Role of long non-coding RNAs in pancreatic cancer pathogenesis and treatment resistance- A review

Pathology - Research and Practice, Год журнала: 2023, Номер 245, С. 154438 - 154438

Опубликована: Апрель 6, 2023

Язык: Английский

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Long Noncoding RNA URB1-Antisense RNA 1 (AS1) Suppresses Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma by Driving Ferritin Phase Separation

ACS Nano, Год журнала: 2023, Номер 17(22), С. 22240 - 22258

Опубликована: Ноя. 15, 2023

Sorafenib, a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC), has been shown to be potent ferroptosis inducer in HCC. However, we found that there was lower level of sorafenib-resistant HCC samples than sorafenib-sensitive samples, suggesting sorafenib resistance may result suppression. Recent reports have long noncoding RNAs (lncRNAs) are involved programmed cell death (PCD), including apoptosis and ferroptosis. This study aimed investigate the roles underlying molecular mechanisms lncRNAs sorafenib-induced cells. Using lncRNA sequencing, identified ferroptosis-related lncRNA, URB1-antisense RNA 1 (AS1), which highly expressed predicted poor survival Furthermore, URB1-AS1 mitigates by inducing ferritin phase separation reducing cellular free iron content. Hypoxia inducible factor (HIF)-1α as key promoting expression Notably, specifically inhibiting with N-acetylgalactosamine (GalNAc)-small interfering (si)URB1-AS1 successfully enhanced sensitivity cells an vivo tumor model. Our uncovered critical role repression ferroptosis, targeting represent potential approach overcome

Язык: Английский

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LINC01852 inhibits the tumorigenesis and chemoresistance in colorectal cancer by suppressing SRSF5-mediated alternative splicing of PKM

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Янв. 24, 2024

Abstract Background Colorectal cancer (CRC) is a major cause of cancer-related deaths worldwide, and chemoresistance obstacle in its treatment. Despite advances therapy, the molecular mechanism underlying CRC not fully understood. Recent studies have implicated key roles long noncoding RNAs (lncRNAs) regulation chemoresistance. Methods In this study, we investigated role lncRNA LINC01852 expression was evaluated multiple cohorts using quantitative reverse transcription PCR. We conducted vitro vivo functional experiments cell culture mouse models. RNA pull-down, immunoprecipitation, chromatin dual luciferase assays were used to investigate CRC. Results Our findings revealed that with tumor-inhibiting properties, LINC01852, downregulated inhibited proliferation both vivo. Further mechanistic investigations increases TRIM72-mediated ubiquitination degradation SRSF5, inhibiting SRSF5-mediated alternative splicing PKM thereby decreasing production PKM2. Overexpression induces metabolic switch from aerobic glycolysis oxidative phosphorylation, which attenuates cells by PKM2-mediated glycolysis. Conclusions results demonstrate plays an important repressing malignancy regulating PKM, targeting LINC01852/TRIM72/SRSF5/PKM2 signaling axis may represent potential therapeutic strategy for

Язык: Английский

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The emerging role of noncoding RNAs in the PI3K/AKT/mTOR signalling pathway in breast cancer

Pathology - Research and Practice, Год журнала: 2024, Номер 255, С. 155180 - 155180

Опубликована: Янв. 30, 2024

Язык: Английский

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Natural products and long noncoding RNA signatures in gallbladder cancer: a review focuses on pathogenesis, diagnosis, and drug resistance

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(12), С. 9549 - 9571

Опубликована: Июль 19, 2024

Язык: Английский

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LncRNA HOTAIR regulates the expression of MRP1 gene through the mir-6807-5p/Egr1 axis to affect the multidrug resistance of lung cancer cells

Gene, Год журнала: 2025, Номер 940, С. 149216 - 149216

Опубликована: Янв. 5, 2025

Язык: Английский

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M6A-modified lncRNA FAM83H-AS1 promotes colorectal cancer progression through PTBP1

Cancer Letters, Год журнала: 2024, Номер 598, С. 217085 - 217085

Опубликована: Июль 2, 2024

LncRNA plays a crucial role in cancer progression and targeting, but it has been difficult to identify the critical lncRNAs involved colorectal (CRC) progression. We identified FAM83H-AS1 as tumor-promoting associated lncRNA using 21 pairs of stage IV CRC tissues adjacent normal tissues. In vitro vivo experiments revealed that knockdown cells inhibited tumor proliferation metastasis, vice versa. M6A modification is for RNA stability through writer METTL3 readers IGF2BP2/IGFBP3. PTBP1-an binding protein-is responsible function CRC. T4 (1770-2440 nt) T5 (2440-2743 on exon 4 provide platform PTBP1 RRM2 interactions. Our results demonstrated m6A dysregulated oncogenic by phosphorylated its splicing effect. patient-derived xenograft models, ASO-FAM83H-AS1 significantly suppressed growth gastrointestinal (GI) tumors, not only also GC ESCC. The combination oxaliplatin/cisplatin compared with treatment either agent alone. Notably, there was pathological complete response all these three GI cancers. findings suggest targeted therapy would benefit patients primarily receiving platinum-based

Язык: Английский

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Unraveling the influence of LncRNA in gastric cancer pathogenesis: a comprehensive review focus on signaling pathways interplay

Medical Oncology, Год журнала: 2024, Номер 41(9)

Опубликована: Авг. 5, 2024

Язык: Английский

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A signal-switchable photoelectrochemical biosensor for ultrasensitive detection of long non-coding RNA in cancer cells

Talanta, Год журнала: 2024, Номер 273, С. 125878 - 125878

Опубликована: Март 15, 2024

Язык: Английский

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Lnc-PHF3-3 aggravates the chemoresistance of osteosarcoma cells to doxorubicin via the miR-142-3p/HMGB1 axis

Translational Oncology, Год журнала: 2025, Номер 53, С. 102328 - 102328

Опубликована: Фев. 18, 2025

Язык: Английский

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