Unnatural Peptide Assemblies Rapidly Deplete Cholesterol and Potently Inhibit Cancer Cells

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(19), P. 12901 - 12906

Published: May 3, 2024

Cholesterol-rich membranes play a pivotal role in cancer initiation and progression, necessitating innovative approaches to target these for inhibition. Here we report the first case of unnatural peptide (1) assemblies capable depleting cholesterol inhibiting cells. Peptide 1 self-assembles into micelles is rapidly taken up by cells, especially when combined with an acute cholesterol-depleting agent (MβCD). Click chemistry has confirmed that depletes cell membrane cholesterol. It localizes membrane-rich organelles, including endoplasmic reticulum, Golgi apparatus, lysosomes. Furthermore, potently inhibits malignant working synergistically cholesterol-lowering agents. Control experiments have C-terminal capping amino acid residues (i.e., BiP) are essential both depletion potent This work highlights as promising platform targeting controlling fates.

Language: Английский

---

Near–Infrared Heptamethine Cyanine Photosensitizers with Efficient Singlet Oxygen Generation for Anticancer Photodynamic Therapy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(47)

Published: July 31, 2024

Abstract Near‐infrared photosensitizers are valuable tools to improve treatment depth in photodynamic therapy (PDT). However, their low singlet oxygen ( 1 O 2 ) generation ability, indicated by quantum yield, presents a formidable challenge for PDT. To overcome this challenge, the heptamethine cyanine was decorated with biocompatible S Scy7 and Se Secy7 atom. We observe that exhibits redshift main absorption ~840 nm an ultra‐efficient capacity. The emergence of strong intramolecular charge transfer effect between atom polymethine chain considerably narrows energy gap (0.51 eV), heavy strengthens spin–orbit coupling (1.44 cm −1 ), both which greatly improved high triplet state yield (61 %), determines . Therefore, demonstrated excellent capacity, is ~24.5‐fold indocyanine green, ~8.2‐fold IR780, ~1.3‐fold methylene blue under low‐power‐density 850 irradiation (5 mW −2 ). considerable phototoxicity toward cancer cells buried 12 mm tissue. Nanoparticles formed encapsulating within amphiphilic polymers lecithin, promising antitumor anti‐pulmonary metastatic effects, exhibiting remarkable potential advancing PDT deep tissues.

Language: Английский

---

Fluorination of Aza-BODIPY for Cancer Cell Plasma Membrane-Targeted Imaging and Therapy

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Photodynamic therapy (PDT) holds great potential in cancer treatment, leveraging photosensitizers (PSs) to deliver targeted therapy. Fluorination can optimize the physicochemical and biological properties of PSs for better PDT performance. Here, we report some high-performance multifunctional specifically designed by fluorinating aza-BODIPY with perfluoro-tert-butoxymethyl (PFBM) groups. plays several roles, including enhancing selective cell uptake, plasma membrane (PM) targeting, inducing pyroptosis. It also enables fluorescence imaging (FLI) fluorine-19 magnetic resonance (19F MRI) as well facilitates oxygen delivery partial pressure (pO2) measurements. Comparative studies, along molecular dynamics simulations, reveal that fluorinated selectively eradicate cells oxidizing PM phospholipids singlet (1O2) pyroptosis, which effectively suppressed tumor growth self-oxygenated 19F MRI-FLI-guided mice. This study demonstrates a fluorination strategy tailoring PM-targeting materials beyond.

Language: Английский

---

Bioinspired Assembly of Natural Polyphenol-Amino Acid Surfactants as Multifunctional Durable Coatings for Anticorrosion Fruit Packaging

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Challenges emerge in the quest for highly efficient and biocompatible coatings to tackle microbial contamination. Here, we propose a bioinspired paradigm combining (-)-epigallocatechin gallate (EGCG) l-arginine surfactants (LAM) as all-green building blocks advanced with superior performance. Molecular dynamics simulations reveal natural assembly process of EGCG/LAM supramolecular nanoparticles (ELA NPs). Notably, retain 99.0% antimicrobial activity even after eight cycles use exhibit adhesive anti-water washing properties, maintaining their efficacy uses 30 days water soaking on various substrates. When applied sustainable food packaging perishable fruits at room temperature, ELA significantly extend shelf life strawberries cherry tomatoes, reducing weight loss firmness sweetness. This study demonstrates potential NPs versatile durable coating materials mitigating waste agricultural economic losses due pollution.

Language: Английский

---

Amphiphilic Rhodamine Fluorescent Probes Combined with Basal Imaging for Fine Structures of the Cell Membrane

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(18), P. 7257 - 7264

Published: April 25, 2024

Confocal fluorescence imaging of fine structures the cell membrane is important for understanding their biofunctions but often neglected due to lack an effective method. Herein, we develop new amphiphilic rhodamine fluorescent probe RMGs in combination with basal this purpose. The probes show high signal-to-noise ratio and brightness low internalization rate, making them suitable substructures membrane. Using representative RMG3, not only observed pseudopodia intercellular nanotubes also monitored formation migrasomes real time. More importantly, in-depth studies on more lines revealed first time that hepatocellular carcinoma cells secreted much adherent extracellular vesicles than other lines, which might serve as a potential indicator liver cells. We believe may be useful investigating

Language: Английский

---

Synergism of rotary motor and twisted framework in NIR absorbing aza-BODIPY for photothermal-photodynamic therapy

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 44, P. 102547 - 102547

Published: Jan. 25, 2025

Language: Английский

---

Understanding the Mechanism of Cardiotoxicity Induced by Nanomaterials: A Comprehensive Review

Small Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Nanomaterials have been vastly used in daily life. However, owing to their unique properties, nanomaterials also show potential side effects. Among the various organs affected by nanomaterials, circulatory system stands out as particularly vulnerable, drawing additional attention its cardiac toxicity. To address cardiovascular nanotoxicity and further promote safe use of nanotechnology, a comprehensive review cardiotoxicity induced is provided. The begins identifying current research trends hotspots this field via bibliometric analysis. Subsequently, based on objectively obtained hotspots, mechanism nanotoxicity, including exposure route, membrane injury, ion disturbance, oxidative stress, inflammation, cell death, reviewed discussed. Finally, strategies for mitigation are proposed. objective assist readers understanding facilitate application human health.

Language: Английский

---

Surfactant Mediated Dispersion and stabilization of nano-emulsion droplets enhance antimicrobial activity against multidrug resistant bacteria

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: 426, P. 127300 - 127300

Published: March 6, 2025

Language: Английский

---

A cyanine fluorophore for imaging-guided tumor photodynamic and photothermal therapy under NIR-II light activation

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

---

In situ peptide assembly for cell membrane rewiring in tumor therapy

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113637 - 113637

Published: March 1, 2025

Language: Английский

---