Neural Regeneration Research,
Год журнала:
2024,
Номер
20(12), С. 3501 - 3516
Опубликована: Дек. 16, 2024
Vision
restoration
presents
a
considerable
challenge
in
the
realm
of
regenerative
medicine,
while
recent
progress
ultrasound
stimulation
has
displayed
potential
as
non-invasive
therapeutic
approach.
This
narrative
review
offers
comprehensive
overview
current
research
on
ultrasound-stimulated
neuromodulation,
emphasizing
its
treatment
modality
for
various
nerve
injuries.
By
examining
efficacy
different
types
modulating
peripheral
and
optic
nerves,
we
can
delve
into
their
underlying
molecular
mechanisms.
Furthermore,
underscores
sonogenetics
vision
restoration,
which
involves
leveraging
pharmacological
genetic
manipulations
to
inhibit
or
enhance
expression
related
mechanosensitive
channels,
thereby
strength
response.
We
also
address
how
methods
such
viral
transcription
be
utilized
render
specific
neurons
organs
highly
responsive
ultrasound,
leading
significantly
improved
outcomes.
Trends in biotechnology,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 1, 2024
In
recent
decades,
the
field
of
synthetic
biology
has
witnessed
remarkable
progress,
driving
advances
in
both
research
and
practical
applications.
One
pivotal
area
development
involves
design
transgene
switches
capable
precisely
regulating
specified
outputs
controlling
cell
behaviors
response
to
physical
cues,
which
encompass
light,
magnetic
fields,
temperature,
mechanical
forces,
ultrasound,
electricity.
this
review,
we
delve
into
cutting-edge
progress
made
physically
controlled
protein
expression
engineered
mammalian
cells,
exploring
diverse
genetic
tools
strategies
available
for
engineering
targeting
cells
sense
these
cues
generate
desired
accordingly.
We
discuss
precision
efficiency
limitations
inherent
tools,
while
also
highlighting
their
immense
potential
therapeutic
Communications Biology,
Год журнала:
2025,
Номер
8(1)
Опубликована: Март 6, 2025
The
present
challenge
in
neuroscience
is
to
non-invasively
exercise
low-power
and
high-fidelity
control
of
neurons
situated
deep
inside
the
brain.
Although,
two-photon
optogenetic
excitation
can
activate
millimeter
depth
with
sub-cellular
specificity
millisecond
temporal
resolution,
it
also
cause
heating
targeted
tissue.
On
other
hand,
sonogenetics
modulate
cellular
activity
expressed
mechano-sensitive
proteins
deeper
areas
brain
less
spatial
selectivity.
We
a
theoretical
analysis
synergistic
sono-optogenetic
method
overcome
these
limitations
by
co-expressing
(MscL-I92L)
ion-channel
light-sensitive
(CoChR/ChroME2s/ChRmine)
hippocampal
neurons.
It
shown
that
presence
low-amplitude
subthreshold
ultrasound
pulses,
threshold
for
neural
spiking
reduces
drastically
73%
MscL-I92L-CoChR
(0.021
mW/µm2),
66%
MscL-I92L-ChroME2s
(0.029
64%
MscL-I92L-ChRmine
(0.013
mW/µm2)
at
5
Hz.
allows
up
1.2
cm
combination.
useful
design
new
experiments
multimodal
neuroprosthetic
devices
circuits.
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(17), С. 2066 - 2070
Опубликована: Апрель 29, 2024
Abstract
Polymer
mechanochemistry
has
rapidly
evolved
since
the
mid‐2000s.
Recent
advancements
highlight
development
of
mechanophore
platforms
for
controlled
release
bioactive
payloads
and
exploration
biocompatible
activation
strategies.
These
platforms,
ranging
from
furan‐maleimide
Diels‐Alder
adducts
to
disulfide
motifs
with
β
‐carbonate
linkages,
demonstrate
promising
prospects
in
targeted
drug
delivery.
Additionally,
supramolecular
assemblies
free
radical‐generating
mechanophores
present
innovative
avenues
potential
therapeutic
applications.
Biocompatible
methods,
notably
high‐intensity
and/or
low‐intensity
focused
ultrasound,
hold
vivo
However,
challenges
persist
comprehending
fundamental
physics
ultrasound
its
utilization
activation.
Future
directions
emphasize
importance
simplicity
polymer
designs,
stability
under
physiological
conditions,
precise
control
mechanical
enhanced
biomedical
clinical
utility.
Despite
aforementioned
chemical
technical
obstacles,
outlook
applications
remains
promising,
urging
continued
advancement.
Key
Scientists
Advanced Materials,
Год журнала:
2024,
Номер
36(32)
Опубликована: Май 28, 2024
Polymer
mechanochemistry
utilizes
mechanical
force
to
activate
latent
functionalities
in
macromolecules
and
widely
relies
on
ultrasonication
techniques.
Fundamental
constraints
of
frequency
power
intensity
have
prohibited
the
application
polymer
principles
a
biomedical
context
up
now,
although
medical
ultrasound
is
clinically
established
modality.
Here,
universal
polynucleotide
framework
presented
that
allows
binding
release
therapeutic
oligonucleotides,
both
DNA-
RNA-based,
as
cargo
by
biocompatible
imaging
ultrasound.
It
shown
high
molar
mass,
colloidal
assembly,
distinct
mechanochemical
mechanism
enable
force-induced
subsequent
activation
biological
function
vitro
vivo.
Thereby,
this
work
introduces
platform
for
exploration
questions
therapeutics
development
steered
force.
Chemical Society Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Hydrogels
are
emerging
as
promising
candidates
for
brain–computer
interfaces.
This
review
highlights
the
current
advancements
in
implantable
hydrogel
electrodes
neural
signal
recording,
neuromodulation,
and
brain
disorder
treatment.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 3, 2024
Abstract
Sonogenetics
is
an
innovative
technology
that
integrates
ultrasound
with
genetic
editing
to
precisely
modulate
cellular
activities
in
a
non‐invasive
manner.
This
method
entails
introducing
and
activating
mechanosensitive
channels
on
the
cell
membrane
of
specific
cells
using
gene
delivery
vectors.
When
exposed
ultrasound,
these
can
be
manipulated
open
or
close,
thereby
impacting
functions.
currently
being
used
extensively
treatment
various
chronic
diseases,
including
Parkinson's
disease,
vision
restoration,
cancer
therapy.
paper
provides
comprehensive
review
key
components
sonogenetics
focuses
evaluating
its
prospects
potential
challenges
disease.
Applied Optics,
Год журнала:
2024,
Номер
63(24), С. 6306 - 6306
Опубликована: Авг. 12, 2024
The
interesting
interaction
between
the
laser
and
ultrasound
field
in
a
liquid
medium
has
been
an
issue
optical
physics
research,
attracting
large
number
of
experimental
theoretical
studies.
To
facilitate
real-time
detection
dynamic
ultrasonic
signals
within
environments,
experiments
involving
heterodyne
self-mixing
interferometry
were
employed.
In
order
to
achieve
purpose
we
designed
birefringent-Zeeman
dual-frequency
for
experiments.
Through
simulation
studies,
elucidated
physical
mechanism
propagating
media
their
modulatory
impact
on
systems.
Meanwhile,
signal
frequency
measured
via
approach
exhibits
average
error
0.87%,
intensity
−14.55dBm,
sensitivity
is
28.9
dB
higher
than
interferometry.
These
high-precision,
high-resolution
methodologies
promise
rectify
shortcomings
inherent
traditional
techniques
concerning
calibration.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 18, 2024
Utilizing
ultrasound
as
an
external
stimulus
to
remotely
modulate
the
activity
of
proteins
is
important
aspect
sonopharmacology
and
establishes
basis
for
emerging
field
sonogenetics.
Here,
we
describe
ultrasound-responsive
protein
splicing
system
that
enables
spatiotemporal
control
split-intein-mediated
ligation.
The
utilizes
engineered
split
inteins
are
caged
can
be
activated
by
thrombin
released
from
a
high
molar
mass
DNA-based
carrier
under
focused
sonication.
This
approach
represents
general
method
controlling
functions
interest
ultrasound,
demonstrated
here
controlled
synthesis
superfolder
green
fluorescence
(GFP)
calcitonin.
Furthermore,
calcitonin
receptor-mediated
signal
transduction
in
cells
was
triggered
this
vitro
without
harming
cell
viability.
By
expanding
sonogenetic
toolbox
with
technologies,
study
provides
possible
pathway
deploy
variety
deep
tissue
future.
