Enal Transfer via Piano-Stool Rh-Enalcarbenoids: Rapid Construction of Enal-Functionalized Isoquinolones, Application Toward Benzo[c]phenanthridinone Scaffolds DOI
Pratap Kumar Mandal, Sudhir Muduli, Sreenivas Katukojvala

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Herein, we disclosed a Rh-catalyzed site-selective enal transfer reaction of benzamides with diazoenals leading to multisubstituted enal-functionalized isoquinolone derivatives. The involves arene ortho C–H activation, migratory insertion new class N-heterocyclic Piano-stool Rh-enalcarbenoid, and metal-templated cyclization. synthetic utility isoquinolones has been demonstrated by the short synthesis valuable benzo[c]phenanthridinone scaffolds, which are present in many naturally occurring alkaloids broad pharmacological properties an analogue oxyavicine natural product used for ophthalmic disorders.

Язык: Английский

Enal Transfer via Piano-Stool Rh-Enalcarbenoids: Rapid Construction of Enal-Functionalized Isoquinolones, Application Toward Benzo[c]phenanthridinone Scaffolds DOI
Pratap Kumar Mandal, Sudhir Muduli, Sreenivas Katukojvala

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Herein, we disclosed a Rh-catalyzed site-selective enal transfer reaction of benzamides with diazoenals leading to multisubstituted enal-functionalized isoquinolone derivatives. The involves arene ortho C–H activation, migratory insertion new class N-heterocyclic Piano-stool Rh-enalcarbenoid, and metal-templated cyclization. synthetic utility isoquinolones has been demonstrated by the short synthesis valuable benzo[c]phenanthridinone scaffolds, which are present in many naturally occurring alkaloids broad pharmacological properties an analogue oxyavicine natural product used for ophthalmic disorders.

Язык: Английский

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