NIR-Triggered Programmable Nanomotor with H2S and NO Generation for Cascading Oncotherapy by Three-Pronged Reinforcing ICD
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101540 - 101540
Опубликована: Фев. 3, 2025
Язык: Английский
Minimized background tumor imaging through self-assembled disulfide dicyanine nanoparticles
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy,
Год журнала:
2025,
Номер
334, С. 125908 - 125908
Опубликована: Фев. 16, 2025
Язык: Английский
Homo‐Dyad with Outer Hydration Layer Approach for Developing NIR‐II Chromophore of High Stability and Water‐Solubility as Injectable and Sprayable Optical Probe
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(19)
Опубликована: Апрель 8, 2024
Dyes
with
extended
conjugate
structures
are
the
focus
of
extensive
design
and
synthesis
efforts,
aiming
to
confer
unique
improved
optical
electronic
properties.
Such
advancements
render
these
dyes
applicable
across
a
wide
spectrum
uses,
ranging
from
second-window
near-infrared
(NIR-II)
bioimaging
organic
photovoltaics.
Nevertheless,
inherent
benefits
long
conjugation
often
accompanied
by
persistent
challenges
like
aggregation,
fluorescence
quenching,
absorption
blueshift,
low
stability
poor
water
solubility.
Herein,
structural
strategy
termed
"homo-dyad
outer
hydration
layer"
is
introduced
address
problems,
tailored
for
development
imaging
probes
exhibiting
absorption/emission
wavelengths.
This
approach
involves
bringing
two
heptamethine
cyanines
together
through
flexible
linker,
forming
homo-dyad
structure,
while
strategically
attaching
four
polyethylene
glycol
(PEG9)
chains
terminal
heterocycles.
imparts
excellent
solubility,
biocompatibility,
enhanced
chemical,
photo-,
spectral
dyes.
Utilizing
this
strategy,
biomarker-activatable
probe
(HD-FL-4PEG9-N)
NIR-II
fluorescent
3D
multispectral
optoacoustic
tomography
developed,
its
effectiveness
in
disease
visualization.
It
can
not
only
serve
as
an
injectable
acute
kidney
injury
due
high
but
also
sprayable
bacterial-infected
wounds.
Язык: Английский
Comprehensive insights into fluorescent probes for the determination nitric oxide for diseases diagnosis
Chenqian Ye,
Shu-Fang Lin,
Jinyi Li
и другие.
Bioorganic Chemistry,
Год журнала:
2024,
Номер
150, С. 107505 - 107505
Опубликована: Май 29, 2024
Язык: Английский
Recent Advances of Versatile Fluorophores for Multifunctional Biomedical Imaging in the NIR-II Region
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Fluorescence
imaging
in
the
second
near-infrared
region
(NIR-II,
1000-1700
nm)
enables
high-resolution
visualization
of
deep-tissue
biological
architecture
and
physiopathological
events,
due
to
reduced
light
absorption,
scattering
tissue
autofluorescence.
Numerous
versatile
NIR-II
fluorescent
probes
have
been
reported
over
past
decades.
In
this
review,
we
first
provide
a
detailed
account
advantages
fluorescence
region.
Following
this,
classification,
design
performance
optimization
strategies
are
systematically
discussed,
along
with
broad
range
biomedical
applications
Язык: Английский
NIR‐II Cyazulene Fluorophores with Adjustable Cycloalkenes and Spectroscopic Properties for Imaging Applications
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 16, 2025
Abstract
NIR‐II
fluorescence
imaging
has
shown
broad
application
prospects
in
life
science
because
of
its
deeper
tissue
penetration
and
higher
spatiotemporal
resolution.
Developing
fluorophores
with
special
spectroscopic
properties
analytical
functions
become
a
cutting‐edge
but
challenging
topic
this
field.
Herein,
series
azulene‐based
(called
cyazulenes)
adjustable
cycloalkenes
for
applications
is
reported.
Cyazulenes
(CA965,
CA985,
CA1025)
are
constructed
via
the
convenient
coupling
azulene
derivatives.
They
exhibit
different
H‐aggregation
J‐aggregation.
Particularly
noteworthy
that
CA985
can
form
significant
J‐aggregates
strong
sharp
emission
biological
media,
be
used
vivo
blood
vessels
fine
structures
collecting
lymphatics
mice.
Moreover,
displays
passive
bone‐targeted
capacity,
thereby
enabling
bone
imaging.
This
study
demonstrates
chemical
impact
varying
on
aggregate
formation
spectral
cyazulenes,
which
will
advance
fluorophores.
Язык: Английский
BODIPY-Based Small Molecular Probes for Fluorescence and Photoacoustic Dual-modality Imaging of Superoxide Anion in Vivo
Talanta,
Год журнала:
2025,
Номер
294, С. 128269 - 128269
Опубликована: Май 3, 2025
Язык: Английский
Ultrasound-responsive nanoparticles for nitric oxide release to inhibit the growth of breast cancer
Cancer Cell International,
Год журнала:
2024,
Номер
24(1)
Опубликована: Дек. 28, 2024
Gas
therapy
represents
a
promising
strategy
for
cancer
treatment,
with
nitric
oxide
(NO)
showing
particular
potential
in
tumor
therapy.
However,
ensuring
sufficient
production
of
NO
remains
significant
challenge.
Leveraging
ultrasound-responsive
nanoparticles
to
promote
the
release
is
an
emerging
way
solve
this
In
study,
we
successfully
constructed
nanoparticles,
which
consisted
poly
(D,
L-lactide-co-glycolic
acid)
(PLGA)
natural
L-arginine
(LA),
and
superparamagnetic
iron
(SPIO,
Fe3O4
NPs),
denote
as
Fe3O4-LA-PLGA
NPs.
The
NPs
exhibited
effective
therapeutic
effects
both
vitro
vivo,
particularly
NO-assisted
antitumor
gas
photoacoustic
(PA)
imaging
properties.
Upon
exposure
ultrasound
irradiation,
LA
were
rapidly
released
from
PLGA
It
was
demonstrated
that
could
spontaneously
react
hydrogen
peroxide
(H2O2)
present
microenvironment
generate
Concurrently,
H2O2
produce
substantial
quantity
reactive
oxygen
species
(ROS),
can
oxidize
further
facilitate
NO.
conclusion,
proposed
delivery
platform
exhibits
effectively
inhibiting
growth
breast
cancer.
Язык: Английский
Ultrasound-responsive nanoparticles for nitric oxide release to inhibit the growth of breast cancer
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 9, 2024
Abstract
Gas
therapy
represents
a
promising
strategy
for
cancer
treatment,
with
nitric
oxide
(NO)
showing
particular
potential
in
tumor
therapy.
However,
ensuring
sufficient
production
of
NO
remains
significant
challenge.
In
this
study,
we
successfully
constructed
ultrasound-responsive
nanoparticles,
which
consisted
poly
(D,
L-lactide-co-glycolic
acid)
(PLGA)
natural
L-arginine
(LA),
and
superparamagnetic
iron
nanoparticles
(SPIO,
Fe
3O
4
NPs),
denote
as
Fe
3O
4-LA-PLGA
NPs.
The
NPs
exhibited
effective
therapeutic
effects
both
in
vitro
vivo,
particularly
NO-assisted
antitumor
gas
dual-modality
imaging
properties.
Upon
exposure
to
ultrasound
irradiation,
LA
were
rapidly
released
from
the
PLGA
It
was
demonstrated
that
could
spontaneously
react
hydrogen
peroxide
(H
2O
2)
present
microenvironment
generate
Concurrently,
H
2O
2
produce
substantial
quantity
reactive
oxygen
species
(ROS),
can
oxidize
further
facilitate
release
NO.
conclusion,
proposed
delivery
platform
exhibits
effectively
inhibiting
growth
breast
cancer.
Язык: Английский
In Vivo Targeted-Imaging of Mitochondrial Acidification in an Aristolochic Acid I-Induced Nephrotoxicity Mouse Model by a Fluorescent/Photoacoustic Bimodal Probe
Materials Today Bio,
Год журнала:
2024,
Номер
unknown, С. 101240 - 101240
Опубликована: Сен. 1, 2024
Язык: Английский