Stereo-selective synthesis of complex dienes and eneynes by sequential hydroarylation and olefinic C–H functionalization DOI

Yuhang Zhu,

Xiaoli Li,

Cheng Zhang

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(16), С. 4456 - 4463

Опубликована: Янв. 1, 2024

We present a preparation of complex dienes and eneynes by Rh-catalyzed hydroarylation internal alkynes Pd-catalyzed olefinic C–H alkenylation, alkynylation allylation, enabled the chelation assistance pyrazinamide or picolinamide.

Язык: Английский

Synthesis of 12- to 26-Membered Macrocyclic Dienes by Directed Intramolecular Alkene/Alkyne Cross-Coupling DOI

Xiandie Zhang,

Xiuying Liu, Xiaoli Li

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

The first iridium-catalyzed intramolecular alkene/alkyne cross-coupling reaction has been developed to prepare a wide range of 12- 26-membered macrocyclic 1,3-dienes. This operationally simple protocol proceeded by NHTs amide-enabled alkenyl C-H functionalization and exhibited functionality tolerance excellent E/Z ratio selectivity.

Язык: Английский

Процитировано

0
N,N- and N,O-Bidentate-Chelation-Assisted Alkenyl C–H Functionalization DOI Creative Commons

Yawei Zhang,

Chengxing Peng,

Xiaoli Li

и другие.

Molecules, Год журнала: 2025, Номер 30(8), С. 1669 - 1669

Опубликована: Апрель 8, 2025

Chelation-assisted olefinic C-H functionalization has been demonstrated to be a powerful method of constructing multi-substituted alkenes from simpler ones. This strategy produces complex in regio- and stereoselective manner, followed by endo- exo-cyclometallation. Among the various directing groups developed, N,N- N,O-bidentate are most widely used selectively promote due their fine, tunable, reversible coordination with metal center. In this review, we discuss group-assisted bond reactions, including alkenylation, alkylation, arylation, thiolation, silylation, halogenation, cyclization.

Язык: Английский

Процитировано

0
Chelation-assisted α and β C–H functionalization of aryl alkenes with alkynes and alkenes DOI
Cheng Zhang, Lin Yu,

Yuhang Zhu

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(17), С. 4862 - 4868

Опубликована: Янв. 1, 2024

α C–H alkenylation of aryl alkenes by six-membered exo -palladacycles was demonstrated to afford dienes, which underwent β through seven-membered endo produce trienes with excellent E / Z ratio selectivity.

Язык: Английский

Процитировано

2
Stereo-selective synthesis of complex dienes and eneynes by sequential hydroarylation and olefinic C–H functionalization DOI

Yuhang Zhu,

Xiaoli Li,

Cheng Zhang

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(16), С. 4456 - 4463

Опубликована: Янв. 1, 2024

We present a preparation of complex dienes and eneynes by Rh-catalyzed hydroarylation internal alkynes Pd-catalyzed olefinic C–H alkenylation, alkynylation allylation, enabled the chelation assistance pyrazinamide or picolinamide.

Язык: Английский

Процитировано

1