Angewandte Chemie,
Год журнала:
2023,
Номер
136(1)
Опубликована: Ноя. 6, 2023
We
present
the
first
solvent-free,
mechanochemical
protocol
for
a
palladium-catalyzed
Tsuji-Trost
allylation.
This
approach
features
exceptionally
low
catalyst
loadings
(0.5
mol
%),
short
reaction
times
(<90
min),
and
simple
setup,
eliminating
need
air
or
moisture
precautions,
making
process
highly
efficient
environmentally
benign.
introduce
solid,
nontoxic,
easy-to-handle
allyl
trimethylammonium
salts
as
valuable
alternative
to
volatile
hazardous
reagents.
Our
enables
allylation
of
various
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(26)
Опубликована: Фев. 14, 2024
Abstract
This
review
provides
a
comprehensive
overview
of
mono‐alkylation
methodologies
targeting
crucial
nitrogen
moieties
–
amines,
amides,
and
sulfonamides
found
in
organic
building
blocks
pharmaceuticals.
Emphasizing
the
intersection
chemical
precision
with
drug
discovery,
central
challenge
addressed
is
achieving
one‐pot
mono‐selective
short‐chain
N‐alkylations
(methylations,
ethylations,
n
‐propylations),
preventing
undesired
overalkylation.
Additionally,
sustainable,
safe,
benign
alternatives
to
traditional
alkylating
agents,
including
alcohols,
carbon
dioxide,
carboxylic
acids,
nitriles,
alkyl
phosphates,
quaternary
ammonium
salts,
carbonates,
are
explored.
review,
categorized
by
nature
agent,
aids
researchers
selecting
suitable
methods
for
N‐alkylation.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(1)
Опубликована: Ноя. 6, 2023
Abstract
We
present
the
first
solvent‐free,
mechanochemical
protocol
for
a
palladium‐catalyzed
Tsuji–Trost
allylation.
This
approach
features
exceptionally
low
catalyst
loadings
(0.5
mol
%),
short
reaction
times
(<90
min),
and
simple
setup,
eliminating
need
air
or
moisture
precautions,
making
process
highly
efficient
environmentally
benign.
introduce
solid,
nontoxic,
easy‐to‐handle
allyl
trimethylammonium
salts
as
valuable
alternative
to
volatile
hazardous
reagents.
Our
enables
allylation
of
various
O
‐,
N
C
‐nucleophiles
in
yields
up
99
%
even
structurally
complex
bioactive
compounds,
owing
its
mild
conditions
exceptional
functional
group
tolerance.
Green Chemistry,
Год журнала:
2024,
Номер
26(10), С. 5890 - 5899
Опубликована: Янв. 1, 2024
A
novel
approach
utilizing
the
polymer-assisted
grinding
(POLAG)
technique
to
facilitate
regioselective
oxidative
Heck
coupling
of
aryl
boronic
acids
with
electronically
unbiased
olefins
under
solvent-free
conditions
was
presented.
International Journal of Case Studies in Business IT and Education,
Год журнала:
2024,
Номер
unknown, С. 69 - 159
Опубликована: Апрель 19, 2024
Purpose:
The
knowledge-based
segment
of
the
economy
is
referred
to
as
"quaternary
sector,"
which
comprises
businesses
like
information
technology,
telecommunications,
research
and
development,
other
professional
services.
Businesses
in
this
industry
may
find
that
technology-driven
business
analytics
greatly
aids
helping
them
make
data-driven
decisions,
optimize
workflows,
enhance
overall
performance.
Utilizing
technology
analyse
can
significantly
improve
market
trends,
consumer
behaviour,
an
organization's
operational
Through
analysis
data,
companies
more
informed
decisions
support
expansion
competitiveness.
Analytics
tools
assist
identifying
inefficiencies
their
processes
operations
so
they
changes
reduce
expenses,
boost
output,
ultimately
revenue.
Customer
loyalty
satisfaction
rise
a
result
this.
Information
regarding
emerging
technologies
integration
with
data
science
prediction
trends
could
present
chances
for
growth
innovation.
Methodology:
There
are
particular
potential
challenges
Quaternary
sector
because
its
emphasis
on
activities,
innovation,
cutting-edge
technology.
Here,
we
methodical
strategy
using
industry,
allowing
obtain
useful
long-term
planning
calculations.
This
approach
gives
framework
utilizing
analytics.
helps
competitive
advantages
increasingly
environment
by
access
important
insights
spur
Findings/Result:
study
looks
at
how
digital
have
been
used
control
from
birth
present.
Originality/Value:
An
explanation
tech
differs
traditional
within
industry.
It
also
includes
general
design
be
technical
purposes,
it
examines
thirty
recently
submitted
recommendations
related
Tech
Business
industries.
Paper
Type:
Exploratory
research.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(33)
Опубликована: Апрель 8, 2024
Alkylation
reactions
are
pivotal
in
organic
chemistry,
with
wide-ranging
utilization
across
various
fields
of
applied
synthetic
chemistry.
However,
conventional
reagents
employed
alkylations
often
pose
substantial
health
and
exposure
risks.
Quaternary
ammonium
salts
(QAS)
present
a
promising
alternative
for
these
transformations
offering
significantly
reduced
hazards
as
they
non-cancerogenic,
non-mutagenic,
non-flammable,
non-corrosive.
Despite
their
potential,
use
direct
remains
relatively
unexplored.
This
review
outlines
strategies
utilizing
QAS
alkylation
reactions,
providing
researchers
safer
approaches
to
chemical
synthesis.
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
novel
palladium-catalyzed
allylic
C-H
alkylation
of
terminal
olefins
with
3-carboxamide
oxindoles
is
described.
variety
new
3-carboxamide-3-allylation
an
all-carbon
quaternary
center
were
obtained
in
moderate
to
good
yields
(up
99%).
In
addition,
the
asymmetric
version
this
reaction
was
also
explored,
providing
enantioselectivity.
Abstract
This
review
provides
an
overview
on
recent
progress
in
mechanochemical
transition
metal
catalyzed
C─H
functionalization.
Solventless
operation
and
enhanced
reaction
efficiency
makes
synthesis
a
more
sustainable
alternative
to
conventional
approaches.
By
including
comparison
between
methods
solvent‐based
protocols,
this
chemists
with
valuable
insights
into
the
relative
sustainability
of
these
solventless
strategies.
enables
informed
decision‐making
when
selecting
for
functionalization
based
specific
needs.
Moreover,
identifies
existing
gaps
discusses
necessary
steps
establish
it
as
mainstream
approach.
bridging
gaps,
can
further
enhance
utility
adoption
methodologies,
contributing
practices
synthetic
chemistry.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(49)
Опубликована: Авг. 29, 2024
Abstract
30
Seconds
to
success!—The
Wittig
reaction,
a
fundamental
and
extensively
utilized
reaction
in
organic
chemistry,
enables
the
efficient
conversion
of
carbonyl
compounds
olefins
using
phosphonium
salts.
Traditionally,
meticulous
setup,
including
pre‐formation
reactive
ylide
species
via
deprotonation
salt,
is
crucial
for
achieving
high‐yielding
reactions
under
classical
solution‐based
conditions.
In
this
report,
we
present
an
unprecedented
protocol
ultra‐fast
mechanically
induced
solvent‐free
ambient
conditions,
often
eliminating
need
tedious
strict
air
moisture
exclusion.
A
range
aldehydes
ketones
were
reacted
with
diverse
salts
high‐energy
ball
milling
frequently
giving
access
respective
only
seconds.
30
Seconds
to
success!
–
The
Wittig
reaction,
a
fundamental
and
extensively
utilized
reaction
in
organic
chemistry,
enables
the
efficient
conversion
of
carbonyl
compounds
olefins
using
phosphonium
salts.
Traditionally,
meticulous
setup,
including
pre-formation
reactive
ylide
species
via
deprotonation
salt,
is
crucial
for
achieving
high-yielding
reactions
under
classical
solution-based
conditions.
In
this
report,
we
present
an
unprecedented
protocol
ultra-fast
mechanochemically
driven
solvent-free
ambient
conditions,
eliminating
need
tedious
strict
air
moisture
exclusion.
A
range
aldehydes
ketones
were
reacted
with
diverse
salts
high-speed
ball
milling
giving
access
respective
only
seconds.
Abstract
A
mechanochemical,
highly
regioselective
rhodium(III)‐catalyzed
C─H
methylation
of
8‐methylquinolines
is
reported.
The
method
reported
in
this
study,
often
solvent‐free
or
uses
minimal
solvent
(liquid
assisted
grinding),
operates
without
external
heating
under
mild
reaction
conditions,
demonstrating
tolerance
for
various
functional
groups.
Moreover,
the
time
significantly
reduced
compared
to
solvent‐based
variant.
Notably,
can
be
carried
out
using
a
pestle
and
mortar
instead
ball
milling
as
well,
highlighting
operational
simplicity
approach
achieving
challenging
C(sp
3
)‐H
activation
more
sustainable
conditions.
