1,2,3-Triazole based xanthene and acridine linkers as potential α-glucosidase and α-amylase inhibitors: design, green synthesis, kinetics, and in silico studies DOI

Reena C. Patel,

Chetan V. Rajput, Manish P. Patel

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 141196 - 141196

Published: Dec. 1, 2024

Language: Английский

The Current Landscape of 1,2,3‐triazole Hybrids With Anticancer Therapeutic Potential: Part II DOI

Zhi Xu,

Junna Liu

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(4)

Published: April 1, 2025

Chemotherapy has been identified as a validated and critically important strategy for the treatment of cancer, but multidrug resistance serious side effects remain grand challenges effective cancer therapy. This highlights urgent need development alternative chemical entities that can modulate more than one biological target with high specificity multitargeted mechanism action in disease progression pathway. 1,2,3-Triazole hybrids have potential to act on dual/multiple targets cells simultaneously possess potent broad-spectrum activity against various cancers, including drug-resistant forms. Thus, 1,2,3-triazole are valuable scaffolds eradication cancer. review provides comprehensive overview evolving landscape their vitro vivo anticancer potential, structure-activity relationships well mechanisms also discussed, covering articles published from 2021 onward.

Language: Английский

Citations

0
Recent advances in the green synthesis of indole and its derivatives using microwave irradiation and the role of indole moiety in cancer DOI Creative Commons
Faisal A. Almalki,

Alaa O. Baryyan

Green Chemistry Letters and Reviews, Journal Year: 2024, Volume and Issue: 17(1)

Published: July 16, 2024

Indole moiety is widely present in several natural bioactive products and medicinally important compounds. It an essential scaffold for the development of novel leads. Nowadays, synthesis indoles by conventional methods replaced with greener ones. The dynamic growth green organic synthetic approaches different heterocyclic scaffolds has markedly contributed to field medicinal chemistry over last few decades. This review article compiled seven years' results indole its derivatives using microwave irradiations from 2018 2024. Microwave (MW) assisted reactions are very rapid, environment-friendly, proficient, convenient methodologies contains procedures, reaction conditions, features synthesizing derivatives. aims promote guide researchers design, develop, synthesize indole-based a irradiation technique. also discusses anticancer potential indole-containing compounds reported recent literature.

Language: Английский

Citations

2
Synthesis of 4-(3-(1-substituted/unsubstituted-phenyl-1H-1,2,3-triazole-4-yl)propoxy)benzaldehydes: In vitro antimicrobial, antimalarial activities and In silico docking study DOI

Mohammed A. Al-Salehi,

Mehul P. Parmar, Dhanji P. Rajani

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1317, P. 139006 - 139006

Published: June 18, 2024

Language: Английский

Citations

0
1,2,3-Triazole based xanthene and acridine linkers as potential α-glucosidase and α-amylase inhibitors: design, green synthesis, kinetics, and in silico studies DOI

Reena C. Patel,

Chetan V. Rajput, Manish P. Patel

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 141196 - 141196

Published: Dec. 1, 2024

Language: Английский

Citations

0