Analytica Chimica Acta, Год журнала: 2024, Номер 1303, С. 342528 - 342528
Опубликована: Март 25, 2024
Язык: Английский
Chemical Society Reviews, Год журнала: 2022, Номер 51(4), С. 1277 - 1335
Опубликована: Янв. 1, 2022
The review summarizes the exploitations of corrole derivatives in many different fields, where peculiar properties these contracted macrocycles lead to development promising applications.
Язык: Английский
Процитировано
108
npj Imaging, Год журнала: 2024, Номер 2(1)
Опубликована: Июль 17, 2024
Abstract The recent upswing in the integration of spatial multi-omics for conducting multidimensional information measurements is opening a new chapter biological research. Mapping landscape various biomolecules including metabolites, proteins, nucleic acids, etc., and even deciphering their functional interactions pathways believed to provide more holistic nuanced exploration molecular intricacies within living systems. Mass spectrometry imaging (MSI) stands as forefront technique spatially mapping metabolome, lipidome, proteome diverse tissue cell samples. In this review, we offer systematic survey delineating different MSI techniques resolved analysis, elucidating principles, capabilities, limitations. Particularly, focus on advancements methodologies aimed at augmenting sensitivity specificity MSI; depict burgeoning MSI-based metabolomics, lipidomics, proteomics, encompassing synergy with other modalities. Furthermore, speculative insights into potential trajectory technology future.
Язык: Английский
Процитировано
19
Chemistry - An Asian Journal, Год журнала: 2021, Номер 16(8), С. 868 - 878
Опубликована: Март 3, 2021
Abstract The analysis of low molecular weight (LMW) compounds is great interest to detect small pharmaceutical drugs rapidly and sensitively, or trace understand metabolic pathways. Matrix‐assisted laser desorption/ionization mass spectrometry (MALDI MS) plays a central role in the high (bio)molecules. However, its application for LMW restricted by spectral interferences m/z region, which are produced conventional organic matrices. Several strategies regarding sample preparation have been investigated overcome this problem. A different rationale centred on developing new matrices not only meet fundamental requirements good absorption ionization efficiency, but also vacuum stable “MALDI silent”, i. e., do give matrix‐related signals area. This review gives an overview rational design used develop matrix systems compounds, focusing (i) modification well‐known matrices, (ii) search (iii) development binary, hybrid nanomaterial‐based (iv) advance reactive (v) progress made negative dual polarity mode.
Язык: Английский
Процитировано
52
Metabolomics, Год журнала: 2022, Номер 18(10)
Опубликована: Окт. 1, 2022
Язык: Английский
Процитировано
32
Biomolecules, Год журнала: 2023, Номер 13(3), С. 546 - 546
Опубликована: Март 16, 2023
Matrix-assisted laser desorption and ionization (MALDI) is a widely used soft-ionization technique of modern mass spectrometry (MS). MALDI enables the analysis nearly all chemical compounds—including polar apolar (phospho)lipids—with minimum extent fragmentation. has some particular advantages (such as possibility to acquire spatially-resolved spectra) competitive with simultaneously developed ESI (electrospray ionization) MS. Although there are still methodological aspects that need be elucidated in more detail, it obvious careful selection an appropriate matrix plays most important role (lipid) analysis. Some lipid classes can detected exclusively if optimum used, determines sensitivity by which within mixture. Since is, thus, crucial for results, we provide here update on progress field since our original review this journal 2018. Thus, only development during last five years considered, lipids sorted according increasing complexity, starting free fatty acids ending cardiolipins phosphoinositides.
Язык: Английский
Процитировано
22
TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 170, С. 117412 - 117412
Опубликована: Ноя. 7, 2023
Язык: Английский
Процитировано
17
ACS Nano, Год журнала: 2024, Номер 18(32), С. 21336 - 21346
Опубликована: Авг. 1, 2024
Thyroid nodules (TNs) have emerged as the most prevalent endocrine disorder in China. Fine-needle aspiration (FNA) remains standard diagnostic method for assessing TN malignancy, although a majority of FNA results indicate benign conditions. Balancing accuracy while mitigating overdiagnosis patients with poses significant clinical challenge. Precise, noninvasive, and high-throughput screening methods high-risk diagnosis are highly desired but remain less explored. Developing such approaches can improve noninvasive like ultrasound imaging reduce nodule caused by invasive procedures. Herein, we investigate application gold-doped zirconium-based metal-organic framework (ZrMOF/Au) nanostructures metabolic profiling thyroid diseases. This approach enables efficient extraction urine metabolite fingerprints high throughput, low background noise, reproducibility. Utilizing partial least-squares discriminant analysis four machine learning models, including neural network (NN), random forest (RF), logistic regression (LR), support vector (SVM), achieved an enhanced (98.6%) discriminating cancer (TC) from low-risk TNs using panel. Through differences, potential pathway changes between malignancy identified. work explores rapid disease ZrMOF/Au-assisted LDI-MS platform, providing malignant tumors. Integrating this technologies enhance reliability tumor screening, helping to prevent unnecessary procedures reducing risk overtreatment nodules.
Язык: Английский
Процитировано
7
International Journal of Mass Spectrometry, Год журнала: 2024, Номер 498, С. 117219 - 117219
Опубликована: Фев. 20, 2024
Язык: Английский
Процитировано
5
Chemical Engineering Journal, Год журнала: 2022, Номер 454, С. 139978 - 139978
Опубликована: Окт. 26, 2022
Язык: Английский
Процитировано
20
Analytical and Bioanalytical Chemistry, Год журнала: 2023, Номер 415(18), С. 4125 - 4145
Опубликована: Июнь 17, 2023
Язык: Английский
Процитировано
12