Forensic application of sandpaper spray ionization mass spectrometry (SPS‐MS): Direct analysis of solid pharmaceutical formulations and edible cannabis products

Journal of Forensic Sciences, Год журнала: 2024, Номер 69(6), С. 2209 - 2221

Опубликована: Авг. 5, 2024

In this work, we employed a new ambient ionization mass spectrometry technique, sandpaper spray (SPS-MS), as an efficient tool to analyze pills and tablets of pharmaceutical formulations. The following samples were analyzed: regulators blood pressure, cholesterol, diabetes, drugs for the treatment erectile dysfunction (ED). Additionally, hard candy Cannabis sativa containing Δ9-tetrahydrocannabinol (Δ

Язык: Английский

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Enhanced Sensitivity and Homogeneity of SERS Signals on Plasmonic Substrate When Coupled to Paper Spray Ionization–Mass Spectrometry

Chemosensors, Год журнала: 2024, Номер 12(9), С. 175 - 175

Опубликована: Сен. 2, 2024

This work reports on the development of an analyte sampling strategy a plasmonic substrate to amplify detection capability dual analytical system, paper spray ionization–mass spectrometry (PSI-MS) and surface-enhanced Raman spectroscopy (SERS). While simply applying only solution results in limited degree SERS enhancement, introduction gold nanoparticles (AuNPs) greatly improves signals without sacrificing PSI-MS sensitivity. It is initially revealed that concentration AuNPs type analytes highly influence their variations due “coffee ring effect” flow mechanism induced during interfacial interactions (e.g., van der Waals, electrostatic, covalent) between analyte. Subsequent PSI treatment at high voltage conditions further impacts overall responses, where signal sensitivity homogeneity significantly increase throughout entire substrate, suggesting ready migration adsorbed regardless attractive forces. The PSI-induced notable enhancements are presumably associated with creating unique for local aggregation induce effective couplings hot spots (i.e., electromagnetic effect) repositioning close proximity surface polarizability chemical effect). optimized also applicable multi-analyte analysis by MS, enhanced uniformity.

Язык: Английский

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Magnetic particle spray mass spectrometry for the determination of beta-blockers in plasma samples

Microchimica Acta, Год журнала: 2024, Номер 191(10)

Опубликована: Сен. 25, 2024

Язык: Английский

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Rapid desorption and analysis for illicit drugs and chemical profiling of fingerprints by SICRIT ion source

Drug Testing and Analysis, Год журнала: 2023, Номер 16(10), С. 1094 - 1101

Опубликована: Дек. 28, 2023

Forensic analysis can encompass a wide variety of analytes from biological samples including DNA, blood, serum, and fingerprints to synthetic like drugs explosives. In order analyze this variety, there are various sample preparation techniques, which be time-consuming require multiple analytical instruments. With recent advancements in ambient ionization mass spectrometry (MS), plasma-based dielectric barrier discharge (DBDI) sources have demonstrated cover range these analytes. The flow-through design source also allows for easy connection thermal desorption type introduction. We present an in-house built device where the is introduced via glass slide, gets heated transferred DBDI-MS with nitrogen identification semi-quantification. Using slide as inexpensive sampling device, detection limits low 20 pg fentanyl demonstrated. Additionally, very precise (>96% accuracy) persons based on chemical profile their possible, establishing direct link drug trace individual one measurement. compared DAG, TAG, sterol, (semi-)volatile region averaged fingerprint spectra over days, showing best model accuracy DAG region. combination minimized preparation, leading ultrasensitive rapid illicit traces underlying personas fingerprints.

Язык: Английский

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Chemical tools and chemometrics to uncover geographical indication

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 321 - 354

Опубликована: Янв. 1, 2024

Язык: Английский

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