Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 18, 2024
Abstract
Ventricular
arrhythmias
(VAs)
triggered
by
myocardial
infarction
(MI)
are
the
leading
cause
of
sudden
cardiac
mortality
worldwide.
Current
therapeutic
strategies
for
managing
MI‐induced
VAs,
such
as
left
stellate
ganglion
resection
and
ablation,
suboptimal,
highlighting
need
to
explore
safer
more
effective
intervention
strategies.
Herein,
we
rationally
designed
two
supramolecular
sonosensitizers
RuA
RuB
,
engineered
through
acceptor
modification
generate
moderate
reactive
oxygen
species
(ROS)
modulate
VAs.
Both
demonstrated
high
ultrasound
(US)‐activated
ROS
production
efficiency,
with
singlet
(
1
O
2
)
quantum
yield
(Φ
Δ
0.70
0.88,
respectively,
surpassing
ligand
IR1105
conventional
sonosensitizer
ICG
=0.40).
In
vitro,
at
a
modest
concentration
under
US
intensity
notably
boosts
pro‐survival
autophagy
in
microglia
BV2
cell.
To
improve
vivo
stability
biocompatibility,
was
further
encapsulated
into
DSPE‐PEG
5000
prepare
nanoparticles
NPs).
studies
after
microinjection
NPs
paraventricular
nucleus
(PVN)
subsequent
exposure,
that
NPs‐mediated
modulation
effectively
suppresses
sympathetic
nervous
activity
(SNA)
inflammatory
responses,
thereby
preventing
Importantly,
no
tissue
injury
observed
post
modulation.
This
work
pioneers
design
long‐wave
emission
sonosensitizers,
offering
new
insights
regulating
cardiovascular
diseases.
Chemical Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Immunogenic
cell
death
(ICD)
has
attracted
enormous
attention
over
the
past
decade
due
to
its
unique
characteristics
in
cancer
and
role
activating
innate
adaptive
immune
responses
against
tumours.
Many
efforts
have
been
dedicated
screening,
identifying
discovering
ICD
inducers,
resulting
validation
of
several
based
on
metal
complexes.
In
this
review,
we
provide
a
comprehensive
summary
current
metal-based
their
molecular
mechanisms
for
triggering
initiation
subsequent
protective
antitumour
responses,
along
with
considerations
validating
both
vitro
vivo.
We
also
aim
offer
insights
into
future
development
complexes
enhanced
ICD-inducing
properties
applications
potentiating
immunity.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(27), С. 34591 - 34606
Опубликована: Июнь 25, 2024
Immunotherapy
has
emerged
as
a
revolutionizing
therapeutic
modality
for
cancer.
However,
its
efficacy
been
largely
limited
by
weak
immune
response
and
an
immunosuppressive
tumor
microenvironment.
Herein,
we
report
metal–organic
framework
(MOF)-derived
titanium
oxide
nanoparticle
(MCTx
NP)
booster
that
can
greatly
improve
the
immunotherapy
inducing
"immunogenic
cell
death"
(ICD)
remodeling
The
NPs,
inheriting
characteristic
structure
of
MIL-125
enriched
with
oxygen
vacancies
(OVs),
demonstrate
both
high
photothermal
conversion
efficiency
reactive
species
(ROS)
generation
yield
upon
near-infrared
(NIR)
activation.
Moreover,
NPs
release
O2
reduce
glutathione
(GSH)
in
environment,
showcasing
their
potential
to
reverse
In
vitro/vivo
results
MCTx
directly
kill
cells
effectively
eliminate
primary
tumors
exerting
dual
photodynamic/photothermal
therapy
under
single
NIR
irritation.
At
same
time,
augment
PD-L1
blockade
potently
ICDs
reversing
microenvironment,
including
promoting
dendritic
(DC)
maturation,
decreasing
regulatory
T
(Tregs)'
infiltration,
increasing
cytotoxic
lymphocytes
(CTLs)
helper
(Ths),
resulting
effective
distant
suppression.
This
work
highlights
NP-mediated
photodynamic-
photothermal-enhanced
strategy
treatment.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 22, 2024
Pyroptosis,
a
lytic
form
of
cell
death
mediated
by
the
gasdermin
family,
is
characterized
swelling
and
membrane
rupture.
Inducing
pyroptosis
in
cancer
cells
can
enhance
antitumor
immune
responses
promising
strategy
for
therapy.
However,
excessive
may
trigger
development
inflammatory
diseases
due
to
immoderate
continuous
reactions.
Nanomaterials
nanobiotechnology,
renowned
their
unique
advantages
diverse
structures,
have
garnered
increasing
attention
owing
potential
induce
such
as
cancer.
A
nano-delivery
system
drug-induced
overcome
limitations
small
molecules.
Furthermore,
nanomedicines
directly
manipulate
pyroptosis.
This
review
summarizes
discusses
latest
advancements
nanoparticle-based
treatments
with
among
cancer,
focusing
on
functions
mechanisms
providing
valuable
insights
into
selecting
nanodrugs
clinical
application
these
strategies
still
faces
challenges
limited
understanding
nanobiological
interactions.
Finally,
future
perspectives
emerging
field
pyroptotic
nanomaterials
are
presented.
Specifically
improving
the
intratumoral
accumulation
and
retention
achieving
maximum
therapeutic
efficacy
of
small-molecule
chemotherapeutics
remains
a
considerable
challenge.
To
address
issue,
we
here
reported
near-infrared
(NIR)
irradiation-activatable
targeted
covalent
nanodrugs
by
installing
diazirine-labeled
transferrin
receptor
1
(TfR1)-targeted
aptamers
on
PEGylated
phospholipid-coated
upconversion
nanoparticles
followed
doxorubicin
loading.
Targeted
recognized
then
were
activated
to
covalently
cross-link
with
TfR1
cancer
cells
980
nm
NIR
irradiation.
Systematic
studies
revealed
that
they
achieved
>6-
>5.5-fold
higher
accumulations
than
aptamer-based
at
6
120
h
post
intravenous
injection,
respectively.
Based
high
drug
delivery
efficacy,
boosted
doxorubicin-induced
immunogenic
cell
death,
antitumor
immune
responses
shrank
sizes
both
primary
distant
tumors,
displayed
better
less
adverse
effect
commercial
Doxil
in
4T1
syngeneic
breast
tumor
model
featuring
an
immunosuppressive
microenvironment.
By
integrating
specificity
molecular
recognition,
reactivity
profile
diazirine
accuracy
light
manipulation
nanodrug
supremacy,
our
could
be
expected
as
longer-term
efficient
strategy
improve
anticancer
chemotherapeutics.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 18, 2024
Ventricular
arrhythmias
(VAs)
triggered
by
myocardial
infarction
(MI)
are
the
leading
cause
of
sudden
cardiac
mortality
worldwide.
Current
therapeutic
strategies
for
managing
MI-induced
VAs,
such
as
left
stellate
ganglion
resection
and
ablation,
suboptimal,
highlighting
need
to
explore
safer
more
effective
intervention
strategies.
Herein,
we
rationally
designed
two
supramolecular
sonosensitizers
RuA
RuB,
engineered
through
acceptor
modification
generate
moderate
reactive
oxygen
species
(ROS)
modulate
VAs.
Both
RuB
demonstrated
high
ultrasound
(US)-activated
ROS
production
efficiency,
with
singlet
(
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 19, 2024
Sonodynamic
therapy
(SDT)
can
generate
reactive
oxygen
species
(ROS)
to
combat
multidrug-resistant
biofilms,
which
pose
significant
challenges
human
health.
As
the
key
producing
ROS
in
SDT,
design
of
sonosensitizers
with
optimal
molecular
structures
for
sufficient
generation
and
activity
complex
biofilm
matrix
is
essential.
In
this
study,
we
propose
a
π-expansion
strategy
synthesize
series
small-molecule
metal
Ru(II)
complexes
(
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 15, 2024
Abstract
The
assembly
of
low‐immunogenic
poly(ethylene
glycol)
nanoparticles
(PEG
NPs)
for
targeted
delivery
therapeutics
(i.e.,
mitoxantrone
and
imidazoquinoline)
improved
photothermal‐immunotherapy
is
reported.
PEG
NPs
incorporating
targeting
molecules
hyaluronic
acid
are
engineered
via
the
templating
metal–organic
frameworks,
which
can
circumvent
accelerated
blood
clearance
exhibit
prolonged
circulation
time
as
well
accumulation
at
tumor
sites.
under
laser
radiation
induces
immunogenic
cell
death
cells,
combined
with
toll‐like
receptor
7/8
agonists
imidazoquinoline
to
trigger
immune
responses
cytotoxic
T
lymphocytes
eradication
cells.
Furthermore,
treatment
induce
tumor‐specific
that
inhibit
metastatic
lung
growth.
This
reported
provide
a
rational
design
cancer
immunotherapy.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 15, 2024
Cancer
immunotherapy
holds
significant
promise
for
improving
cancer
treatment
efficacy;
however,
the
low
response
rate
remains
a
considerable
challenge.
To
overcome
this
limitation,
advanced
catalytic
materials
offer
potential
in
augmenting
by
modulating
immunosuppressive
tumor
microenvironment
(TME)
through
precise
biochemical
reactions.
Achieving
optimal
targeting
precision
and
therapeutic
efficacy
necessitates
thorough
understanding
of
properties
underlying
mechanisms
tumor-targeted
materials.
This
review
provides
comprehensive
systematic
overview
recent
advancements
their
critical
role
enhancing
immunotherapy.
It
highlights
types
reactions,
construction
strategies
materials,
fundamental
targeting,
including
passive,
bioactive,
stimuli-responsive,
biomimetic
approaches.
Furthermore,
outlines
various
tumor-specific
strategies,
encompassing
tissue,
cell,
exogenous
TME-responsive,
cellular
TME
strategies.
Finally,
discussion
addresses
challenges
future
perspectives
transitioning
into
clinical
applications,
offering
insights
that
pave
way
next-generation
therapies
provide
substantial
benefits
to
patients
settings.
Targets,
Год журнала:
2024,
Номер
2(4), С. 327 - 340
Опубликована: Окт. 31, 2024
Afterglow
imaging
plays
a
crucial
role
in
the
cancer
treatment
field.
In
contrast
to
inorganic
afterglow
agents,
organic
agents
possess
easily
modifiable
structures
and
exhibit
excellent
biocompatibility,
thereby
presenting
significant
prospects
for
application
tumor
diagnosis
management.
this
review,
we
summarize
design
principles
applications
of
probes
therapy.
Finally,
discuss
future
challenges
