An Overview of the Recent Advances in Antimicrobial Resistance
Microorganisms,
Год журнала:
2024,
Номер
12(9), С. 1920 - 1920
Опубликована: Сен. 21, 2024
Antimicrobial
resistance
(AMR),
frequently
considered
a
major
global
public
health
threat,
requires
comprehensive
understanding
of
its
emergence,
mechanisms,
advances,
and
implications.
AMR’s
epidemiological
landscape
is
characterized
by
widespread
prevalence
constantly
evolving
patterns,
with
multidrug-resistant
organisms
(MDROs)
creating
new
challenges
every
day.
The
most
common
mechanisms
underlying
AMR
(i.e.,
genetic
mutations,
horizontal
gene
transfer,
selective
pressure)
contribute
to
the
emergence
dissemination
resistant
strains.
Therefore,
mitigation
strategies
(e.g.,
antibiotic
stewardship
programs—ASPs—and
infection
prevention
control
strategies—IPCs)
emphasize
importance
responsible
antimicrobial
use
surveillance.
A
One
Health
approach
interconnectedness
human,
animal,
environmental
health)
highlights
necessity
for
interdisciplinary
collaboration
holistic
in
combating
AMR.
Advancements
novel
therapeutics
alternative
agents
vaccines)
offer
promising
avenues
addressing
challenges.
Policy
interventions
at
international
national
levels
also
promote
ASPs
aiming
regulate
use.
Despite
all
observed
progress,
remains
pressing
concern,
demanding
sustained
efforts
address
emerging
threats
sustainability.
Future
research
must
prioritize
innovative
approaches
complex
socioecological
dynamics
This
manuscript
resource
researchers,
policymakers,
healthcare
professionals
seeking
navigate
develop
effective
mitigation.
Язык: Английский
What is the role of microbial biotechnology and genetic engineering in medicine?
MicrobiologyOpen,
Год журнала:
2024,
Номер
13(2)
Опубликована: Март 31, 2024
Abstract
Microbial
products
are
essential
for
developing
various
therapeutic
agents,
including
antibiotics,
anticancer
drugs,
vaccines,
and
enzymes.
Genetic
engineering
techniques,
functional
genomics,
synthetic
biology
unlock
previously
uncharacterized
natural
products.
This
review
highlights
major
advances
in
microbial
biotechnology,
focusing
on
gene‐based
technologies
medical
applications.
Язык: Английский
Frontiers in superbug management: innovating approaches to combat antimicrobial resistance
Archives of Microbiology,
Год журнала:
2025,
Номер
207(3)
Опубликована: Фев. 14, 2025
Язык: Английский
Illuminating antifungal mode of action and resistance with fluorescent probes
Current Opinion in Chemical Biology,
Год журнала:
2025,
Номер
85, С. 102570 - 102570
Опубликована: Фев. 17, 2025
Язык: Английский
INVASIVE FUNGAL INFECTION CAUSED BY MAGNUSIOMYCES CAPITATUS IN A PEDIATRIC PATIENT WITH BURKITT LYMPHOMA: CASE REPORT AND REVIEW OF LITERATURE
Journal de Mycologie Médicale,
Год журнала:
2025,
Номер
35(2), С. 101547 - 101547
Опубликована: Март 29, 2025
Язык: Английский
Candida albicans: the current status regarding vaginal infections
Applied Microbiology and Biotechnology,
Год журнала:
2025,
Номер
109(1)
Опубликована: Апрель 10, 2025
Abstract
Vaginal
infections
caused
by
Candida
albicans
are
a
significant
global
health
concern
due
to
their
recurrence
and
negative
impact
on
quality
of
life.
This
review
examines
the
pathogenesis
C.
infections,
emphasizing
critical
virulence
factors
such
as
biofilm
formation,
adherence,
phenotypic
switching.
Risk
include
immune
system
suppression,
antibiotic
use,
hormonal
changes,
all
which
can
lead
fungal
overgrowth
infection.
Current
prevention
and/or
treatment
strategies
primarily
rely
antifungal
therapies,
personal
hygiene
practices,
probiotics.
However,
challenges
like
resistance,
recurrence,
limited
efficacy
highlight
need
for
innovative
approaches.
Therefore,
emerging
methods
novel
agents,
vaccines,
nanotechnology-based
delivery
systems
offer
promising
advancements
improve
infection
control.
Additionally,
plays
key
role
in
preventing
with
both
innate
adaptive
immunity
acting
restrict
colonization
growth.
Commercially
available
products,
creams,
vaginal
probiotics,
solutions,
practical
options
but
often
lack
long-term
efficacy.
Persistent
challenges,
including
patient
noncompliance,
restricted
access
hinder
comprehensive
efforts.
Thus,
future
research
should
focus
promoting
interdisciplinary
approaches,
integrating
personalized
medicine,
enhancing
healthcare
accessibility.
intends
present
current
state
art
within
abovementioned
issues
enhance
understanding
multifactorial
nature
advanced
strategies,
essential
reduce
burden
candidiasis
worldwide
life
outcomes.
Key
points
•
involves
biofilms,
Vaccines,
nanotechnology,
new
drugs
improved
treatment.
Addressing
resistance
compliance
is
success.
Graphical
Язык: Английский
Fungal cell wall biogenesis: structural complexity, regulation and inhibition
Fungal Genetics and Biology,
Год журнала:
2025,
Номер
179, С. 103991 - 103991
Опубликована: Май 5, 2025
Язык: Английский
FungAMR: A comprehensive portrait of antimicrobial resistance mutations in fungi
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 7, 2024
Abstract
Antimicrobial
resistance
(AMR)
is
a
global
threat.
To
optimize
the
use
of
our
antifungal
arsenal,
we
need
rapid
detection
and
monitoring
tools
that
rely
on
high-quality
AMR
mutation
data.
Here,
performed
thorough
manual
curation
published
mutations
in
fungal
pathogens
to
produce
FungAMR
reference
dataset.
A
total
462
papers
were
curated,
leading
54,666
entries
all
classified
with
degree
evidence
supports
their
role
resistance.
covers
92
species,
202
genes
184
drugs.
We
combined
variant
effect
predictors
showed
these
could
be
used
help
predict
potential
impact
AMR.
Additionally,
comparative
analysis
among
species
revealed
high
level
convergence
molecular
basis
resistance,
revealing
some
potentially
universal
mutations.
The
also
significant
number
lead
cross-resistance
within
antifungals
class,
as
well
between
classes
for
certain
mutated
genes.
acquisition
clinic
field
an
urging
concern.
Finally,
provide
computational
tool,
ChroQueTas,
leverages
screen
genomes
These
resources
are
anticipated
have
great
utility
researchers
fight
against
Язык: Английский
Structural and Biophysical Dynamics of Fungal Plasma Membrane Proteins and Implications for Echinocandin Action inCandida glabrata
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 30, 2024
Abstract
Fungal
plasma
membrane
proteins
represent
key
therapeutic
targets
for
antifungal
agents,
yet
their
structure
and
spatial
distribution
in
the
native
context
remain
poorly
characterized.
Herein,
we
employ
an
integrative
multimodal
approach
to
elucidate
structural
functional
organization
of
protein
complexes
Candida
glabrata
,
focusing
on
prominent
essential
proteins,
polysaccharide
synthase
β-(1,3)-glucan
(GS)
proton
pump
Pma1.
Cryo-electron
tomography
(cryo-ET)
live
cell
imaging
reveal
that
GS
Pma1
are
heterogeneously
distributed
into
distinct
microdomains.
Treatment
with
caspofungin,
echinocandin
GS,
alters
disrupts
Based
these
findings,
propose
a
model
action
considers
how
drug
interactions
environment
lead
inhibition
GS.
Our
work
underscores
importance
interrogating
dynamic
characteristics
fungal
situ
understand
function
facilitate
precisely
targeted
development
novel
therapies.
Язык: Английский