Design of novel benzimidazole-propane hydrazide derivatives as α-glucosidase and α-amylase inhibitors: in vitro and in silico studies DOI

Shiva Mohammadizadeh,

Somaye Karimian,

Navid Dastyafteh

et al.

Medicinal Chemistry Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Language: Английский

Design, synthesis, in-vitro and in-silico studies of 6-bromochromone based thiosemicarbazones as α-glucosidase inhibitors DOI

Kholood A. Dahlous,

Muhammad Ajmal,

Naeem Ullah

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141374 - 141374

Published: Jan. 1, 2025

Language: Английский

Citations

2
Design, synthesis, in-vitro and in-silico studies of novel N-heterocycle based hydrazones as α-glucosidase inhibitors DOI

Rehmatullah Farooqi,

Naeem Ullah,

Ajmal Khan

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 156, P. 108155 - 108155

Published: Jan. 10, 2025

Language: Английский

Citations

1
A glance into Schiff-based α-glucosidase inhibitors in medicinal chemistry DOI
Sakineh Dadashpour

Medicinal Chemistry Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Synthesis, in vitro, and in silico studies of 7-fluorochromone based thiosemicarbazones as α-glucosidase inhibitors DOI Creative Commons

Faiqa Noreen,

Naeem Ullah, Suraj N. Mali

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 21, 2025

Increased blood sugar is a typical manifestation of Type-2 Diabetes Mellitus (T2DM), metabolic disorder that can be effectively managed with the help α-glucosidase inhibitors. A range new chromone based thiosemicarbazone derivatives (3a-t) was synthesized and assessed due to their ability suppress in this research. Having IC50 values spanning from 6.40 ± 0.15 62.81 0.79 μM, compounds demonstrated strong inhibitory actions. The compound 3 k showed most effect among all them, by an measurement µM. It concluded through structure–activity relationship (SAR) assessment various substituents on moieties had significant impact differences inhibition. Molecular docking experiments provide light important interactions, including π-π interactions hydrogen bridges, between role carbothioamide chromenyl groups ligand attachment critical residues α-glucosidase. binding alignment, stability, structural arrangement prepared molecules catalytic pocket were explored using silico strategies such as studies, pharmacokinetic analysis, molecular dynamics simulations. This investigation directed find favorable profiles for future progress potential therapeutic agents type 2 diabetes. Importantly, when benchmarking against acarbose, lead candidate substantially greater efficacy.

Language: Английский

Citations

0
Design of novel benzimidazole-propane hydrazide derivatives as α-glucosidase and α-amylase inhibitors: in vitro and in silico studies DOI

Shiva Mohammadizadeh,

Somaye Karimian,

Navid Dastyafteh

et al.

Medicinal Chemistry Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Language: Английский

Citations

0