Metformin-based nanomedicines for reprogramming tumor immune microenvironment

Theranostics, Год журнала: 2024, Номер 15(3), С. 993 - 1016

Опубликована: Дек. 2, 2024

Immunotherapy has transformed current cancer management, and it achieved significant progress over last decades. However, an immunosuppressive tumor microenvironment (TME) diminishes the effectiveness of immunotherapy by suppressing activity immune cells facilitating immune-evasion. Adenosine monophosphate-activated protein kinase (AMPK), a key modulator cellular energy metabolism homeostasis, gained growing attention in anti-tumor immunity. Metformin is usually considered as cornerstone diabetes its role activating AMPK pathway also been extensively explored therapy although findings on remain inconsistent. nanomedicine formulation found to hold potential reprogramming TME through immunometabolic modulation both cells. This review elaborates foundation via metformin-based nanomedicines, offering valuable insights for next generation therapy.

Язык: Английский

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Black Phosphorus Quantum Dot Loaded Bioinspired Nanoplatform Synergized with aPD-L1 for Multimode Cancer Immunotherapy

Nano Letters, Год журнала: 2024, Номер 24(22), С. 6767 - 6777

Опубликована: Май 21, 2024

Efforts to prolong the blood circulation time and bypass immune clearance play vital roles in improving therapeutic efficacy of nanoparticles (NPs). Herein, a multifunctional nanoplatform (BPP@RTL) that precisely targets tumor cells is fabricated by encapsulating ultrasmall phototherapeutic agent black phosphorus quantum dot (BPQD), chemotherapeutic drug paclitaxel (PTX), immunomodulator PolyMetformin (PM) hybrid membrane-camouflaged liposomes. Specifically, cell membrane coating derived from fusion cancer red displays excellent targeting efficiency long property due innate features both membranes. After collaboration with aPD-L1-based checkpoint blockade therapy, boosted immunotherapeutic effect obtained elevated dendritic maturation T activation. Significantly, laser-irradiated BPP@RTL combined aPD-L1 effectively eliminates primary tumors inhibits lung metastasis 4T1 breast model, offering promising treatment plan develop personalized antitumor strategy.

Язык: Английский

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Steering Piezocatalytic Therapy for Optimized Tumoricidal Effect

Advanced Functional Materials, Год журнала: 2024, Номер 34(33)

Опубликована: Май 16, 2024

Abstract Piezocatalysts, because of their mechano‐electrical conversion properties, are exploited for various medical applications, such as sterilization, tissue engineering, biosensing, and disease theranostics. In particular, based on the unique advantage piezoelectric effect, piezocatalytic therapy (PCT) has been developed a novel promising candidate tumor therapy. To optimize utilization piezocatalysts in therapy, comprehensive understanding antitumor mechanism associated with these materials is imperative. Here, action principle elucidated by investigating piezocatalysts, reactants, energy inputs, products. Subsequently, mechanisms PCT have extensively discussed recapitulative follows: restraining cell proliferation, inducing programmed death, hindering metastasis, inhibiting angiogenesis, enhancing immunity. Additionally, optimized therapeutic outcomes PCT‐centric synergistic cancer systematically described. Finally, main challenges future research directions piezocatalysis applied envisioned. It believed that will serve new‐generation ingenious tool treatment.

Язык: Английский

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Reprogramming Dysfunctional Dendritic Cells by a Versatile Catalytic Dual Oxide Antigen-Captured Nanosponge for Remotely Enhancing Lung Metastasis Immunotherapy

ACS Nano, Год журнала: 2024, Номер unknown

Опубликована: Дек. 31, 2024

Dendritic cells (DCs) play a crucial role in initiating antitumor immune responses. However, the tumor environment, dendritic often exhibit impaired antigen presentation and adopt an immunosuppressive phenotype, which hinders their function reduces ability to efficiently present antigens. Here, dual catalytic oxide nanosponge (DON) doubling as remotely boosted catalyst inducer of programming DCs program therapy is reported. Intravenous delivery DON enhances accumulation via marginated target. At site, incorporates cerium nanozyme (CeO

Язык: Английский

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Advances in Multimodal Synergistic Therapy Derived from Sonodynamic Therapy Mediated by BaTiO₃ Piezoelectric Nanomaterials in Tumor Treatment

Small Structures, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Tumors endanger the lives of individuals worldwide. They form and metastatize to nearby distant tissues organs in several ways, which greatly increase difficulty therapy. The continuous development progress nanomedicine has provided new insights treatment tumors. Owing their excellent properties barium titanate (BaTiO 3 , BTO), especially piezoelectricity, BTO‐based nanomaterials have become popular among tumor therapy researchers recent years. sonodynamic (SDT) is considerably advanced than traditional therapies. Herein, first, properties, structure, preparation technology, working mechanism BTO under ultrasonic stimulation systematically introduced. Second, research BTO‐mediated SDT, electrical therapy, SDT‐derived multimodal synergistic field reviewed. Third, biocompatibility, biodistribution, bioelimination summarized. Finally, current problems associated with SDT as well potential obstacles opportunities oncology other biomedical fields are summarized prospected.

Язык: Английский

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Hyperthermia-Accelerated Ion-Radical Production for Enhanced Tumor Nanocatalytic Therapy with Inhibition of Tumor Growth and Recurrence

Опубликована: Янв. 1, 2025

Язык: Английский

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Emerging Piezoelectric Sonosensitizer for ROS-Driven Sonodynamic Cancer Therapy

Inorganics, Год журнала: 2025, Номер 13(3), С. 71 - 71

Опубликована: Фев. 26, 2025

As a non-invasive modality, sonodynamic therapy (SDT) offers several advantages in cancer treatment, including deep tissue penetration and precise spatiotemporal control, resulting from the interplay between low-intensity ultrasound sonosensitizers. Piezoelectric materials, known for their remarkable capacity of interconversion mechanical electrical energy, have garnered considerable attention biomedical applications, which can serve as pivotal sonosensitizers SDT. These materials generate internal electric fields via ultrasound-induced deformation, modulates alteration charge carriers, thereby initiating surface redox reactions to reactive oxygen species (ROS) realizing therapeutic efficacy This review provides an in-depth exploration piezoelectric utilized SDT, with particular emphasis on recent innovations, elucidation underlying mechanisms, optimization strategies advanced materials. Furthermore, incorporation immunotherapy, photodynamic, chemodynamic, chemotherapy is explored, emphasizing potential enhance outcomes. By examining basic principles effect its contributions this sheds light promising applications oncology. It also highlights future directions improving these expanding clinical utility tumor therapy.

Язык: Английский

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Heterogeneous Piezo-self-Fenton material design: intersecting solution for pollutant degradation and tumor therapy

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The commonalities and differences of EPSF catalysts in organic pollutant degradation tumor-targeted therapy are summarized, focusing on catalytic mechanisms, material systems, performance enhancement strategies, catalyst design.

Язык: Английский

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Calcium peroxide functionalized mesoporous polydopamine nanoparticles triggered calcium overload for synergistic tumor gas/photothermal therapy

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 690, С. 137332 - 137332

Опубликована: Март 14, 2025

Язык: Английский

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Matrix-degrading soft-nanoplatform with enhanced tissue penetration for amplifying photodynamic therapeutic efficacy of breast cancer

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(32), С. 7837 - 7847

Опубликована: Янв. 1, 2024

The dense extracellular matrix (ECM) in the tumor microenvironment forms an abnormal physical barrier, which impedes delivery and penetration of nanomedicines hinders their therapeutic efficacy. Herein, we synthesize matrix-degrading soft-nanocapsules composed human serum albumin (HSA) hyaluronidase (HAase) for overcoming obstruction ECM microenvironment. albumin/hyaluronidase soft-nanocapsules, referred to as HSA/HAase SNCs, possess a uniform diameter, inward hollow structure, wrinkled morphology.

Язык: Английский

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