Clinical & Translational Oncology, Год журнала: 2025, Номер unknown
Опубликована: Май 2, 2025
Язык: Английский
APOPTOSIS, Год журнала: 2022, Номер 27(5-6), С. 297 - 310
Опубликована: Март 21, 2022
Язык: Английский
Процитировано
45
Critical Reviews in Oncology/Hematology, Год журнала: 2022, Номер 173, С. 103680 - 103680
Опубликована: Апрель 8, 2022
Язык: Английский
Процитировано
41
Current Topics in Medicinal Chemistry, Год журнала: 2023, Номер 23(12), С. 1104 - 1122
Опубликована: Фев. 1, 2023
Abstract: Tumor-associated macrophages (TAMs) play a pivotal role in the progression and re-sistance of tumors to different anticancer drugs. TAMs can modulate tumor microenvironment (TME) favor immune system exhaustion. The interactions with TME affect function cytotoxic CD8+ T lymphocytes (CTLs) natural killer (NK) cells. Furthermore, induce cancer cell proliferation by releasing some growth factors, such as transforming factor (TGF)-β. have several positive cross-talks other suppressive cells regulatory (Tregs), myeloid-derived suppressor (MDSCs), cancer-associated fibroblasts (CAFs), cells, leading release prolif-eration growth. These also invasion migration angiogenesis, metastasis. inhibition is an intriguing strategy for overcoming resistance suppression Some natural-derived agents melatonin, curcumin, resveratrol, apigenin, flavonoids shown ability TME, including TAMs. adjuvants may be able boost antitumor immunity through modulation This review explains modulatory effects well-known naturally derived on activity these useful suppressing invasion.
Язык: Английский
Процитировано
41
Clinical and Experimental Pharmacology and Physiology, Год журнала: 2023, Номер 50(5), С. 353 - 368
Опубликована: Фев. 14, 2023
Immune reactions are involved in both tumour and normal tissue response to therapy. Elevated secretion of certain chemokines, exosomes cytokines triggers inflammation, pain, fibrosis ulceration among other side effects. On the hand, tumour-promoting molecules suppresses activity anticancer immune cells facilitates proliferation malignant cells. Novel drugs such as checkpoint inhibitors (ICIs) boost immunity via inducing natural killer (NK) CD8+ T lymphocytes. Certain chemotherapy radiotherapy may induce tumour, however, have severe effects for tissues through stimulation several responses. Thus, administration products with low be a promising approach modulate system organs. Resveratrol is well-known phenol diverse on tumours. To date, large number experiments confirmed potential resveratrol an adjuvant. This review focuses ensuing or suppression responses after drugs. Later on, immunoregulatory following exposure agents will discussed.
Язык: Английский
Процитировано
29
Cancer Cell International, Год журнала: 2023, Номер 23(1)
Опубликована: Май 23, 2023
Oral cancers are among the common head and neck malignancies. Different anticancer therapy modalities such as chemotherapy, immunotherapy, radiation therapy, also targeted molecular may be prescribed for targeting oral Traditionally, it has been assumed that malignant cells alone by chemotherapy radiotherapy suppresses tumor growth. In last decade, a large number of experiments have confirmed pivotal role other secreted molecules in microenvironment (TME) on progression. Extracellular matrix immunosuppressive tumor-associated macrophages, myeloid-derived suppressor (MDSCs), cancer-associated fibroblasts (CAFs), regulatory T (Tregs) play key roles progression tumors like resistance to therapy. On hand, infiltrated CD4 + CD8 lymphocytes, natural killer (NK) anti-tumor suppress proliferation cells. Modulation extracellular cells, stimulation immunity suggested treat malignancies more effectively. Furthermore, administration some adjuvants or combination this review, we discuss various interactions between cancer TME. review basic mechanisms within TME cause Potential targets approaches overcoming will reviewed. The findings potential therapeutic clinical studies
Язык: Английский
Процитировано
26
Environmental Research, Год журнала: 2023, Номер 233, С. 116432 - 116432
Опубликована: Июнь 16, 2023
Язык: Английский
Процитировано
25
Journal of Genetic Engineering and Biotechnology, Год журнала: 2024, Номер 22(1), С. 100339 - 100339
Опубликована: Янв. 22, 2024
Breast cancer (BC) has transcended lung as the most common in world. Due to disease's aggressiveness, rapid growth, and heterogeneity, it is crucial investigate different therapeutic approaches for treatment. According World Health Organization (WHO), Plant-based therapeutics continue be utilized safe/non-toxic complementary or alternative treatments cancer, even developed countries, regardless of how cutting-edge conventional therapies are. Despite their low bioavailability, curcumin (CUR) green tea (GT) represent safer options. potent molecular-modulating properties on various cancer-related molecules signaling pathways, they are considered gold-standard agents have been incorporated into development one more strategies BC We investigated modulatory role CUR GT extracts significant multi molecular targets MCF-7 cell line assess potential multi-targeting agents. analyzed phytocompounds leaves using High-performance liquid chromatography (HPLC) Gas chromatography-mass spectrometry (GC-MS) techniques. The mRNA expression levels Raf-1, Telomerase, Tumor necrosis factor alpha (TNF-α) Interleukin-8 (IL-8) genes cells were quantified quantitative real-time PCR (qRT-PCR). cytotoxicity was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay released Lactate dehydrogenase (LDH), a valuable marker identifying programmed (necroptosis). Additionally, concentrations necroptosis-related proinflammatory cytokines (TNF-α IL-8) measured enzyme-linked immunosorbent (ELISA). In contrast GT, results showed anticancer cytotoxic against cells, with relatively higher level LDH. extract downregulated oncogenic suppressed Telomerase upregulated TNF-α IL-8 genes. Results from ELISA notable increase after treatment, which culminated 72 h. Among both extracts, only effectively modulated understudy targets, achieving activity cells. Moreover, applied dosage significantly increased cytokines, component cytokines-targeting-based strategy. However, further investigations recommended validate this approach.
Язык: Английский
Процитировано
10
International Immunopharmacology, Год журнала: 2022, Номер 108, С. 108890 - 108890
Опубликована: Май 24, 2022
Язык: Английский
Процитировано
39
Molecular and Cellular Biochemistry, Год журнала: 2022, Номер 478(1), С. 197 - 214
Опубликована: Июнь 30, 2022
Язык: Английский
Процитировано
34
Current Topics in Medicinal Chemistry, Год журнала: 2022, Номер 23(8), С. 629 - 648
Опубликована: Окт. 14, 2022
Abstract: Cancer therapy through anticancer drugs and radiotherapy is associated with several side effects as well tumor resistance to therapy. The genotoxic of chemotherapy may lead genomic instability increased risk second cancers. Furthermore, some responses in the induce exhaustion antitumor immunity increase cancer cells Administration low-toxicity adjuvants protect normal tissues improve efficacy an intriguing strategy. Several studies have focused on natural-derived agents for improving efficiency radiotherapy, chemotherapy, novel such immunotherapy targeted Resveratrol a naturally occurring substance antioxidant, cardioprotective, anti-diabetes, properties. has been demonstrated modulate mitigate tissue toxicity following exposure various ionizing radiation. Compelling data suggest that resveratrol be appealing adjuvant combination modalities. Although natural form limitations, low absorption intestine bioavailability, experiments using certain carriers, nanoparticles, can therapeutic preclinical studies. This review highlights useful Consequently, we describe how from instability. In addition, mechanisms by which exerts its are addressed. Moreover, outcomes other reviewed.
Язык: Английский
Процитировано
33