal
click
reactions,
leading
to
considerable
enhancement.
Despite
significant
efforts
increase
the
enhancement
ratio
(
I
AC
/
BC
)
of
tetrazine‐functionalized
probes,
influence
molecular
aggregation
on
properties
has
been
largely
overlooked
these
designs.
In
this
study,
we
reveal
that
ultrahigh
realized
aggregate
system
when
tetrazine
paired
with
aggregation‐induced
(AIE)
luminogens.
amplifies
its
quenching
efficiency
and
drastically
reduce
background
emissions.
Subsequent
reactions
damage
trigger
AIE,
considerably
enhanced
.
We
further
showcase
capability
ultra‐fluorogenic
systems
selective
multiple
organelles
cells.
term
unique
fluorogenicity
AIE
luminogen‐quencher
complexes
amplified
dark‐bright
states
as
“Matthew
effect”
emission,
potentially
providing
universal
approach
attain
diverse
Язык: Английский
Multiplex Detection of Biomarkers Empowered by Nanomaterials
Precision Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 21, 2025
Язык: Английский
Applications of Aggregation-Induced Emission Materials in Immunology: From Diagnostics to Immunotherapy
Chemical & Biomedical Imaging,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Aggregation-induced
emission
(AIE)
materials,
due
to
their
unique
ability
significantly
enhance
optical
in
aggregated
states,
have
demonstrated
vast
potential
immunology,
particularly
early
disease
diagnosis
and
immunotherapy.
AIE
materials
can
serve
as
highly
efficient
fluorescent
probes
for
biomarker
detection,
providing
critical
insights
diagnosis.
Additionally,
they
act
cancer
vaccines,
enhancing
the
effectiveness
of
immunotherapy
through
photodynamic
therapy,
photothermal
or
activation
immune
cells.
This
review
highlights
applications
focusing
on
recent
advancements
diagnostics
while
also
discussing
challenges
face
directions
future
development.
Язык: Английский
Conceptually innovative fluorophores for functional bioimaging
Daniela Ceballos-Ávila,
Ixsoyen Vázquez-Sandoval,
Fernanda Ferrusca-Martínez
и другие.
Biosensors and Bioelectronics,
Год журнала:
2024,
Номер
264, С. 116638 - 116638
Опубликована: Авг. 9, 2024
Fluorophore
chemistry
is
at
the
forefront
of
bioimaging,
revolutionizing
visualization
biological
processes
with
unparalleled
precision.
From
serendipitous
discovery
mauveine
in
1856
to
cutting-edge
fluorophore
engineering,
this
field
has
undergone
transformative
evolution.
Today,
synergy
chemistry,
biology,
and
imaging
technologies
produced
diverse,
specialized
fluorophores
that
enhance
brightness,
photostability,
targeting
capabilities.
This
review
delves
into
history
innovation
fluorescent
probes,
showcasing
their
pivotal
role
advancing
our
understanding
cellular
dynamics
disease
mechanisms.
We
highlight
groundbreaking
molecules
applications,
envisioning
future
breakthroughs
promise
redefine
biomedical
research
diagnostics.
Язык: Английский
Fluorogenic Tetrazine Bioorthogonal Probes for Advanced Application in Bioimaging and Biomedicine
Chemical & Biomedical Imaging,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 23, 2024
A
variety
of
bioorthogonal
chemical
tools
have
been
developed
and
widely
used
in
the
study
biological
phenomena
situ.
Tetrazine
chemistry
exhibits
ultrafast
reaction
kinetics,
excellent
biocompatibility,
precise
optical
regulatory
capabilities.
Fluorogenic
tetrazine
probes
achieved
particularly
diverse
applications
bioimaging
disease
diagnosis
treatment.
This
Viewpoint
briefly
introduces
characteristics
advantages
chemistry,
some
design
strategies
fluorogenic
probes,
status
these
to
vivo
imaging,
as
well
Finally,
we
discuss
challenges
propose
future
trends
field
probes.
offers
insights
into
development
new
for
biology
research
drugs.
Язык: Английский