Jordan Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
17(4), С. 794 - 810
Опубликована: Дек. 20, 2024
The
word
"Phyto"
signifies
plant,
while
"some"
is
for
cell.
This
innovative
patented
technology
involves
combining
plant
extracts
or
hydrophilic
phytoconstituents
with
phospholipids
to
create
lipid-suitable
molecular
complexes,
resulting
in
not
only
enhanced
absorption
but
also
bioavailability.
Extensive
research
has
been
conducted
by
various
scientists
explore
the
transdermal
way
as
an
excellent
method
delivering
phytoconstituents.
Phyto
products
are
gaining
significant
consideration
dietary
complements
managing
inflammation,
toxicity,
cancer,
weight
loss,
and
chronic
degenerative
conditions.
Nevertheless,
continuous
advancements
studies
being
this
fieldthese
frequently
encounter
issues
stability
Once
extracted,
become
susceptible
instability
may
be
suitable
passage
through
a
biological
membrane.
technique
enhances
hydrophilicity
of
highly
lipophilic
drugs,
manufacturing
them
convenient
drug
delivery,
adequately
enhance
lipophilicity
constituents
facilitate
permeation
bio-
use
Phytosomes
beautifying
purposes
already
scientifically
established.
Additionally,
review
offers
relative
analysis
liposomes
Phytosomes,
highlighting
current
developments
technology,
mostly
delivery.
Incorporation
polyphenol
compounds
into
self-assembled
phospholipid-based
delivery
system,
known
can
significantly
improve
their
poor
oral
The
incidence
of
cancer
is
increasing
and
evolving
as
a
major
source
mortality.
Nanotechnology
has
garnered
considerable
scientific
interest
in
recent
decades
can
offer
promising
solution
to
the
challenges
encountered
with
traditional
chemotherapy.
Nanoparticle
utilization
holds
promise
combating
other
diseases,
offering
exciting
prospects
for
drug
delivery
systems
medicinal
applications.
Metallic
nanoparticles
exhibit
remarkable
physical
chemical
properties,
such
their
minute
size,
composition,
structure,
extensive
surface
area,
rendering
them
versatile
cost-effective.
Research
demonstrated
significant
beneficial
impact
on
treatment,
characterized
by
enhanced
targeting
abilities,
gene
activity
suppression,
improved
efficiency.
By
incorporating
ligands,
functionalized
metal
ensure
precise
energy
deposition
within
tumors,
thereby
augmenting
treatment
accuracy.
Moreover,
beyond
therapeutic
efficacy,
serve
valuable
tools
cell
visualization,
contributing
diagnostic
techniques.
Utilizing
allows
simultaneous
diagnosis
while
also
facilitating
controlled
release,
thus
revolutionizing
care.
This
narrative
review
investigates
advancements
types
mechanisms
cells,
application
clinical
scenarios,
potential
toxicity
medicine.
Abstract
This
study
described
a
hyaluronic
acid
(HA)
coated
niosomes
(Nio)
encapsulated
curcumin
(CRM)
(CRM‐HA‐Nio)
to
improve
therapeutic
properties
via
targeted
delivery.
CRM‐HA‐Nio
was
prepared
by
thin
film
hydration
method
and
characterized
dynamic
light
scattering
transmission
electron
microscopy.
Release
assay
performed
utilizing
dialysis
method.
Antioxidant,
Cell
viability,
cellular
uptake
assays
were
evaluate
the
biological
activity.
has
142.93±39.71
nm
size
with
−20.67±1.10
charge
showed
good
stability
93±4.35
%
encapsulation
efficiency
displayed
pH‐independent
release
pattern.
2‐fold
antioxidant
improvement
compared
free
CRM.
much
better
cytotoxic
activity
on
MCF‐7
cell
line
IC
50
of
1.851±0.45
μM
CRM
equal
5.230±0.85
μM,
approximately
3‐fold
enhancement.
may
be
promising
nanocarrier
elucidate
bioactivity
against
cancer
when
oxidative
stress
is
major
side
effect.
Biomedical Chromatography,
Год журнала:
2024,
Номер
38(8)
Опубликована: Май 26, 2024
Abstract
Nanoliposomes
(NLs)
are
ideal
carriers
for
delivering
complex
molecules
and
phytochemical
products,
but
ginger
by‐products,
despite
their
therapeutic
benefits,
have
poor
bioavailability
due
to
low
water
solubility
stability.
Crude
extracts
(CGEs)
6‐gingerol
were
individually
encapsulated
within
NLs
in
vitro
activity
assessment.
In
evaluation
of
anti‐proliferative
anti‐inflammatory
properties
CGE
was
performed
on
healthy
human
periodontal
ligament
(PDL)
fibroblasts
MDA‐MB‐231
breast
cancer
cells.
Encapsulation
efficiency
loading
capacity
reached
25.23%
2.5%,
respectively.
found
stable
up
30
days
at
4°C
with
a
gradual
load
loss
20%.
cytotoxic
effect
exceeded
70%
the
cell
line,
comparable
manner
non‐encapsulated
CGE.
The
an
IC
50
3.11
±
0.39,
7.14
0.80,
0.82
0.55
μM
inhibiting
IL‐8
evident,
indicating
its
potential
activity.
Encapsulating
enhanced
stability
facilitated
biological
All
compounds,
including
vitamin
C,
equivalent
concentrations
below
2
mg/mL,
slight
difference
antioxidant
capable
50%
2,2‐diphenyl‐1‐picrylhydrazyl
(DPPH)
substrate
comparable.
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
21(2), С. 309 - 324
Опубликована: Янв. 29, 2024
The
resistance
to
chemotherapy
is
a
significant
hurdle
in
breast
cancer
treatment,
prompting
the
exploration
of
innovative
strategies.
This
review
discusses
potential
dual-loaded
liposomal
carriers
combat
chemoresistance
and
improve
outcomes
for
patients.
Chemistry & Biodiversity,
Год журнала:
2023,
Номер
20(11)
Опубликована: Окт. 2, 2023
The
abstract
discusses
the
development
of
rutin-loaded
nanoliposomes
and
their
anti-colorectal
cancer
activity
against
human
carcinoma
cells
(HT-29).
study
characterizes
using
thin-film
hydration
method
analyzes
size,
charge,
polydispersity
index.
encapsulation
efficiency
drug
loading
ability
rutin
at
different
concentrations
were
investigated.
found
to
be
stable
for
up
one
month
4
°C
showed
sustained
release
24
h.
anti-cancer
was
concentration-dependent
significantly
improved
compared
free
rutin.
PEGylated
with
(1.8
mg/ml)
highest
ability,
along
selectivity
cells.
Overall,
provides
important
insights
into
potential
use
treatment
colorectal
cancer.
PLoS ONE,
Год журнала:
2025,
Номер
20(3), С. e0315771 - e0315771
Опубликована: Март 18, 2025
Background
Coumarin
is
a
natural
bioactive
compound
found
in
many
plants
and
acquires
antibacterial,
antioxidant
anticoagulant
activities.
The
antibacterial
activity
of
coumarin
has
never
been
tested
after
being
encapsulated
liposomes.
This
study
was
carried
out
to
screen
the
main
functional
components
Rubus
canescens
DC
crude
extract
(CE),
develop
nanoliposome,
test
its
anti-bacterial
properties.
Methods
R.
CE
screened
for
compounds
using
liquid
chromatography-mass
spectrometry
(LC-MS).
Pure
commercial
loaded
into
liposomes
characterized
terms
surface
morphology,
hydrodynamic
diameter,
zeta
potential,
encapsulation
efficiency
(EE).
evaluated
against
ascorbic
acid.
both
alone
liposome-encapsulated
Staphylococcus
aureus
,
Salmonella
typhimurium
Pseudomonas
aeruginosa
inoculated
soft
white
cheese
(SWC)
also
evaluated.
Results
predominant
constituent
CE,
coumarin.
Comparing
DPPH
scavenging
that
acid,
exhibited
an
insignificant
effect
(p
≥
0.05).
minimum
inhibitory
concentration
(MIC)
values
P.
E.
coli
Staph.
S.
L.
monocytogenes
were
2.5,
1.25,
1.25
µg/ml,
respectively.
bactericidal
(MBC)
these
microorganisms
5,
2.5
successfully
nanoliposomes,
which
had
polydispersity
index
(PDI)
0.36
±
0.35
Đ,
diameter
127.8
0.3
nm,
zeta-potential
-61.03
2.9
mV,
EE
40.93
0.2%.
Both
liposome
with
showed
effects
bacterial
strains
SWC
over
30-day
storage
period
at
4
°
C.
Conclusions
formulated
.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(4), С. 573 - 573
Опубликована: Апрель 15, 2025
Oleuropein
is
a
natural
polyphenolic
compound
isolated
from
olive
trees
(Olea
europaea).
Besides
the
strong
antioxidant
effect
of
oleuropein,
it
has
many
pharmacological
activities
such
as
anticancer,
antidiabetic,
anti-inflammatory,
antihypertensive,
and
other
activities.
Thus,
oleuropein
could
be
used
alone
or
with
drugs
to
prevent
treat
diseases.
Despite
its
promising
health
benefits,
highly
prone
hydrolysis
inside
outside
human
body,
in
addition
poorly
identified
pharmacokinetic
profile
poor
bioavailability.
Many
nanocarrier
delivery
systems
have
overcome
limitations
order
maximize
therapeutic
benefits.
Therefore,
this
review
article
sheds
light
on
nano-delivery
explored
until
current
date,
aiming
enhance
oleuropein’s
bioavailability
impact
by
improving
properties
addressing
stability
challenges.
Continued
research
into
innovative
nanotechnology
solutions
will
crucial
unlocking
full
potential
powerful
nutraceutical
pharmaceutical
agent.
