Synthesis of Axially Chiral Monofluoroalkenes via Nickel-Catalyzed Reductive Cross-Coupling of gem-Difluoroalkenes DOI
Tiantian Yin, Ming Yu Jin, Tiantian Zhao

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Enantioenriched monofluoroalkenes are important structural motifs in life science and functional materials. To date, only limited strategies were reported for the synthesis of with stereogenic carbon centers; axially chiral counterpart is still highly desirable. Herein, we report Ni-catalyzed defluorinative cross-electrophile coupling

Language: Английский

First synthesis of (difluoroiodomethyl)thiophenes through double iodation of 2-(difluoromethylene)but-3-yn-1-yl benzyl sulfides DOI

Daiki Komatsu,

Takeshi Hanamoto

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Double iodation of enyne sulfides in a mixed solvent (CHCl 3 /EtOH = 50/1) provided promising 4-(difluoroiodomethyl)-3-iodo-2-substituted thiophenes good to excellent yields.

Language: Английский

Citations

0
Recent Advances in Transition-Metal Catalyzed C—H Bond Activation for the Synthesis of C(sp3)-Fluoroalkyl Compounds DOI
Manman Wang, Wenhui Xi, Hao Wu

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 45(2), P. 516 - 516

Published: Jan. 1, 2025

Language: Английский

Citations

0
Cu(II)/Photoredox-Catalyzed Aminoacylation of Vinyl Bromides DOI
Guojin Huang, Huanfeng Jiang, Qiang Zeng

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

A novel C–C coupling reaction of vinyl bromides with carboxamides has been developed through Cu(OAc)2/photocatalysis. This process features regioselective carboxamido carbon-vinylation under mild conditions. Mechanistic studies suggest that the formation an acyl-Cu(I) intermediate plays a crucial role regard to enabling this transformation.

Language: Английский

Citations

0
Photoinduced Metal‐Free Decarboxylative Fluoroalkylation of Alkenes for the Synthesis of N‐Arylbutanamides and Oxindoles DOI

Yi‐Gang Ji,

Z. Li,

Yuqing Yang

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(68)

Published: Aug. 28, 2024

The visible light-induced decarboxylative cascade reaction of fluoroalkyl carboxylic acids has been achieved for the efficient synthesis fluorinated compounds. However, most transformations rely on noble iridium metal complex. Herein, a metal-free realized. This protocol features simple operation, transition free, and good functional group tolerance.

Language: Английский

Citations

1
Synthesis of Axially Chiral Monofluoroalkenes via Nickel-Catalyzed Reductive Cross-Coupling of gem-Difluoroalkenes DOI
Tiantian Yin, Ming Yu Jin, Tiantian Zhao

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Enantioenriched monofluoroalkenes are important structural motifs in life science and functional materials. To date, only limited strategies were reported for the synthesis of with stereogenic carbon centers; axially chiral counterpart is still highly desirable. Herein, we report Ni-catalyzed defluorinative cross-electrophile coupling

Language: Английский

Citations

0