Oral squamous cell carcinomas: state of the field and emerging directions

International Journal of Oral Science, Год журнала: 2023, Номер 15(1)

Опубликована: Сен. 22, 2023

Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of oral cavity. It accounts for approximately 90% malignancies and impairs appearance, pronunciation, swallowing, flavor perception. In 2020, 377,713 OSCC cases were reported globally. According to Global Cancer Observatory (GCO), incidence will rise by 40% 2040, accompanied a growth in mortality. Persistent exposure various risk factors, including tobacco, alcohol, betel quid (BQ), human papillomavirus (HPV), lead development potentially malignant disorders (OPMDs), which are lesions with an increased developing into OSCC. Complex multifactorial, oncogenesis process involves genetic alteration, epigenetic modification, dysregulated tumor microenvironment. Although therapeutic interventions, such as chemotherapy, radiation, immunotherapy, nanomedicine, have been proposed prevent or treat OPMDs, understanding mechanism facilitate identification prognostic thereby improving efficacy treatment patients. This review summarizes mechanisms involved Moreover, current interventions methods OPMDs discussed comprehension provide several prospective outlooks fields.

Язык: Английский

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Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance

Drug Resistance Updates, Год журнала: 2023, Номер 67, С. 100937 - 100937

Опубликована: Фев. 2, 2023

Язык: Английский

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The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential

Cancer Communications, Год журнала: 2021, Номер 41(10), С. 981 - 1006

Опубликована: Июль 20, 2021

Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in world, arises from interaction of multiple factors including tobacco, alcohol consumption, and betel quid. Chemotherapeutic agents such as cisplatin, 5-fluorouracil, paclitaxel have now become first-line options for OSCC patients. Nevertheless, patients eventually acquire drug resistance, leading to poor prognosis. With discovery identification non-coding RNAs (ncRNAs), functions dysregulated ncRNAs development resistance are gradually being widely recognized. The mechanisms intricate involve efflux, epithelial-mesenchymal transition, DNA damage repair, autophagy. At present, strategies explore reversal need be urgently developed. Nano-delivery self-cellular delivery platforms considered effective overcome due their tumor targeting, controlled release, consistent pharmacokinetic profiles. In particular, combined application new technologies (including CRISPR systems) opened up horizons treatment OSCC. Hence, this review explored emerging regulatory OSCC, elucidated ncRNA-meditated discussed potential value using nanoparticles self-cells carriers

Язык: Английский

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LncRNA-miRNA axis in tumor progression and therapy response: An emphasis on molecular interactions and therapeutic interventions

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 154, С. 113609 - 113609

Опубликована: Авг. 27, 2022

Epigenetic factors are critical regulators of biological and pathological mechanisms they could interact with different molecular pathways. Targeting epigenetic has been an idea approach in disease therapy, especially cancer. Accumulating evidence highlighted function long non-coding RNAs (lncRNAs) as cancer initiation development focused on their association downstream targets. microRNAs (miRNAs) the most well-known targets lncRNAs present review focuses lncRNA-miRNA axis malignancy therapy resistance tumors. LncRNA-miRNA regulates cell death such apoptosis autophagy cancers. This affects tumor metastasis via regulating EMT MMPs. Besides, determines sensitivity cells to chemotherapy, radiotherapy immunotherapy. Based studies, can be affected by drugs genetic tools this may affect expression level miRNAs targets, leading suppression/progression. LncRNAs have both tumor-promoting tumor-suppressor functions unique complicated implication therapy. also other signaling networks PI3K/Akt, STAT3, Wnt/β-catenin EZH2 among others. Notably, lncRNA/miRNA considered a signature for diagnosis prognosis

Язык: Английский

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Long non-coding RNAs (lncRNAs) signaling in cancer chemoresistance: From prediction to druggability

Drug Resistance Updates, Год журнала: 2022, Номер 65, С. 100866 - 100866

Опубликована: Сен. 20, 2022

Язык: Английский

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Effect of regulatory cell death on the occurrence and development of head and neck squamous cell carcinoma

Biomarker Research, Год журнала: 2023, Номер 11(1)

Опубликована: Янв. 5, 2023

Abstract Head and neck cancer is a malignant tumour with high mortality rate characterized by late diagnosis, recurrence metastasis rates, poor prognosis. squamous cell carcinoma (HNSCC) the most common type of head cancer. Various factors are involved in occurrence development HNSCC, including external inflammatory stimuli oncogenic viral infections. In recent years, studies on regulation death have provided new insights into biology therapeutic response such as apoptosis, necroptosis, pyroptosis, autophagy, ferroptosis, recently newly discovered cuproptosis. We explored how various deaths act unique defence mechanism against emergence they can be exploited to inhibit tumorigenesis progression, thus introducing regulatory (RCD) novel strategy for therapy. contrast accidental death, RCD controlled specific signal transduction pathways, TP53 signalling, KRAS NOTCH hypoxia metabolic reprogramming. this review, we describe molecular mechanisms nonapoptotic its relationship HNSCC discuss crosstalk between relevant signalling pathways cells. also highlight approaches elimination through RCD.

Язык: Английский

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Comprehensive review for non-coding RNAs: From mechanisms to therapeutic applications

Biochemical Pharmacology, Год журнала: 2024, Номер 224, С. 116218 - 116218

Опубликована: Апрель 21, 2024

Язык: Английский

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The Role of Biomarkers in HPV-Positive Head and Neck Squamous Cell Carcinoma: Towards Precision Medicine

Diagnostics, Год журнала: 2024, Номер 14(13), С. 1448 - 1448

Опубликована: Июль 7, 2024

Head and neck cancer (HNC) represents a significant global health challenge, with squamous cell carcinomas (SCCs) accounting for approximately 90% of all HNC cases. These malignancies, collectively referred to as head carcinoma (HNSCC), originate from the mucosal epithelium lining larynx, pharynx, oral cavity. The primary risk factors associated HNSCC in economically disadvantaged nations have been chronic alcohol consumption tobacco use. However, more affluent countries, landscape has shifted identification human papillomavirus (HPV) infection, particularly HPV-16, major factor, especially among nonsmokers. Understanding evolving distinct biological behaviors HPV-positive HPV-negative is critical developing targeted treatment strategies improving patient outcomes this complex diverse group cancers. Accurate diagnosis essential comprehensive model that integrates molecular characteristics, immune microenvironment, clinical outcomes. aim review was summarize current knowledge advances DNA, RNA, protein biomarkers bodily fluids tissues introduced new possibilities minimally or non-invasive diagnosis, monitoring, assessment therapeutic responses.

Язык: Английский

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Metabolic reprogramming driven by METTL1-mediated tRNA m7G modification promotes acquired anlotinib resistance in oral squamous cell carcinoma

Translational research, Год журнала: 2024, Номер 268, С. 28 - 39

Опубликована: Янв. 26, 2024

Язык: Английский

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Targeting Squalene Epoxidase Confers Metabolic Vulnerability and Overcomes Chemoresistance in HNSCC

Advanced Science, Год журнала: 2023, Номер 10(27)

Опубликована: Июль 25, 2023

Cisplatin resistance poses a substantial hurdle in effectively treating head and neck squamous cell carcinoma (HNSCC). Utilizing multiple tumor models examining an internal HNSCC cohort, squalene epoxidase (SQLE) is pinpointed as key driver of chemoresistance tumorigenesis, operating through cholesterol-dependent pathway. Comprehensive transcriptomic analysis reveals that SQLE essential for maintaining c-Myc transcriptional activity by stabilizing the protein averting its ubiquitin-mediated degradation. Mechanistic investigation demonstrates inhibition diminishes Akt's binding affinity to lipid rafts via process, subsequently deactivating raft-localized Akt, reducing GSK-3β phosphorylation at S9, increasing T58, ultimately leading destabilization. Importantly, employing Sqle conditional knockout mouse model, SQLE's critical role initiation progression established. The preclinical findings demonstrate potent synergistic effects combining terbinafine cisplatin arresting growth. These discoveries not only provide novel insights into underlying mechanisms SQLE-mediated tumorigenesis but also propose promising therapeutic avenue patients unresponsive conventional cisplatin-based chemotherapy.

Язык: Английский

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