The Current Landscape of 1,2,3‐triazole Hybrids With Anticancer Therapeutic Potential: Part II

Archiv der Pharmazie, Год журнала: 2025, Номер 358(4)

Опубликована: Апрель 1, 2025

Chemotherapy has been identified as a validated and critically important strategy for the treatment of cancer, but multidrug resistance serious side effects remain grand challenges effective cancer therapy. This highlights urgent need development alternative chemical entities that can modulate more than one biological target with high specificity multitargeted mechanism action in disease progression pathway. 1,2,3-Triazole hybrids have potential to act on dual/multiple targets cells simultaneously possess potent broad-spectrum activity against various cancers, including drug-resistant forms. Thus, 1,2,3-triazole are valuable scaffolds eradication cancer. review provides comprehensive overview evolving landscape their vitro vivo anticancer potential, structure-activity relationships well mechanisms also discussed, covering articles published from 2021 onward.

Язык: Английский

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Recent advances in the green synthesis of indole and its derivatives using microwave irradiation and the role of indole moiety in cancer

Green Chemistry Letters and Reviews, Год журнала: 2024, Номер 17(1)

Опубликована: Июль 16, 2024

Indole moiety is widely present in several natural bioactive products and medicinally important compounds. It an essential scaffold for the development of novel leads. Nowadays, synthesis indoles by conventional methods replaced with greener ones. The dynamic growth green organic synthetic approaches different heterocyclic scaffolds has markedly contributed to field medicinal chemistry over last few decades. This review article compiled seven years' results indole its derivatives using microwave irradiations from 2018 2024. Microwave (MW) assisted reactions are very rapid, environment-friendly, proficient, convenient methodologies contains procedures, reaction conditions, features synthesizing derivatives. aims promote guide researchers design, develop, synthesize indole-based a irradiation technique. also discusses anticancer potential indole-containing compounds reported recent literature.

Язык: Английский

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Synthesis of 4-(3-(1-substituted/unsubstituted-phenyl-1H-1,2,3-triazole-4-yl)propoxy)benzaldehydes: In vitro antimicrobial, antimalarial activities and In silico docking study

Journal of Molecular Structure, Год журнала: 2024, Номер 1317, С. 139006 - 139006

Опубликована: Июнь 18, 2024

Язык: Английский

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1,2,3-Triazole based xanthene and acridine linkers as potential α-glucosidase and α-amylase inhibitors: design, green synthesis, kinetics, and in silico studies

Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 141196 - 141196

Опубликована: Дек. 1, 2024

Язык: Английский

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