Synthesis of Axially Chiral Monofluoroalkenes via Nickel-Catalyzed Reductive Cross-Coupling of gem-Difluoroalkenes DOI
Tiantian Yin, Ming Yu Jin, Tiantian Zhao

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Сен. 13, 2024

Enantioenriched monofluoroalkenes are important structural motifs in life science and functional materials. To date, only limited strategies were reported for the synthesis of with stereogenic carbon centers; axially chiral counterpart is still highly desirable. Herein, we report Ni-catalyzed defluorinative cross-electrophile coupling

Язык: Английский

First synthesis of (difluoroiodomethyl)thiophenes through double iodation of 2-(difluoromethylene)but-3-yn-1-yl benzyl sulfides DOI

Daiki Komatsu,

Takeshi Hanamoto

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Double iodation of enyne sulfides in a mixed solvent (CHCl 3 /EtOH = 50/1) provided promising 4-(difluoroiodomethyl)-3-iodo-2-substituted thiophenes good to excellent yields.

Язык: Английский

Процитировано

0
Recent Advances in Transition-Metal Catalyzed C—H Bond Activation for the Synthesis of C(sp3)-Fluoroalkyl Compounds DOI
Manman Wang, Wenhui Xi, Hao Wu

и другие.

Chinese Journal of Organic Chemistry, Год журнала: 2025, Номер 45(2), С. 516 - 516

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Cu(II)/Photoredox-Catalyzed Aminoacylation of Vinyl Bromides DOI
Guojin Huang, Huanfeng Jiang, Qiang Zeng

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

A novel C–C coupling reaction of vinyl bromides with carboxamides has been developed through Cu(OAc)2/photocatalysis. This process features regioselective carboxamido carbon-vinylation under mild conditions. Mechanistic studies suggest that the formation an acyl-Cu(I) intermediate plays a crucial role regard to enabling this transformation.

Язык: Английский

Процитировано

0
Copper-Catalyzed Regio- and Enantioselective Hydroamination of gem-Difluoroalkenes to Access Chiral Difluoromethyl Amines DOI
Ming Yu Jin, Yuanyuan Guo, Hao Wu

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

The difluoromethyl group (CF2H) is an important motif in medicinal chemistry. We report the efficient synthesis of a range optically pure α-difluoromethyl amines via copper-catalyzed regio- and enantioselective hydroamination gem-difluoroalkenes. application chiral pyridine-derived ligand inhibits β-F elimination from α-CF2H organocopper intermediate. proposed Cu catalyst promotes production by Cu-H insertion reductive C-N bond using readily available materials. findings this study establish new synthetic strategy to access motifs.

Язык: Английский

Процитировано

0
Photoinduced Metal‐Free Decarboxylative Fluoroalkylation of Alkenes for the Synthesis of N‐Arylbutanamides and Oxindoles DOI

Yi‐Gang Ji,

Z. Li,

Yuqing Yang

и другие.

Chemistry - A European Journal, Год журнала: 2024, Номер 30(68)

Опубликована: Авг. 28, 2024

The visible light-induced decarboxylative cascade reaction of fluoroalkyl carboxylic acids has been achieved for the efficient synthesis fluorinated compounds. However, most transformations rely on noble iridium metal complex. Herein, a metal-free realized. This protocol features simple operation, transition free, and good functional group tolerance.

Язык: Английский

Процитировано

2
Synthesis of Axially Chiral Monofluoroalkenes via Nickel-Catalyzed Reductive Cross-Coupling of gem-Difluoroalkenes DOI
Tiantian Yin, Ming Yu Jin, Tiantian Zhao

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Сен. 13, 2024

Enantioenriched monofluoroalkenes are important structural motifs in life science and functional materials. To date, only limited strategies were reported for the synthesis of with stereogenic carbon centers; axially chiral counterpart is still highly desirable. Herein, we report Ni-catalyzed defluorinative cross-electrophile coupling

Язык: Английский

Процитировано

1