Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Язык: Английский

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Atomic Interface Engineering‐Mediated Metallene Nanozyme Boosts Efficient Photothermal Catalytic Tumor‐Specific Therapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(46)

Опубликована: Авг. 2, 2024

Abstract Tumor microenvironment (TME)‐responsive nanozymes‐based catalytic therapy shows great potential in combating malignant tumor. However, their biological application still suffers from deficient activity. Herein, the MoO x ‐Rh metallene nanozyme demonstrates highly efficient multiple enzymatic activities, where species atomically dispersed on Rh surface. The resulting structures enable with maximally exposed active oxide‐metallene interface and more atoms sites around can be well finely regulated. Results of experiment density functional theory (DFT) simulations support notion that atomic structure facilitates enzyme‐like reactions. As a TME‐responsive nanozyme, exhibits remarkable therapeutic effect tumor due to intrinsic near‐infrared photothermal laser‐enhanced activities. This study illustrates promise engineering strategy therapy.

Язык: Английский

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Site‐Specific for CO₂ Photoreduction with Single‐Atom Ni on Strained TiO_2−x Derived from Bimetallic Metal–Organic Frameworks

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Abstract The photocatalytic reduction of CO 2 in water to produce fuels and chemicals is promising while challenging. However, many photocatalysts for accomplishing such challenging task usually suffer from unspecific catalytic active sites the inefficient charge carrier's separation. Here, a site‐specific single‐atom Ni/TiO 2−x catalyst reported by situ topological transformation Ni‐Ti‐EG bimetallic metal–organic frameworks. loading nickel nanoparticles or individual atoms, which act as specific sites, can be precisely regulated chelating agents through partial removal adjacent oxygen atoms. Furthermore, degree lattice strain catalysts, improves separation efficiency carriers, modulated fine‐tuning process. By leveraging anchored atoms strained TiO , optimized Ni SA0.27 /TiO shows generation rate 86.3 µmol g −1 h (288 times higher than that NPs ) selectivity up 92.5% pure‐water system. This work underscores importance tailoring creating facilitate efficient selective .

Язык: Английский

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Recent advances in chemodynamic nanotherapeutics to overcome multidrug resistance in cancers

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 184, С. 117901 - 117901

Опубликована: Фев. 11, 2025

Язык: Английский

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Ultrasensitive Electrochemical Screening of Circulating Tumor Cells Over Single‐Atom Nanozyme Integrated 3D Nanoarray

Small, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Late-stage diagnosis is a major contributor to cancer mortality and thus leads increased fatality, making early detection crucial for improving survival rates. Circulating tumor cells (CTC), detectable before primary tumors become clinically apparent, have emerged as vital biomarkers the identification of aggressive cancers. Here, develop single-atom nanozyme integrated nanoarray 3D nano-biointerface ultrasensitive electrochemical screening CTCs from hepatocellular carcinoma. This cytosensor capable identifying CTC at single-cell level, achieving an impressive area under curve 0.96 in receiver operating characteristics, comparable simulated multi-indicator diagnostic strategies. strategy shows great potential non-invasive carcinoma promising be applied universally diagnosis.

Язык: Английский

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Hetero‐Trimetallic Atom Catalysts Enable Targeted ROS Generation and Redox Signaling for Intensive Apoptosis and Ferroptosis

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 23, 2025

Abstract Reactive oxygen species (ROS) play crucial roles in cellular metabolic processes by acting as primary intracellular chemical substrates and secondary messengers for signal modulation. However, the artificial engineering of nanozymes to generate ROS is restricted their low catalytic efficiency, high toxicity, off‐target consumption. Herein, hetero‐trimetallic atom catalysts (TACs) anchored on a stable symmetrical pyramid structure are designed presence N P surface ligands from cross‐linked polyphosphazene interlayer‐coated MIL‐101(Fe). The 3D network TACs with uniform dispersion Cu, Co, Fe hetero‐single atoms effectively tailor active sites avoid metal sintering, thereby providing sufficient activity blooms. Nanovesicle membranes facilitate accumulation homologous targeting, recognition, endocytosis, addressing potentially toxicity defects. Therefore, outcome situ ROS‐bloom acts redox directly regulating oxidative stress tumor microenvironment. Meanwhile, intervene glutathione peroxidase 4, long‐chain acyl‐CoA synthetase cysteinyl aspartate specific proteinase‐3 pathways second messengers, fostering proclivity toward apoptosis lipid peroxidation‐regulated ferroptosis pathway concurrently, highlighting application prospects biomedical field.

Язык: Английский

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Surface Engineering‐Induced d‐Band Center Down‐Regulation in High‐Entropy Alloy Nanowires for Enhanced Nanozyme Catalysis

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Abstract High‐entropy alloys (HEAs) have garnered extensive attention owing to their broad compositional tunability and high catalytic activity. However, precisely modulating the enzyme‐like activity of HEAs enhancing biocompatibility for biological applications remain severely challenging. Herein, PtRuFeCoNi HEA nanowires (NWs) are synthesized by adjusting metal composition surface‐engineered with polydopamine (PDA) form NWs@PDA nanozymes (HEzymes@PDA) superior photothermal properties. Density functional theory calculations Sabatier principle reveal that self‐polymerized PDA surface engineering moderately lowers d‐band center HEAs, optimizes charge distribution, enhances adsorption–desorption efficiency substrates. As a proof‐of‐concept, HEzymes@PDA synergistically integrated hydrogels biosensing analysis. This study presents an innovative paradigm designing highly active via demonstrates immense potential in sensing applications.

Язык: Английский

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A Glucose-based Porous Organic Polymer Artificial Enzyme with Dual Mimicking-enzyme Activities for Wound Therapy via Reshaping the Infectious Microenvironment

Surfaces and Interfaces, Год журнала: 2025, Номер unknown, С. 106432 - 106432

Опубликована: Апрель 1, 2025

Язык: Английский

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Bimetallic nanozymes with robust antibacterial effects for infected wound healing through diverse metal-precise regulation strategies

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163016 - 163016

Опубликована: Апрель 1, 2025

Язык: Английский

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Camouflaged Nanozymes with Oxidation‐Promoting Activities Triggering Ferroptosis for Radio‐Immunotherapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

Abstract Radioresistance presents a substantial obstacle to achieving optimal therapeutic outcomes for breast cancer treatment. In this study, we develop cell membrane (CM) ‐ coated nanozyme system (MPPC@CM), specifically designed radioimmunotherapy address issue. This innovative involves the in situ reduction of platinum and palladium on mesoporous silica nanospheres, followed by functionalization with cinnamaldehyde via surface grafting. The CM coating endows enhanced tumor‐specific targeting capability due its homing properties. Upon uptake tumor cells, MPPC@CM catalytically generates O 2 from H , mitigating hypoxic microenvironment reducing radioresistance. intracellular glutathione depletion mediated Michael addition reactions concurrently disrupts endogenous antioxidant defenses against reactive oxygen species (ROS). redox imbalance is synergistically amplified through nanozyme‐mediated catalytic activities including both peroxidase‐like oxidase‐like functions. resultant massive ROS accumulation establishes self‐reinforcing oxidative cascade that ultimately induces functional inactivation peroxidase 4. immunosuppressive environment remodeled disturbance balance, which accelerates ferroptosis increases CD8 + T‐cell infiltration dendritic maturation. Overall, membrane‐camouflaged holds significant potential enhance efficacy radioimmunotherapy.

Язык: Английский

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