Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2023, Номер 672, С. 131763 - 131763
Опубликована: Май 30, 2023
Язык: Английский
Materials Today Bio, Год журнала: 2023, Номер 21, С. 100710 - 100710
Опубликована: Июнь 25, 2023
Electrospinning as a versatile, simple, and cost-effective method to engineer variety of micro or nanofibrous materials, has contributed significant developments in the biomedical field. However, traditional electrospinning single material only can produce homogeneous fibrous assemblies with limited functional properties, which oftentimes fails meet ever-increasing requirements applications. Thus, multi-material referring engineering two more kinds been recently developed enable fabrication diversified complex structures advanced performance for greatly promoting development. This review firstly gives an overview modalities, highlight on their features accessibility constructing different structures. A perspective how opens up new opportunities specific applications, i.e., tissue drug delivery, is also offered.
Язык: Английский
Процитировано
72
ACS Nano, Год журнала: 2024, Номер 18(8), С. 6038 - 6094
Опубликована: Фев. 13, 2024
Two-dimensional (2D) materials have attracted tremendous interest ever since the isolation of atomically thin sheets graphene in 2004 due to specific and versatile properties these materials. However, increasing production use 2D necessitate a thorough evaluation potential impact on human health environment. Furthermore, harmonized test protocols are needed with which assess safety The Graphene Flagship project (2013-2023), funded by European Commission, addressed identification possible hazard graphene-based as well emerging including transition metal dichalcogenides, hexagonal boron nitride, others. Additionally, so-called green chemistry approaches were explored achieve goal safe sustainable this fascinating family nanomaterials. present review provides compact survey findings lessons learned Flagship.
Язык: Английский
Процитировано
31
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Май 31, 2024
Myocardial infarction (MI) stands as a prominent contributor to global cardiovascular disease (CVD) mortality rates. Acute MI (AMI) can result in the loss of large number cardiomyocytes (CMs), which adult heart struggles replenish due its limited regenerative capacity. Consequently, this deficit CMs often precipitates severe complications such failure (HF), with whole transplantation remaining sole definitive treatment option, albeit constrained by inherent limitations. In response these challenges, integration bio-functional materials within cardiac tissue engineering has emerged groundbreaking approach significant potential for replacement. Bioengineering strategies entail fortifying or substituting biological tissues through orchestrated interplay cells, methodologies, and innovative materials. Biomaterial scaffolds, crucial paradigm, provide essential microenvironment conducive assembly functional encapsulating contracting cells. Indeed, field witnessed remarkable strides, largely owing application biomaterial scaffolds. However, complexities persist, necessitating further exploration innovation. This review delves into pivotal role scaffolds engineering, shedding light on their utilization, challenges encountered, promising avenues future advancement. By critically examining current landscape, we aim catalyze progress toward more effective solutions regeneration ultimately, improved outcomes patients grappling ailments.
Язык: Английский
Процитировано
25
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160852 - 160852
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
4
Journal of Biomedical Materials Research Part A, Год журнала: 2025, Номер 113(1)
Опубликована: Янв. 1, 2025
ABSTRACT In the human body, bioelectric cues are crucial for tissue stimulation and regeneration. Electrical (ES) significantly enhances regeneration of nerves, bones, cardiovascular tissues, wounds. However, use conventional devices with stimulating metal electrodes is invasive requires external batteries. Consequently, electrically active materials excellent biocompatibility have attracted attention their applications in engineering. To fully exploit potential these materials, biocompatibility, operating mechanisms, electrical properties, even biodegradability should be carefully considered. this review, we categorize various biomaterials based on mechanisms generating cues, such as piezoelectric effect, triboelectric others. We also summarize key material including characteristics biodegradability, describe musculoskeletal tissues. The hold great advancing field engineering demonstrated success underscores importance continued research field.
Язык: Английский
Процитировано
3
Bioengineering & Translational Medicine, Год журнала: 2022, Номер 8(1)
Опубликована: Май 28, 2022
Abstract A proper self‐regenerating capability is lacking in human cardiac tissue which along with the alarming rate of deaths associated cardiovascular disorders makes engineering critical. Novel approaches are now being investigated order to speedily overcome challenges this path. Tissue has been revolutionized by advent nanomaterials, and later application carbon‐based nanomaterials because their exceptional variable functionality, conductivity, mechanical properties. Electrically conductive biomaterials used as cell bearers provide an appropriate microenvironment for specific seeded cells substrates sake protecting biological media against attacking mechanisms. Nevertheless, advantages shortcoming view cellular behavior, toxicity, targeted delivery depend on they implanted or a scaffold. This review seeks address, summarize, classify, conceptualize, discuss use nanoparticles emphasizing conductivity. We considered electrical conductivity key affecting regeneration cells. Correspondingly, we reviewed polymers specifically repair high efficiency. comprehensively classified discussed using engineering. An overall open literature electroactive including over last decade was provided, tabulated, thoroughly discussed. The most commonly comprising graphene, graphene oxide, carbon nanotubes, nanofibers were studied.
Язык: Английский
Процитировано
71
Advances in Colloid and Interface Science, Год журнала: 2022, Номер 308, С. 102771 - 102771
Опубликована: Сен. 7, 2022
Язык: Английский
Процитировано
49
Polymer Engineering and Science, Год журнала: 2022, Номер 62(9), С. 2741 - 2749
Опубликована: Июль 1, 2022
Abstract Silk fibroin (SF) has been broadly applied in wound dressing fabrication because of its proper features for healing. In this work, we developed a carboxymethyl cellulose (CMC)/gelatin blend film with different concentrations glycerol, and modified the optimized an SF layer through electrospinning process. Tensile strength cell viability evaluation films demonstrated that glycerol content 3% could be suitable as substrate two‐layer dressing. The morphology electrospun nanofibers was obtained from scanning electron microscopy (SEM) Fourier transform infrared spectroscopy (FTIR). It concluded structural changes had occurred both layers after cross‐linking glutaraldehyde vapor. Further, it shown mechanical properties enhanced addition SF. Moreover, swelling ratio higher than those itself, due to hydrophilic property CMC/gelatin film. biocompatibility fibroblasts investigated by MTT assay, coating showed improvement proliferation cytocompatibility nature All results suggest prepared desirable candidate healing applications.
Язык: Английский
Процитировано
47
Alexandria Engineering Journal, Год журнала: 2023, Номер 81, С. 137 - 169
Опубликована: Сен. 14, 2023
The advancement of tissue engineering for regenerating injured tissues and organs has progressed significantly in recent years. Various techniques have been used to modify the cells' microenvironments targeted via their extracellular environment achieving these aims. 3D structured scaffolds alone or combined with bioactive molecules genes cells hold great promise development functional engineered tissues. As an emerging state-of-the-art technology this field, integrating gene therapy, known as gene-activated matrix (GAM), gained immense attention a promising approach restoring damaged dysfunctional tissues' function structure. Nonetheless, fabricating GAMs low cytotoxicity, high transfection efficiency, long-term delivery efficiency is still challenging. Here we provide complete overview different approaches ongoing preclinical research trials. Moreover, GAM strategy focus on development, faithful application, future prospects repair regeneration replacement assayed. challenges regenerative medicine are also presented. Eventually, propose that offer basic mechanistic infrastructure "tissue engineering" pave way clinical translation achieve personalized medicine.
Язык: Английский
Процитировано
37
ACS Omega, Год журнала: 2023, Номер 8(24), С. 22178 - 22189
Опубликована: Июнь 6, 2023
Green-emissive carbon quantum dots (CQDs) with exclusive chemosensing aspects were synthesized from orange pomace as a biomass-based precursor via facile microwave method without using any chemicals. The synthesis of highly fluorescent CQDs inherent nitrogen was confirmed through X-ray diffraction, photoelectron, Fourier transform infrared, Raman, and transmission electron microscopic techniques. average size the found to be 7.5 nm. These fabricated displayed excellent photostability, water solubility, outstanding yield, i.e., 54.26%. showed promising results for detection Cr6+ ions 4-nitrophenol (4-NP). sensitivity toward 4-NP up nanomolar range limit values 59.6 14 nM, respectively. Several analytical performances thoroughly studied high precision dual analytes proposed nanosensor. Various photophysical parameters (quenching efficiency, binding constant, etc.) analyzed in presence gain more insights into sensing mechanism. exhibited fluorescence quenching incrementing quencher concentration, which rationalized by inner filter effect time-correlated single-photon counting measurements. current work lower wide linear simple, eco-friendly, rapid ions. To evaluate feasibility approach, real sample analysis conducted, demonstrating satisfactory recovery rates relative standard deviations developed probes. This research paves way developing superior characteristics utilizing (biowaste precursor).
Язык: Английский
Процитировано
27