Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Low immunogenicity and insufficient infiltration of immune cells are the main factors affecting therapeutic efficacy melanoma immunotherapy. Ultrasound-triggered sonodynamic therapy (SDT) based on piezoelectric materials has attracted substantial attention due to its high efficiency catalytic generation reactive oxygen species (ROS) induce immunogenic cell death (ICD). However, hypoxic environment in solid tumors hinders limits SDT effect. Herein, we construct a novel Ir-C3N5 nanocomplex that uses nitrogen-rich carbon nitride (C3N5) nanosheets as nanoligands Ir(tpy)Cl3 precursor. The newly formed exhibits narrowed band gap an enlarged dipole moment, resulting better electron-hole pair separation bending, contributing ROS burst upon ultrasonic activation. In addition, Ir(III) enables C3N5 catalyze degradation H2O2 O2, alleviating tumor hypoxia reinforcing efficacy. Mechanistically, by catalysis, can target lysosomes trigger autophagy inhibition caused lysosome rupture evoke pyroptosis. More importantly, cleaved caspase-1/GSDMD-N pyroptosis pathway activated was associated with ICD, effectively initiating innate adaptive immunity body for suppressing metastasis relapse.

Language: Английский