Angewandte Chemie,
Год журнала:
2024,
Номер
136(37)
Опубликована: Май 22, 2024
Abstract
Though
platinum
(Pt)‐based
complexes
have
been
recently
exploited
as
immunogenic
cell
death
(ICD)
inducers
for
activating
immunotherapy,
the
effective
activation
of
sufficient
immune
responses
with
minimal
side
effects
in
deep‐seated
tumors
remains
a
formidable
challenge.
Herein,
we
propose
first
example
near‐infrared
(NIR)
light‐activated
and
lysosomal
targeted
Pt(II)
metallacycle
(
1
)
supramolecular
ICD
inducer.
synergistically
potentiates
immunomodulatory
response
via
multiple‐regulated
approaches,
involving
NIR
light
excitation,
boosted
reactive
oxygen
species
(ROS)
generation,
good
selectivity
between
normal
tumor
cells,
enhanced
penetration/retention
capabilities.
Specifically,
has
excellent
depth‐activated
ROS
production
(~7
mm),
accompanied
by
strong
anti‐diffusion
anti‐ROS
quenching
ability.
In
vitro
experiments
demonstrate
that
exhibits
significant
cellular
uptake
generation
cells
well
respective
multicellular
spheroids.
Based
on
these
advantages,
induces
more
efficient
an
ultralow
dose
(i.e.,
5
μM)
compared
clinical
inducer‐oxaliplatin
(300
μM).
vivo
,
vaccination
further
serves
potent
inducer
through
eliciting
CD8
+
/CD4
T
Foxp3
depletion
negligible
adverse
effects.
This
study
pioneers
promising
avenue
safe
metal‐based
agents
immunotherapy.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(18)
Опубликована: Фев. 21, 2024
The
development
of
artificial
light-harvesting
systems
mimicking
the
natural
photosynthesis
method
is
an
ever-growing
field
research.
Numerous
such
as
polymers,
metal
complexes,
POFs,
COFs,
supramolecular
frameworks
etc.
have
been
fabricated
to
accomplish
more
efficient
energy
transfer
and
storage.
Among
them,
coordination
complexes
(SCCs)
formed
by
non-covalent
metal-ligand
interaction,
shown
capacity
not
only
undergo
single
multistep
migration
but
also
utilize
harvested
for
a
wide
variety
applications
photocatalysis,
tunable
emissive
systems,
encrypted
anti-counterfeiting
materials,
white
light
emitters
This
review
sheds
on
behavior
both
2D
metallacycles
3D
metallacages
where
design
ingenuity
has
executed
afford
harvesting
donor
ligands
well
acceptors.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 13, 2024
The
combination
of
advanced
photoluminescence
characteristics
to
photochromism
is
highly
attractive
in
preparing
high-performance
multifunctional
photo-responsive
materials
for
optoelectronic
applications.
However,
this
rather
challenging
material
design
owing
the
limited
mechanism
understanding
and
construction
principles.
Here,
an
effective
strategy
integrate
afterglow
emission
carbon
dots
(CDs)
proposed
through
embedding
naphthaleneimide
(NI)
structure
CDs
followed
by
polyvinylpyrrolidone
(PVP)
encapsulation.
NI-structured
CDs-PVP
shows
intrinsic
situ
formation
NI-radical
anions
controllable
multi-stimuli-responsive
behaviors
related
oxygen-trigged
triplet
exciton
quenching
Förster
resonance
energy
transfer
(FRET)
from
pristine
photoactivated
radicals.
Notably,
a
wide
range
appearance
colors
colorless
brown,
luminescence
color
transition
blue
yellow,
much
elongated
lifetime
up
253
ms
are
observed.
With
extraordinary
stimuli-chromic
stimuli-luminescent
film
dynamically
responsive
multiple
external
stimuli,
reversible
secure
snapchat,
data
encryption/decryption
synaptic
imaging
recognition
realized.
These
findings
demonstrate
fundamental
principle
photochromic
with
afterglow,
providing
important
understandings
on
synergic
dynamic
thereby
expanding
their
applications
information
anti-counterfeiting
artificial
intelligence.
Advanced Materials Technologies,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Abstract
Stimuli‐responsive
materials
with
optical
adaptibility
to
external
triggers
are
versatile
for
diverse
applications.
Among
these,
smart
chromic
molecular
photoswitching
enable
real‐time
absorption
changes
indications,
crucial
sensing,
security,
sensors,
authentication,
and
anti‐counterfeiting
This
current
study
presents
an
intriguing
approach
develop
spiropyran
(SP)‐based
switches
rapid
reversible
photochromism.
Three
dual‐responsive
functional
SPs
(f‐SPs)
dyes
varying
SP
moieties
(1–3)
synthesized
using
straightforward
chemical
method.
The
responsiveness
of
f‐SPs
dual
stimuli,
such
as
organic
solvents
polarity
light
sources
different
wavelengths
(365
530
nm),
is
investigated.
increasing
(non‐polar
polar)
facilitated
stabilization
merocyanine
(MC)
isomer.
On
contrary,
upon
irradiation
sources,
exhibited
significant,
real‐time,
highly
in
color.
photochromic
reversibility
within
20
s
increased
moieties.
Furthermore,
incorporated
into
Polydimethylsiloxane
(PDMS)
polymer
matrix.
resulting
composite
films
displayed
exceptional
photostability,
responses,
reduced
photo
fatigue.
Additionally,
versatility
sensing
demonstrated
by
tailoring
structural
isomerization
these
photo‐patterning
work
paves
way
advanced
cutting‐edge
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(37)
Опубликована: Май 22, 2024
Though
platinum
(Pt)-based
complexes
have
been
recently
exploited
as
immunogenic
cell
death
(ICD)
inducers
for
activating
immunotherapy,
the
effective
activation
of
sufficient
immune
responses
with
minimal
side
effects
in
deep-seated
tumors
remains
a
formidable
challenge.
Herein,
we
propose
first
example
near-infrared
(NIR)
light-activated
and
lysosomal
targeted
Pt(II)
metallacycle
(1)
supramolecular
ICD
inducer.
1
synergistically
potentiates
immunomodulatory
response
via
multiple-regulated
approaches,
involving
NIR
light
excitation,
boosted
reactive
oxygen
species
(ROS)
generation,
good
selectivity
between
normal
tumor
cells,
enhanced
penetration/retention
capabilities.
Specifically,
has
excellent
depth-activated
ROS
production
(~7
mm),
accompanied
by
strong
anti-diffusion
anti-ROS
quenching
ability.
In
vitro
experiments
demonstrate
that
exhibits
significant
cellular
uptake
generation
cells
well
respective
multicellular
spheroids.
Based
on
these
advantages,
induces
more
efficient
an
ultralow
dose
(i.e.,
5
μM)
compared
clinical
inducer-oxaliplatin
(300
μM).
vivo,
vaccination
further
serves
potent
inducer
through
eliciting
CD8
Abstract
Harnessing
nanoscale
molecular
structural
changes
to
achieve
precise
control
over
macroscopic
devices
represents
an
emerging
and
effective
strategy.
One
promising
approach
involves
the
introduction
of
light‐driven
chiral
dopants
into
liquid
crystals
(LCs),
enabling
fine‐tuned
modulation
helical
superstructures
in
cholesteric
(CLCs)
via
photoisomerization.
This
strategy
opens
up
exciting
possibilities
for
development
innovative
photo‐responsive
with
dynamic
functionalities.
review
focuses
on
most
common
used
LCs,
including
azobenzene,
diarylethene,
α
‐cyanostilbene
overcrowded
alkene.
The
chemical
design
principles
these
four
types
switches
are
highlighted,
along
their
abilities
induce
pitch
inversion
CLCs.
Finally,
applications
controlling
showcased,
particularly
display
technologies,
anti‐counterfeiting,
optical
3D
droplet
manipulation.
It
is
hoped
that
this
provides
valuable
insights
guidances
novel
advancement
soft
matter
material
applications.
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
Ethylenediamine
(EDA),
as
an
important
chemical
raw
material
and
fine
intermediate,
has
been
widely
applied
in
various
industries.
Real-time
monitoring
of
EDA
is
highly
desirable
daily
life
due
to
its
potential
threat
human
health.
Herein,
we
report
a
molecular
probe
named
4,4'-(9H-carbazole-3,6-diyl)bis(1-(naphthalen-2-ylmethyl)pyridin-1-ium)
iodide
(p-N-DPC·I2)
with
ratiometric
luminescent
colorimetric
dual-mode
responses
toward
EDA,
endowing
sensitive
selective
detection
method
for
real-time
monitoring.
The
experimental
theoretical
calculation
results
revealed
that
the
response
mechanism
was
forming
charge
transfer
(CT)
state
when
p-N-DPC·I2
met
EDA.
In
addition,
hydrogel-based
sensing
chip
developed
achieve
ultrasensitive
recognition
vapor
naked
eye
at
concentration
low
10
ppm.
This
study
new
fluorescent
modes
detect
both
solution
vapor.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Abstract
Organic
room
temperature
phosphorescence
(ORTP)
polymer
materials
have
sparked
considerable
research
interests
in
recent
years,
but
their
optical
function
is
still
limited
for
multi‐mode
imaging.
Herein,
a
feasible
and
universal
approach
proposed
to
endow
ORTP
with
periodic
refractive
index
modulation
functions
by
holographic
patterning.
The
key
this
design
two‐stage
stepwise
crosslinking.
Stage‐1,
low
crosslinking
density
(≤0.75
mol
L
−1
),
phosphorescence‐silent
can
provide
greater
free
volume
monomer
diffusion
thus
facilitate
the
patterning
of
modulated
holograms
via
photopolymerization‐induced
phase
separation.
dense
at
stage‐2
turn
on
intensity
rising
144%
when
increases
from
3.77
4.12
.
enhanced
primarily
ascribed
increase
conformational
distortion
spin‐orbit
coupling
organic
phosphors
based
theoretical
calculations.
Eventually,
first
example
demonstrated
plastic
unique
capability
independently
displaying
andphosphorescent
images.
This
work
not
only
provides
novel
paradigm
impart
added
also
paves
way
development
high‐security
combat
counterfeiting.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(36), С. 24901 - 24910
Опубликована: Авг. 28, 2024
The
effect
of
host–guest
interactions
on
the
chemistry
encapsulated
molecules
is
a
fascinating
field
research
that
has
gained
momentum
in
recent
years.
Much
work
this
been
focused
such
catalysis
and
photoluminescence
dyes.
However,
related
photoinduced
processes,
as
photoregulated
oxidase-mimicking
activity,
not
explored
much.
Herein,
we
report
unique
example
enhancement
oxidase-like
activity
benzothiadiazole
dye
(G1)
water
through
encapsulation
within
M8L4
molecular
barrel
(1).
Favorable
helped
guest
G1
to
have
better
electron
transfer
oxygen
leading
increased
production
superoxide
radical
anions
activity.
Furthermore,
inside
1
also
caused
change
redox
potentials
which
after
produced
oxidizing
agent
than
free
G1.
These
phenomena
combined
enhance
upon
cage
1.
present
demonstrates
processes.
