Small-Molecule Tyrosinase Inhibitors for Treatment of Hyperpigmentation
Molecules,
Год журнала:
2025,
Номер
30(4), С. 788 - 788
Опубликована: Фев. 8, 2025
Increasing
attention
is
being
focused
on
skin
health
currently,
especially
the
excessive
deposition
of
melanin
in
skin.
Tyrosinase,
rate-limiting
enzyme
biosynthesis,
a
crucial
synthesis.
However,
existing
tyrosinase
inhibitors
pose
some
degree
toxicity
to
humans.
Therefore,
development
more
efficient
and
low-toxicity
urgently
needed.
This
review
briefly
depicts
biosynthesis
process
crystal
structure
catalytic
mechanism
tyrosinase.
The
latest
research
progress
regarding
small-molecule
also
reviewed.
Moreover,
structure-function
relationships
are
analyzed
summarized.
expected
provide
new
scientific
insights
enable
researchers
explore
safer
potent
inhibitors.
Язык: Английский
Grafted modified chitosan/pullulan film loaded with essential oil/β-CD-MOFs for freshness preservation of peach
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
306, С. 141491 - 141491
Опубликована: Фев. 27, 2025
Язык: Английский
Biomedical applications of tyrosinases and tyrosinase inhibitors
The Enzymes,
Год журнала:
2024,
Номер
unknown, С. 261 - 280
Опубликована: Янв. 1, 2024
Язык: Английский
Computational studies of tyrosinase inhibitors
The Enzymes,
Год журнала:
2024,
Номер
unknown, С. 191 - 229
Опубликована: Янв. 1, 2024
Язык: Английский
Investigation of the Inhibitory Activity of β‐Arbutin and Its Analogues on Tyrosinase Based on Molecular Docking and Enzyme Inhibition Kinetics
Yuxiu Lv,
Chuanhui Yao,
Kangjia Han
и другие.
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 7, 2024
β-Arbutin,
a
natural
glucoside
hydroquinone
derivative
known
for
its
skin-whitening
properties
through
tyrosinase
inhibition
in
melanin
synthesis,
may
pose
potential
risks
of
allergy
and
carcinogenicity
due
to
the
release
during
use.
This
study
explores
inhibitory
effects
phenyl-β-D-pyranoglucoside
(compound
1),
4-methoxyphenyl-β-D-pyranoglucoside
2),
4-hydroxymethylphenyl-β-D-pyranoglucoside
3),
β-arbutin
4)
on
using
enzyme
kinetics,
molecular
docking,
dynamics
simulations.
Results
show
compounds
1,
3,
4
exhibit
competitive
inhibition,
while
compound
2
shows
mixed
inhibition.
Docking
analysis
reveals
phenyl
rings
all
interact
with
enzyme's
active
site,
3
forming
metal
bond
copper
ions.
MD
simulations
indicate
high
stability
2,
4,
showing
lowest
RMSD
compact
Rg,
suggesting
stronger
binding.
Compound
1
is
less
stable
inhibitory.
These
insights
are
valuable
designing
effective
inhibitors.
Язык: Английский
An examination of natural and synthetic tyrosinase inhibitors
European Journal of Life Sciences,
Год журнала:
2024,
Номер
3(3), С. 114 - 126
Опубликована: Дек. 31, 2024
The
enzyme
responsible
for
this
process
is
known
as
tyrosinase,
which
sometimes
referred
to
polyphenol
oxidase,
monophenol
phenolase,
or
catecholase.
It
present
in
humans,
plants,
microbes,
and
fungi.
Melanin
pigments,
found
both
plants
animals,
require
an
essential
component.
Tyrosinase
animal
creatures,
particularly
the
pigments
of
skin,
hair,
eyes.
can
cause
darkening
foods
that
unrelated
their
inherent
color.
Beverages
such
fruit
juice
wine
may
experience
a
decline
appearance
flavor,
well
occurrence
turbidity
precipitation.
unwanted
phenomenon
browning
fruits
vegetables,
frequently
caused
by
enzymatic
processes,
needs
be
avoided.
inhibitors
are
employed
hinder
catalytic
oxidations
lead
tyrosinase
enzyme.
Currently,
these
basic
ingredients
commonly
skin
whitening
solutions,
field
cosmetics.
In
addition,
have
practical
applications
treatment
problems
associated
with
melanin
pigmentation.
Furthermore,
competitively
reversibly
activity
human
melanocyte
hence
impeding
production
melanin.Numerous
substances
possess
ability
tyrosinase.
Ongoing
studies
being
conducted
on
several
derivatized
compounds
increase
inhibition.
This
article
explores
inhibitory
effects
many
compounds,
including
kojic
acid,
azelaic
flavonoids,
arbutin-deoxyarbutin,
curcumin
its
derivatives,
copper
chelators,
Язык: Английский