Ring Expansion of 3-Hydroxyoxindoles to 4-Quinolones via Palladium-Catalyzed C–C(acyl) Bond Cleavage and Subsequent Camps Cyclization DOI

Zhi-Cong Huang,

Z.J. Ruan,

Hui Xu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

We report herein the construction of 4-quinolones via palladium-catalyzed regioselective β-acyl elimination 3- hydroxyoxindoles and a subsequent Camps cyclization process.

Language: Английский

Palladium-Catalyzed C(O)–C Bond Cleavage of Unstrained Ketones Assisted with Aryl Handles: An Approach to Diaryl Ketones DOI
Qiang Li, Yang Long,

Qinyue Tao

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

C-C bond cleavage reactions have achieved remarkable progress in molecular deconstruction and skeleton editing. In this study, we describe a palladium-catalyzed synthesis of diaryl ketones through sequence α-arylation aerobic oxidative cleavage. This transformation features good functional group compatibility, especially for highly reactive groups, including -OH, NH2, -CHO. Furthermore, approach allows gram-scale low catalyst loading manner. It also streamlines the variety drugs or their intermediates. Mechanism studies reveal essential role utilizing bulky ligand existence air as reaction atmosphere.

Language: Английский

Citations

0
Aromatic Deformylative Deuteration Enabled by Cobalt–Photocatalysis at Ambient Temperature DOI

Dongcheng Zheng,

Ye Wang, Tiantian Liang

et al.

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 8522 - 8529

Published: May 6, 2025

Language: Английский

Citations

0
Photocatalytic Hydrogenation of Alkenes Using Water as Both the Reductant and the Proton Source DOI Creative Commons

Xinzhe Tian,

Ming Qiu, Wan‐Kai An

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(44)

Published: Oct. 9, 2024

Abstract Utilization of clean and low‐cost water as the reductant to enable hydrogenation alkenes is highly attractive in green chemistry. However, this research subject considerably challenging due sluggish kinetics oxidation half‐reaction. It also very difficult avoid undesired because that far easier occur than desired from thermodynamic standpoint. Herein, challenge overcome by applying a cooperative catalysis where HCl used cocatalyst accelerate Pt/g‐C 3 N 4 ‐catalyzed suppress alkene. This provides an example for using proton source photocatalytic alkenes. The present method exhibits broad substrate applicability, allows various arylethenes aliphatic undergo smoothly.

Language: Английский

Citations

2
Ring Expansion of 3-Hydroxyoxindoles to 4-Quinolones via Palladium-Catalyzed C–C(acyl) Bond Cleavage and Subsequent Camps Cyclization DOI

Zhi-Cong Huang,

Z.J. Ruan,

Hui Xu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

We report herein the construction of 4-quinolones via palladium-catalyzed regioselective β-acyl elimination 3- hydroxyoxindoles and a subsequent Camps cyclization process.

Language: Английский

Citations

0