Recent developments in the enzymatic modifications of steroid scaffolds

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(18), С. 3559 - 3583

Опубликована: Янв. 1, 2024

This review highlights the recent advancements in enzymatic modifications of steroid scaffolds, emphasizing hydroxylation, ketoreduction, dehydrogenation, cascade reactions, and other modifications.

Язык: Английский

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Modular Chemoenzymatic Cascade for Highly Diastereo- and Enantioselective Synthesis of 1,3-Disubstituted Tetrahydroisoquinolines

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 5426 - 5434

Опубликована: Март 18, 2025

Язык: Английский

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Concise and Modular Chemoenzymatic Total Synthesis of Bisbenzylisoquinoline Alkaloids

Angewandte Chemie, Год журнала: 2024, Номер unknown

Опубликована: Сен. 21, 2024

Abstract The bisbenzylisoquinoline alkaloids (bisBIAs) have attracted tremendous attention from the synthetic community due to their diverse and intriguing biological activities. Herein, we report convergent modular chemoenzymatic syntheses of eight bisBIAs bearing various substitutes linkages in 5–7 steps. gram‐scale synthesis well‐designed enantiopure benzylisoquinoline monomers was accomplished through an enzymatic stereoselective Pictet–Spengler reaction, followed by regioselective methylation or chemical functionalization a sequential one‐pot process. A modified intermolecular copper‐mediated Ullmann coupling enabled concise efficient total five different linear with either head‐to‐tail tail‐to‐tail linkage. biomimetic oxidative phenol dimerization selectively formed sterically hindered, electron‐rich diaryl ether bond, subsequent intramolecular Suzuki–Miyaura domino reaction facilitated first enantioselective three macrocyclic bisBIAs, including ent ‐isogranjine, tetrandrine O ‐methylrepandine. This study highlights great potential strategies paves way further explore functions these natural products.

Язык: Английский

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Intriguing steroid glycosides for cancer therapy by suppressing the DNA damage response and mTOR/S6K signaling pathways

Bioorganic Chemistry, Год журнала: 2024, Номер 151, С. 107619 - 107619

Опубликована: Июль 9, 2024

Язык: Английский

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Notizen aus der Chemie

Nachrichten aus der Chemie, Год журнала: 2024, Номер 72(5), С. 48 - 51

Опубликована: Апрель 30, 2024

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