Nanozyme‐Enhanced Electrochemical Biosensors: Mechanisms and Applications

Small, Год журнала: 2023, Номер 20(14)

Опубликована: Ноя. 20, 2023

Abstract Nanozymes, as innovative materials, have demonstrated remarkable potential in the field of electrochemical biosensors. This article provides an overview mechanisms and extensive practical applications nanozymes First, definition characteristics are introduced, emphasizing their significant role constructing efficient sensors. Subsequently, several common categories nanozyme materials delved into, including metal‐based, carbon‐based, metal‐organic framework, layered double hydroxide nanostructures, discussing Regarding mechanisms, two key roles particularly focused biosensors: selective enhancement signal amplification, which crucially support sensor performance. In terms applications, widespread use nanozyme‐based biosensors showcased various domains. From detecting biomolecules, pollutants, nucleic acids, proteins, to cells, providing robust means for high‐sensitivity detection. Furthermore, insights into future development is provided, encompassing improvements optimizations design integration, expansion application fields through interdisciplinary collaboration. conclusion, this systematically presents biosensors, offering valuable references prospects research field.

Язык: Английский

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Recent advances in multi‐metallic‐based nanozymes for enhanced catalytic cancer therapy

BMEMat, Год журнала: 2023, Номер unknown

Опубликована: Сен. 19, 2023

Abstract Nanozymes have emerged as a promising alternative to natural enzymes, effectively addressing enzymes' inherent limitation. Versatility and potential applications of nanozyme span across various fields, with catalytic tumor therapy being one prominent area. This has sparked significant interest exploration in the utilization nanozymes for targeted cancer treatment. Recent advancements interdisciplinary research, nanotechnology, biotechnology, technology led emergence multi‐metallic‐based nanozymes, which exhibit tremendous further development. review focuses on investigating synergistic effects aiming enhance our understanding their activities facilitate broader applications. We comprehensively survey remarkable achievements synthesis, mechanisms, latest therapy. Furthermore, we identify current limitations prospects development new materials application novel technologies, along challenges associated underscores significance emphasizes need continued well impact realization breakthroughs

Язык: Английский

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Self‐Reinforced Bimetallic Mito‐Jammer for Ca²⁺ Overload‐Mediated Cascade Mitochondrial Damage for Cancer Cuproptosis Sensitization

Advanced Science, Год журнала: 2024, Номер 11(15)

Опубликована: Фев. 11, 2024

Abstract Overproduction of reactive oxygen species (ROS), metal ion accumulation, and tricarboxylic acid cycle collapse are crucial factors in mitochondria‐mediated cell death. However, the highly adaptive nature damage‐repair capabilities malignant tumors strongly limit efficacy treatments based on a single treatment mode. To address this challenge, self‐reinforced bimetallic Mito‐Jammer is developed by incorporating doxorubicin (DOX) calcium peroxide (CaO 2 ) into hyaluronic (HA) ‐modified metal‐organic frameworks (MOF). After cellular, dissociates CaO Cu 2+ tumor microenvironment. The exposed further yields hydrogen (H O Ca weakly acidic environment to strengthen ‐based Fenton‐like reaction. Furthermore, combination chemodynamic therapy overload exacerbates ROS storms mitochondrial damage, resulting downregulation intracellular adenosine triphosphate (ATP) levels blocking Cu‐ATPase sensitize cuproptosis. This multilevel interaction strategy also activates robust immunogenic death suppresses metastasis simultaneously. study presents multivariate model for revolutionizing mitochondria relying continuous retention ions boost cuproptosis/immunotherapy cancer.

Язык: Английский

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NIR-enhanced Pt single atom/g-C3N4 nanozymes as SOD/CAT mimics to rescue ATP energy crisis by regulating oxidative phosphorylation pathway for delaying osteoarthritis progression

Bioactive Materials, Год журнала: 2024, Номер 36, С. 1 - 13

Опубликована: Фев. 21, 2024

Osteoarthritis (OA) progresses due to the excessive generation of reactive oxygen and nitrogen species (ROS/RNS) abnormal ATP energy metabolism related oxidative phosphorylation pathway in mitochondria. Highly active single-atom nanozymes (SAzymes) can help regulate redox balance have shown their potential treatment inflammatory diseases. In this study, we innovatively utilised ligand-mediated strategies chelate Pt

Язык: Английский

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Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Advanced Functional Materials, Год журнала: 2024, Номер 34(23)

Опубликована: Янв. 7, 2024

Abstract The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized play an important role in homeostasis regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes holds promise as external intervention enhance synthesis extracellular matrix, thereby accelerating Hence, electroactive biomaterials considered a biomimetic approach ensure functional recovery integrating physiological signals, including electrical, biochemical, mechanical signals. This review will discuss endogenous bioelectricity tissue, effects ES on cellular behaviors. Then, recent advances materials their applications are systematically overviewed, with focus advantages disadvantages repair performances modulation cell fate. Finally, significance mimicking electrophysiological microenvironment target emphasized future development challenges strategies proposed.

Язык: Английский

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Quantifying Dielectric Material Charge Trapping and De‐Trapping Ability Via Ultra‐Fast Charge Self‐Injection Technique

Advanced Materials, Год журнала: 2024, Номер 36(19)

Опубликована: Фев. 7, 2024

Recently, utilizing the air breakdown effect in charge excitation strategy proves as an efficient injection technique to increase surface density of dielectric polymers for triboelectric nanogenerators (TENGs). However, quantitative characterization ability trap reverse charges and on startup time secondary self-charge (SSCE) are essential extensive applications. Here, ultra-fast self-injection based a is proposed, standard method quantify trapping de-trapping abilities 23 traditional tribo-materials introduced. Further, relationship among distribution intrinsic deep, shallow states, transportation trapped systematically analyzed this article. It shows that rate directly determines reactivation failure SSCE. Last, independent TENG contact efficiency, ultra-high 2.67 mC m

Язык: Английский

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Metformin-Mediated Fast Charge-Reversal Nanohybrid for Deep Penetration Piezocatalysis-Augmented Chemodynamic Immunotherapy of Cancer

ACS Nano, Год журнала: 2024, Номер 18(8), С. 6314 - 6332

Опубликована: Фев. 12, 2024

Immune checkpoint blockade (ICB) therapy still suffers from insufficient immune response and adverse effect of ICB antibodies. Chemodynamic (CDT) has been demonstrated to be an effective way synergize with therapy. However, a low generation rate reactive oxygen species poor tumor penetration CDT platforms decline the effects. Herein, charge-reversal nanohybrid Met@BF containing both Fe3O4 BaTiO3 nanoparticles in core Metformin (Met) on surface was fabricated for microenvironment (TME)- ultrasound (US)-activated piezocatalysis-chemodynamic immunotherapy cancer. Interestingly, had negative charge blood circulation, which rapidly changed into positive when exposed acidic TME attributed quaternization tertiary amine Met, facilitating deep penetration. Subsequently, US irradiation, produced H2O2 based piezocatalysis BaTiO3, greatly enhanced Fenton reaction Fe3O4, thus boosting robust antitumor response. Furthermore, PD-L1 expression inhibited by local released Met further augment effect, achieving inhibitions primary metastatic tumors. Such combination piezocatalysis-enhanced chemodynamic Met-mediated downregulation provides promising strategy cancer immunotherapy.

Язык: Английский

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Manganese Dioxide Coated Piezoelectric Nanosonosensitizer for Cancer Therapy with Tumor Microenvironment Remodeling and Multienzyme‐Like Catalysis

Small Methods, Год журнала: 2024, Номер unknown

Опубликована: Апрель 1, 2024

Abstract Sonodynamic therapy (SDT) as an emerging method for cancer has encountered difficulty in insufficient production of reactive oxygen species (ROS), especially tumor microenvironment (TME) with elevated antioxidants and hypoxic conditions. In this work, the authors have fabricated heterostructured manganese dioxide (MnO 2 )‐coated BaTiO 3 nanoparticles (BTO@M NPs) a piezoelectric sonosensitizer, which exhibits capacity remodeling TME multienzyme‐like catalysis boosting SDT. Benefitting from piezotronic effect, formation p ‐ n junction between MnO BTO built‐in electric field band bending efficiently promotes separation charge carriers, facilitating generation superoxide anion (•O − ) hydroxyl radical (•OH) under ultrasound (US) stimulation. Moreover, BTO@M NPs can catalyze overexpressed hydrogen peroxide (H O to produce replenishing gas source SDT, also deplete antioxidant glutathione (GSH), realizing remodeling. During process, reduced Mn(II) convert H into •OH, further amplifying cellular oxidative damage. With these combination effects, versatile exhibit prominent cytotoxicity growth inhibition against 4T1 breast cancer. This work provides feasible strategy constructing high‐efficiency sonosensitizers

Язык: Английский

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Conductive Dual-Network Hydrogel-Based Multifunctional Triboelectric Nanogenerator for Temperature and Pressure Distribution Sensing

Nano Energy, Год журнала: 2024, Номер 127, С. 109772 - 109772

Опубликована: Май 20, 2024

Язык: Английский

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Decoding the “Fingerprint” of Implant Materials: Insights into the Foreign Body Reaction

Small, Год журнала: 2024, Номер 20(23)

Опубликована: Янв. 8, 2024

Abstract Foreign body reaction (FBR) is a prevalent yet often overlooked pathological phenomenon, particularly within the field of biomedical implantation. The presence FBR poses heavy burden on both medical and socioeconomic systems. This review seeks to elucidate protein “fingerprint” implant materials, which generated by physiochemical properties materials themselves. In this review, activity macrophages, formation foreign giant cells (FBGCs), development fibrosis capsules in context are introduced. Additionally, relationship between various elucidated detail, as an overview existing approaches technologies employed alleviate FBR. Finally, significance components (metallic non‐metallic materials), surface CHEMISTRY (charge wettability), physical characteristics (topography, roughness, stiffness) establishing also well documented. conclusion, aims emphasize importance provides current perspectives developing with anti‐FBR properties.

Язык: Английский

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