6′-O-Caffeoylarbutin from Quezui Tea: A Highly Effective and Safe Tyrosinase Inhibitor

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 972 - 972

Опубликована: Янв. 12, 2024

Tyrosinase is vital in fruit and vegetable browning melanin synthesis, crucial for food preservation pharmaceuticals. We investigated 6'-

Язык: Английский

---

Vaccinium Species—Unexplored Sources of Active Constituents for Cosmeceuticals

Biomolecules, Год журнала: 2024, Номер 14(9), С. 1110 - 1110

Опубликована: Сен. 3, 2024

The genus

Язык: Английский

---

Investigation of the Inhibitory Activity of β‐Arbutin and Its Analogues on Tyrosinase Based on Molecular Docking and Enzyme Inhibition Kinetics

Chemistry & Biodiversity, Год журнала: 2024, Номер unknown

Опубликована: Окт. 7, 2024

β-Arbutin, a natural glucoside hydroquinone derivative known for its skin-whitening properties through tyrosinase inhibition in melanin synthesis, may pose potential risks of allergy and carcinogenicity due to the release during use. This study explores inhibitory effects phenyl-β-D-pyranoglucoside (compound 1), 4-methoxyphenyl-β-D-pyranoglucoside 2), 4-hydroxymethylphenyl-β-D-pyranoglucoside 3), β-arbutin 4) on using enzyme kinetics, molecular docking, dynamics simulations. Results show compounds 1, 3, 4 exhibit competitive inhibition, while compound 2 shows mixed inhibition. Docking analysis reveals phenyl rings all interact with enzyme's active site, 3 forming metal bond copper ions. MD simulations indicate high stability 2, 4, showing lowest RMSD compact Rg, suggesting stronger binding. Compound 1 is less stable inhibitory. These insights are valuable designing effective inhibitors.

Язык: Английский

---

Phenolic Profile, Bioactivities and In Silico Analysis of the Trunk Bark of Acacia Cyanophylla Lindl.

Chemistry & Biodiversity, Год журнала: 2024, Номер 21(8)

Опубликована: Июль 4, 2024

In the current investigation, total phenolics and flavonoids of methanolic extract obtained from trunk bark Acacia cyanophylla Lindl. were quantified by LC-HRMS technique. DPPH ABTS reagents employed to assay antioxidant potential. The anti-tyrosinase anti-α-amylase potentials also assayed. findings revealed that thirteen polyphenolic compounds detected in with trans-taxifolin (23.2 g/kg), as major constituent. A. displayed a higher activity test (IC

Язык: Английский

---

Application of subcritical and supercritical fluid extraction in food processing

Elsevier eBooks, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

---

Revealing the dynamic changes of metabolites and molecular mechanisms of chlorogenic acid accumulation during the leaf development of Vaccinium dunalianum based on multi-omic analyses

Frontiers in Plant Science, Год журнала: 2024, Номер 15

Опубликована: Окт. 31, 2024

, a medicinal plant, is utilized for Quezui Tea production from its leaf buds and young leaves. Despite prior research on

Язык: Английский

---

Recent developments in subcritical water extraction of industrially important bioactive substances from plants, microorganisms, and organic wastes

Biomass Conversion and Biorefinery, Год журнала: 2024, Номер unknown

Опубликована: Дек. 19, 2024

Язык: Английский

---