Palladium-Catalyzed C(O)–C Bond Cleavage of Unstrained Ketones Assisted with Aryl Handles: An Approach to Diaryl Ketones

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

C-C bond cleavage reactions have achieved remarkable progress in molecular deconstruction and skeleton editing. In this study, we describe a palladium-catalyzed synthesis of diaryl ketones through sequence α-arylation aerobic oxidative cleavage. This transformation features good functional group compatibility, especially for highly reactive groups, including -OH, NH2, -CHO. Furthermore, approach allows gram-scale low catalyst loading manner. It also streamlines the variety drugs or their intermediates. Mechanism studies reveal essential role utilizing bulky ligand existence air as reaction atmosphere.

Язык: Английский

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Aromatic Deformylative Deuteration Enabled by Cobalt–Photocatalysis at Ambient Temperature

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 8522 - 8529

Опубликована: Май 6, 2025

Язык: Английский

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Photocatalytic Hydrogenation of Alkenes Using Water as Both the Reductant and the Proton Source

Advanced Science, Год журнала: 2024, Номер 11(44)

Опубликована: Окт. 9, 2024

Abstract Utilization of clean and low‐cost water as the reductant to enable hydrogenation alkenes is highly attractive in green chemistry. However, this research subject considerably challenging due sluggish kinetics oxidation half‐reaction. It also very difficult avoid undesired because that far easier occur than desired from thermodynamic standpoint. Herein, challenge overcome by applying a cooperative catalysis where HCl used cocatalyst accelerate Pt/g‐C 3 N 4 ‐catalyzed suppress alkene. This provides an example for using proton source photocatalytic alkenes. The present method exhibits broad substrate applicability, allows various arylethenes aliphatic undergo smoothly.

Язык: Английский

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Ring Expansion of 3-Hydroxyoxindoles to 4-Quinolones via Palladium-Catalyzed C–C(acyl) Bond Cleavage and Subsequent Camps Cyclization

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

We report herein the construction of 4-quinolones via palladium-catalyzed regioselective β-acyl elimination 3- hydroxyoxindoles and a subsequent Camps cyclization process.

Язык: Английский

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