Enal Transfer via Piano-Stool Rh-Enalcarbenoids: Rapid Construction of Enal-Functionalized Isoquinolones, Application Toward Benzo[c]phenanthridinone Scaffolds DOI
Pratap Kumar Mandal, Sudhir Muduli, Sreenivas Katukojvala

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Herein, we disclosed a Rh-catalyzed site-selective enal transfer reaction of benzamides with diazoenals leading to multisubstituted enal-functionalized isoquinolone derivatives. The involves arene ortho C–H activation, migratory insertion new class N-heterocyclic Piano-stool Rh-enalcarbenoid, and metal-templated cyclization. synthetic utility isoquinolones has been demonstrated by the short synthesis valuable benzo[c]phenanthridinone scaffolds, which are present in many naturally occurring alkaloids broad pharmacological properties an analogue oxyavicine natural product used for ophthalmic disorders.

Language: Английский

Enal Transfer via Piano-Stool Rh-Enalcarbenoids: Rapid Construction of Enal-Functionalized Isoquinolones, Application Toward Benzo[c]phenanthridinone Scaffolds DOI
Pratap Kumar Mandal, Sudhir Muduli, Sreenivas Katukojvala

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Herein, we disclosed a Rh-catalyzed site-selective enal transfer reaction of benzamides with diazoenals leading to multisubstituted enal-functionalized isoquinolone derivatives. The involves arene ortho C–H activation, migratory insertion new class N-heterocyclic Piano-stool Rh-enalcarbenoid, and metal-templated cyclization. synthetic utility isoquinolones has been demonstrated by the short synthesis valuable benzo[c]phenanthridinone scaffolds, which are present in many naturally occurring alkaloids broad pharmacological properties an analogue oxyavicine natural product used for ophthalmic disorders.

Language: Английский

Citations

0