Design of novel benzimidazole-propane hydrazide derivatives as α-glucosidase and α-amylase inhibitors: in vitro and in silico studies DOI

Shiva Mohammadizadeh,

Somaye Karimian,

Navid Dastyafteh

и другие.

Medicinal Chemistry Research, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 9, 2024

Язык: Английский

Design, synthesis, in-vitro and in-silico studies of 6-bromochromone based thiosemicarbazones as α-glucosidase inhibitors DOI

Kholood A. Dahlous,

Muhammad Ajmal,

Naeem Ullah

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141374 - 141374

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Design, synthesis, in-vitro and in-silico studies of novel N-heterocycle based hydrazones as α-glucosidase inhibitors DOI

Rehmatullah Farooqi,

Naeem Ullah,

Ajmal Khan

и другие.

Bioorganic Chemistry, Год журнала: 2025, Номер 156, С. 108155 - 108155

Опубликована: Янв. 10, 2025

Язык: Английский

Процитировано

1
A glance into Schiff-based α-glucosidase inhibitors in medicinal chemistry DOI
Sakineh Dadashpour

Medicinal Chemistry Research, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Язык: Английский

Процитировано

0
Synthesis, in vitro, and in silico studies of 7-fluorochromone based thiosemicarbazones as α-glucosidase inhibitors DOI Creative Commons

Faiqa Noreen,

Naeem Ullah, Suraj N. Mali

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 21, 2025

Increased blood sugar is a typical manifestation of Type-2 Diabetes Mellitus (T2DM), metabolic disorder that can be effectively managed with the help α-glucosidase inhibitors. A range new chromone based thiosemicarbazone derivatives (3a-t) was synthesized and assessed due to their ability suppress in this research. Having IC50 values spanning from 6.40 ± 0.15 62.81 0.79 μM, compounds demonstrated strong inhibitory actions. The compound 3 k showed most effect among all them, by an measurement µM. It concluded through structure–activity relationship (SAR) assessment various substituents on moieties had significant impact differences inhibition. Molecular docking experiments provide light important interactions, including π-π interactions hydrogen bridges, between role carbothioamide chromenyl groups ligand attachment critical residues α-glucosidase. binding alignment, stability, structural arrangement prepared molecules catalytic pocket were explored using silico strategies such as studies, pharmacokinetic analysis, molecular dynamics simulations. This investigation directed find favorable profiles for future progress potential therapeutic agents type 2 diabetes. Importantly, when benchmarking against acarbose, lead candidate substantially greater efficacy.

Язык: Английский

Процитировано

0
Design of novel benzimidazole-propane hydrazide derivatives as α-glucosidase and α-amylase inhibitors: in vitro and in silico studies DOI

Shiva Mohammadizadeh,

Somaye Karimian,

Navid Dastyafteh

и другие.

Medicinal Chemistry Research, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 9, 2024

Язык: Английский

Процитировано

0