Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(19), С. 12901 - 12906
Опубликована: Май 3, 2024
Cholesterol-rich
membranes
play
a
pivotal
role
in
cancer
initiation
and
progression,
necessitating
innovative
approaches
to
target
these
for
inhibition.
Here
we
report
the
first
case
of
unnatural
peptide
(1)
assemblies
capable
depleting
cholesterol
inhibiting
cells.
Peptide
1
self-assembles
into
micelles
is
rapidly
taken
up
by
cells,
especially
when
combined
with
an
acute
cholesterol-depleting
agent
(MβCD).
Click
chemistry
has
confirmed
that
depletes
cell
membrane
cholesterol.
It
localizes
membrane-rich
organelles,
including
endoplasmic
reticulum,
Golgi
apparatus,
lysosomes.
Furthermore,
potently
inhibits
malignant
working
synergistically
cholesterol-lowering
agents.
Control
experiments
have
C-terminal
capping
amino
acid
residues
(i.e.,
BiP)
are
essential
both
depletion
potent
This
work
highlights
as
promising
platform
targeting
controlling
fates.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(47)
Опубликована: Июль 31, 2024
Abstract
Near‐infrared
photosensitizers
are
valuable
tools
to
improve
treatment
depth
in
photodynamic
therapy
(PDT).
However,
their
low
singlet
oxygen
(
1
O
2
)
generation
ability,
indicated
by
quantum
yield,
presents
a
formidable
challenge
for
PDT.
To
overcome
this
challenge,
the
heptamethine
cyanine
was
decorated
with
biocompatible
S
Scy7
and
Se
Secy7
atom.
We
observe
that
exhibits
redshift
main
absorption
~840
nm
an
ultra‐efficient
capacity.
The
emergence
of
strong
intramolecular
charge
transfer
effect
between
atom
polymethine
chain
considerably
narrows
energy
gap
(0.51
eV),
heavy
strengthens
spin–orbit
coupling
(1.44
cm
−1
),
both
which
greatly
improved
high
triplet
state
yield
(61
%),
determines
.
Therefore,
demonstrated
excellent
capacity,
is
~24.5‐fold
indocyanine
green,
~8.2‐fold
IR780,
~1.3‐fold
methylene
blue
under
low‐power‐density
850
irradiation
(5
mW
−2
).
considerable
phototoxicity
toward
cancer
cells
buried
12
mm
tissue.
Nanoparticles
formed
encapsulating
within
amphiphilic
polymers
lecithin,
promising
antitumor
anti‐pulmonary
metastatic
effects,
exhibiting
remarkable
potential
advancing
PDT
deep
tissues.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(18), С. 7257 - 7264
Опубликована: Апрель 25, 2024
Confocal
fluorescence
imaging
of
fine
structures
the
cell
membrane
is
important
for
understanding
their
biofunctions
but
often
neglected
due
to
lack
an
effective
method.
Herein,
we
develop
new
amphiphilic
rhodamine
fluorescent
probe
RMGs
in
combination
with
basal
this
purpose.
The
probes
show
high
signal-to-noise
ratio
and
brightness
low
internalization
rate,
making
them
suitable
substructures
membrane.
Using
representative
RMG3,
not
only
observed
pseudopodia
intercellular
nanotubes
also
monitored
formation
migrasomes
real
time.
More
importantly,
in-depth
studies
on
more
lines
revealed
first
time
that
hepatocellular
carcinoma
cells
secreted
much
adherent
extracellular
vesicles
than
other
lines,
which
might
serve
as
a
potential
indicator
liver
cells.
We
believe
may
be
useful
investigating
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Photodynamic
therapy
(PDT)
holds
great
potential
in
cancer
treatment,
leveraging
photosensitizers
(PSs)
to
deliver
targeted
therapy.
Fluorination
can
optimize
the
physicochemical
and
biological
properties
of
PSs
for
better
PDT
performance.
Here,
we
report
some
high-performance
multifunctional
specifically
designed
by
fluorinating
aza-BODIPY
with
perfluoro-tert-butoxymethyl
(PFBM)
groups.
plays
several
roles,
including
enhancing
selective
cell
uptake,
plasma
membrane
(PM)
targeting,
inducing
pyroptosis.
It
also
enables
fluorescence
imaging
(FLI)
fluorine-19
magnetic
resonance
(19F
MRI)
as
well
facilitates
oxygen
delivery
partial
pressure
(pO2)
measurements.
Comparative
studies,
along
molecular
dynamics
simulations,
reveal
that
fluorinated
selectively
eradicate
cells
oxidizing
PM
phospholipids
singlet
(1O2)
pyroptosis,
which
effectively
suppressed
tumor
growth
self-oxygenated
19F
MRI-FLI-guided
mice.
This
study
demonstrates
a
fluorination
strategy
tailoring
PM-targeting
materials
beyond.
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
Challenges
emerge
in
the
quest
for
highly
efficient
and
biocompatible
coatings
to
tackle
microbial
contamination.
Here,
we
propose
a
bioinspired
paradigm
combining
(-)-epigallocatechin
gallate
(EGCG)
l-arginine
surfactants
(LAM)
as
all-green
building
blocks
advanced
with
superior
performance.
Molecular
dynamics
simulations
reveal
natural
assembly
process
of
EGCG/LAM
supramolecular
nanoparticles
(ELA
NPs).
Notably,
retain
99.0%
antimicrobial
activity
even
after
eight
cycles
use
exhibit
adhesive
anti-water
washing
properties,
maintaining
their
efficacy
uses
30
days
water
soaking
on
various
substrates.
When
applied
sustainable
food
packaging
perishable
fruits
at
room
temperature,
ELA
significantly
extend
shelf
life
strawberries
cherry
tomatoes,
reducing
weight
loss
firmness
sweetness.
This
study
demonstrates
potential
NPs
versatile
durable
coating
materials
mitigating
waste
agricultural
economic
losses
due
pollution.
Nano Letters,
Год журнала:
2024,
Номер
24(46), С. 14709 - 14719
Опубликована: Ноя. 6, 2024
Pyroptosis
induced
by
photodynamic
therapy
(PDT)
is
a
promising
field
in
both
PDT
and
immunotherapy
for
tumors.
However,
effectively
inducing
tumor
cell
pyroptosis
while
triggering
strong
immune
response
using
current
photosensitizers
remains
challenging.
Herein,
the
developed
positively
charged
carbon
dots
(PCDs)
nanoPSs
were
utilized
to
modulate
first
time
through
simple
spatiotemporal
programming
strategy.
Briefly,
PCDs
enabled
precisely
time-dependent
targeting
of
membrane
or
lysosome.
Upon
light
irradiation,
Nanomaterials
have
been
vastly
used
in
daily
life.
However,
owing
to
their
unique
properties,
nanomaterials
also
show
potential
side
effects.
Among
the
various
organs
affected
by
nanomaterials,
circulatory
system
stands
out
as
particularly
vulnerable,
drawing
additional
attention
its
cardiac
toxicity.
To
address
cardiovascular
nanotoxicity
and
further
promote
safe
use
of
nanotechnology,
a
comprehensive
review
cardiotoxicity
induced
is
provided.
The
begins
identifying
current
research
trends
hotspots
this
field
via
bibliometric
analysis.
Subsequently,
based
on
objectively
obtained
hotspots,
mechanism
nanotoxicity,
including
exposure
route,
membrane
injury,
ion
disturbance,
oxidative
stress,
inflammation,
cell
death,
reviewed
discussed.
Finally,
strategies
for
mitigation
are
proposed.
objective
assist
readers
understanding
facilitate
application
human
health.
