Multi-material electrospinning: from methods to biomedical applications

Materials Today Bio, Journal Year: 2023, Volume and Issue: 21, P. 100710 - 100710

Published: June 25, 2023

Electrospinning as a versatile, simple, and cost-effective method to engineer variety of micro or nanofibrous materials, has contributed significant developments in the biomedical field. However, traditional electrospinning single material only can produce homogeneous fibrous assemblies with limited functional properties, which oftentimes fails meet ever-increasing requirements applications. Thus, multi-material referring engineering two more kinds been recently developed enable fabrication diversified complex structures advanced performance for greatly promoting development. This review firstly gives an overview modalities, highlight on their features accessibility constructing different structures. A perspective how opens up new opportunities specific applications, i.e., tissue drug delivery, is also offered.

Language: Английский

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Environmental and Health Impacts of Graphene and Other Two-Dimensional Materials: A Graphene Flagship Perspective

ACS Nano, Journal Year: 2024, Volume and Issue: 18(8), P. 6038 - 6094

Published: Feb. 13, 2024

Two-dimensional (2D) materials have attracted tremendous interest ever since the isolation of atomically thin sheets graphene in 2004 due to specific and versatile properties these materials. However, increasing production use 2D necessitate a thorough evaluation potential impact on human health environment. Furthermore, harmonized test protocols are needed with which assess safety The Graphene Flagship project (2013-2023), funded by European Commission, addressed identification possible hazard graphene-based as well emerging including transition metal dichalcogenides, hexagonal boron nitride, others. Additionally, so-called green chemistry approaches were explored achieve goal safe sustainable this fascinating family nanomaterials. present review provides compact survey findings lessons learned Flagship.

Language: Английский

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Advancements in tissue engineering for cardiovascular health: a biomedical engineering perspective

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: May 31, 2024

Myocardial infarction (MI) stands as a prominent contributor to global cardiovascular disease (CVD) mortality rates. Acute MI (AMI) can result in the loss of large number cardiomyocytes (CMs), which adult heart struggles replenish due its limited regenerative capacity. Consequently, this deficit CMs often precipitates severe complications such failure (HF), with whole transplantation remaining sole definitive treatment option, albeit constrained by inherent limitations. In response these challenges, integration bio-functional materials within cardiac tissue engineering has emerged groundbreaking approach significant potential for replacement. Bioengineering strategies entail fortifying or substituting biological tissues through orchestrated interplay cells, methodologies, and innovative materials. Biomaterial scaffolds, crucial paradigm, provide essential microenvironment conducive assembly functional encapsulating contracting cells. Indeed, field witnessed remarkable strides, largely owing application biomaterial scaffolds. However, complexities persist, necessitating further exploration innovation. This review delves into pivotal role scaffolds engineering, shedding light on their utilization, challenges encountered, promising avenues future advancement. By critically examining current landscape, we aim catalyze progress toward more effective solutions regeneration ultimately, improved outcomes patients grappling ailments.

Language: Английский

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Electrically Active Biomaterials for Stimulation and Regeneration in Tissue Engineering

Journal of Biomedical Materials Research Part A, Journal Year: 2025, Volume and Issue: 113(1)

Published: Jan. 1, 2025

ABSTRACT In the human body, bioelectric cues are crucial for tissue stimulation and regeneration. Electrical (ES) significantly enhances regeneration of nerves, bones, cardiovascular tissues, wounds. However, use conventional devices with stimulating metal electrodes is invasive requires external batteries. Consequently, electrically active materials excellent biocompatibility have attracted attention their applications in engineering. To fully exploit potential these materials, biocompatibility, operating mechanisms, electrical properties, even biodegradability should be carefully considered. this review, we categorize various biomaterials based on mechanisms generating cues, such as piezoelectric effect, triboelectric others. We also summarize key material including characteristics biodegradability, describe musculoskeletal tissues. The hold great advancing field engineering demonstrated success underscores importance continued research field.

Language: Английский

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Electrically conductive carbon‐based (bio)‐nanomaterials for cardiac tissue engineering

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(1)

Published: May 28, 2022

Abstract A proper self‐regenerating capability is lacking in human cardiac tissue which along with the alarming rate of deaths associated cardiovascular disorders makes engineering critical. Novel approaches are now being investigated order to speedily overcome challenges this path. Tissue has been revolutionized by advent nanomaterials, and later application carbon‐based nanomaterials because their exceptional variable functionality, conductivity, mechanical properties. Electrically conductive biomaterials used as cell bearers provide an appropriate microenvironment for specific seeded cells substrates sake protecting biological media against attacking mechanisms. Nevertheless, advantages shortcoming view cellular behavior, toxicity, targeted delivery depend on they implanted or a scaffold. This review seeks address, summarize, classify, conceptualize, discuss use nanoparticles emphasizing conductivity. We considered electrical conductivity key affecting regeneration cells. Correspondingly, we reviewed polymers specifically repair high efficiency. comprehensively classified discussed using engineering. An overall open literature electroactive including over last decade was provided, tabulated, thoroughly discussed. The most commonly comprising graphene, graphene oxide, carbon nanotubes, nanofibers were studied.

Language: Английский

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Magnetic nanocomposites for biomedical applications

Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 308, P. 102771 - 102771

Published: Sept. 7, 2022

Language: Английский

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Design, preparation, and characterization of silk fibroin/carboxymethyl cellulose wound dressing for skin tissue regeneration applications

Polymer Engineering and Science, Journal Year: 2022, Volume and Issue: 62(9), P. 2741 - 2749

Published: July 1, 2022

Abstract Silk fibroin (SF) has been broadly applied in wound dressing fabrication because of its proper features for healing. In this work, we developed a carboxymethyl cellulose (CMC)/gelatin blend film with different concentrations glycerol, and modified the optimized an SF layer through electrospinning process. Tensile strength cell viability evaluation films demonstrated that glycerol content 3% could be suitable as substrate two‐layer dressing. The morphology electrospun nanofibers was obtained from scanning electron microscopy (SEM) Fourier transform infrared spectroscopy (FTIR). It concluded structural changes had occurred both layers after cross‐linking glutaraldehyde vapor. Further, it shown mechanical properties enhanced addition SF. Moreover, swelling ratio higher than those itself, due to hydrophilic property CMC/gelatin film. biocompatibility fibroblasts investigated by MTT assay, coating showed improvement proliferation cytocompatibility nature All results suggest prepared desirable candidate healing applications.

Language: Английский

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Exploring the evolution of tissue engineering strategies over the past decade: From cell-based strategies to gene-activated matrix

Alexandria Engineering Journal, Journal Year: 2023, Volume and Issue: 81, P. 137 - 169

Published: Sept. 14, 2023

The advancement of tissue engineering for regenerating injured tissues and organs has progressed significantly in recent years. Various techniques have been used to modify the cells' microenvironments targeted via their extracellular environment achieving these aims. 3D structured scaffolds alone or combined with bioactive molecules genes cells hold great promise development functional engineered tissues. As an emerging state-of-the-art technology this field, integrating gene therapy, known as gene-activated matrix (GAM), gained immense attention a promising approach restoring damaged dysfunctional tissues' function structure. Nonetheless, fabricating GAMs low cytotoxicity, high transfection efficiency, long-term delivery efficiency is still challenging. Here we provide complete overview different approaches ongoing preclinical research trials. Moreover, GAM strategy focus on development, faithful application, future prospects repair regeneration replacement assayed. challenges regenerative medicine are also presented. Eventually, propose that offer basic mechanistic infrastructure "tissue engineering" pave way clinical translation achieve personalized medicine.

Language: Английский

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Electroactive biomaterials synergizing with electrostimulation for cardiac tissue regeneration and function-monitoring

Materials Today, Journal Year: 2023, Volume and Issue: 70, P. 237 - 272

Published: Sept. 30, 2023

Cardiac cells are assembled within a complicated microenvironment possessing diverse biochemical and biophysical cues that modulate cellular behaviors tissue functions. Apart from the widely studied pathways of regulation, positive effects electrical on regeneration excitable cardiac tissues have been demonstrated. Conductive biomaterials emerged as important two-way media to facilitate transmission endogenous bioelectricity or exogenous stimuli strengthening regeneration, while in meantime allow online monitoring bioelectrical activities. Mechanical energy exists prevalently heart, which brings huge promise building self-powered, enabled, on-demand stimulation system by using piezoelectric biomaterials. In this regard, conductive synergizing with electrostimulation for function-monitoring engineering comprehensively reviewed. After biological conduction human heart is firstly introduced, electroactive display biomimetic microenvironmental (e.g., electrical, mechanical, topological) their mediated summarized. Subsequently, current state systematically overviewed together underlying mechanisms modulating cell Furthermore, recent advances used function discussed. Finally, remaining challenges 3D complex designs, systematic parameter optimizations mechanisms, long-term performance, biosafety laid out, call interdisplinary joint forces innovation advancement.

Language: Английский

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Orange Pomace-Derived Fluorescent Carbon Quantum Dots: Detection of Dual Analytes in the Nanomolar Range

ACS Omega, Journal Year: 2023, Volume and Issue: 8(24), P. 22178 - 22189

Published: June 6, 2023

Green-emissive carbon quantum dots (CQDs) with exclusive chemosensing aspects were synthesized from orange pomace as a biomass-based precursor via facile microwave method without using any chemicals. The synthesis of highly fluorescent CQDs inherent nitrogen was confirmed through X-ray diffraction, photoelectron, Fourier transform infrared, Raman, and transmission electron microscopic techniques. average size the found to be 7.5 nm. These fabricated displayed excellent photostability, water solubility, outstanding yield, i.e., 54.26%. showed promising results for detection Cr6+ ions 4-nitrophenol (4-NP). sensitivity toward 4-NP up nanomolar range limit values 59.6 14 nM, respectively. Several analytical performances thoroughly studied high precision dual analytes proposed nanosensor. Various photophysical parameters (quenching efficiency, binding constant, etc.) analyzed in presence gain more insights into sensing mechanism. exhibited fluorescence quenching incrementing quencher concentration, which rationalized by inner filter effect time-correlated single-photon counting measurements. current work lower wide linear simple, eco-friendly, rapid ions. To evaluate feasibility approach, real sample analysis conducted, demonstrating satisfactory recovery rates relative standard deviations developed probes. This research paves way developing superior characteristics utilizing (biowaste precursor).

Language: Английский

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