Notizen aus der Chemie DOI

Lena Barra,

Guillaume Delaittre, Georg Dierkes

et al.

Nachrichten aus der Chemie, Journal Year: 2024, Volume and Issue: 72(5), P. 48 - 51

Published: April 30, 2024

Recent developments in the enzymatic modifications of steroid scaffolds DOI Creative Commons
Huibin Wang, Ikuro Abe

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(18), P. 3559 - 3583

Published: Jan. 1, 2024

This review highlights the recent advancements in enzymatic modifications of steroid scaffolds, emphasizing hydroxylation, ketoreduction, dehydrogenation, cascade reactions, and other modifications.

Language: Английский

Citations

6
Modular Chemoenzymatic Cascade for Highly Diastereo- and Enantioselective Synthesis of 1,3-Disubstituted Tetrahydroisoquinolines DOI
Honghui Zhang, Yan Zhang,

Changtong Zhu

et al.

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 5426 - 5434

Published: March 18, 2025

Language: Английский

Citations

0
Concise and Modular Chemoenzymatic Total Synthesis of Bisbenzylisoquinoline Alkaloids DOI
Xiaoguang Lei, Jin Wang, Jianxiong Zhao

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 21, 2024

Abstract The bisbenzylisoquinoline alkaloids (bisBIAs) have attracted tremendous attention from the synthetic community due to their diverse and intriguing biological activities. Herein, we report convergent modular chemoenzymatic syntheses of eight bisBIAs bearing various substitutes linkages in 5–7 steps. gram‐scale synthesis well‐designed enantiopure benzylisoquinoline monomers was accomplished through an enzymatic stereoselective Pictet–Spengler reaction, followed by regioselective methylation or chemical functionalization a sequential one‐pot process. A modified intermolecular copper‐mediated Ullmann coupling enabled concise efficient total five different linear with either head‐to‐tail tail‐to‐tail linkage. biomimetic oxidative phenol dimerization selectively formed sterically hindered, electron‐rich diaryl ether bond, subsequent intramolecular Suzuki–Miyaura domino reaction facilitated first enantioselective three macrocyclic bisBIAs, including ent ‐isogranjine, tetrandrine O ‐methylrepandine. This study highlights great potential strategies paves way further explore functions these natural products.

Language: Английский

Citations

2
Intriguing steroid glycosides for cancer therapy by suppressing the DNA damage response and mTOR/S6K signaling pathways DOI

Pei-Pei An,

Hui Huang,

Su-Jie Ru

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 151, P. 107619 - 107619

Published: July 9, 2024

Language: Английский

Citations

1
Notizen aus der Chemie DOI

Lena Barra,

Guillaume Delaittre, Georg Dierkes

et al.

Nachrichten aus der Chemie, Journal Year: 2024, Volume and Issue: 72(5), P. 48 - 51

Published: April 30, 2024

Citations

0