Phytosomes: A Cutting-Edge Platform for Phytochemicals Delivery by Enhancing Bioavailability DOI Creative Commons

Smita Kumbhar,

Vaishnavi Jagdale,

Manish S. Bhatia

et al.

Jordan Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 17(4), P. 794 - 810

Published: Dec. 20, 2024

The word "Phyto" signifies plant, while "some" is for cell. This innovative patented technology involves combining plant extracts or hydrophilic phytoconstituents with phospholipids to create lipid-suitable molecular complexes, resulting in not only enhanced absorption but also bioavailability. Extensive research has been conducted by various scientists explore the transdermal way as an excellent method delivering phytoconstituents. Phyto products are gaining significant consideration dietary complements managing inflammation, toxicity, cancer, weight loss, and chronic degenerative conditions. Nevertheless, continuous advancements studies being this fieldthese frequently encounter issues stability Once extracted, become susceptible instability may be suitable passage through a biological membrane. technique enhances hydrophilicity of highly lipophilic drugs, manufacturing them convenient drug delivery, adequately enhance lipophilicity constituents facilitate permeation bio- use Phytosomes beautifying purposes already scientifically established. Additionally, review offers relative analysis liposomes Phytosomes, highlighting current developments technology, mostly delivery. Incorporation polyphenol compounds into self-assembled phospholipid-based delivery system, known can significantly improve their poor oral

Language: Английский

Hyaluronic Acid – Coated Niosomes for Curcumin Targeted Delivery into Breast Cancer Cells DOI

Zahraa M. Al Zubaidi,

Hamdi Nsairat, Naeem Shalan

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(3)

Published: Jan. 17, 2024

Abstract This study described a hyaluronic acid (HA) coated niosomes (Nio) encapsulated curcumin (CRM) (CRM‐HA‐Nio) to improve therapeutic properties via targeted delivery. CRM‐HA‐Nio was prepared by thin film hydration method and characterized dynamic light scattering transmission electron microscopy. Release assay performed utilizing dialysis method. Antioxidant, Cell viability, cellular uptake assays were evaluate the biological activity. has 142.93±39.71 nm size with −20.67±1.10 charge showed good stability 93±4.35 % encapsulation efficiency displayed pH‐independent release pattern. 2‐fold antioxidant improvement compared free CRM. much better cytotoxic activity on MCF‐7 cell line IC 50 of 1.851±0.45 μM CRM equal 5.230±0.85 μM, approximately 3‐fold enhancement. may be promising nanocarrier elucidate bioactivity against cancer when oxidative stress is major side effect.

Language: Английский

Citations

9
Advancements of metallic nanoparticles: A promising frontier in cancer treatment DOI Creative Commons
Ali Al‐Samydai, Maha N. Abu Hajleh,

Farah Al-Sahlawi

et al.

Science Progress, Journal Year: 2024, Volume and Issue: 107(4)

Published: Oct. 1, 2024

The incidence of cancer is increasing and evolving as a major source mortality. Nanotechnology has garnered considerable scientific interest in recent decades can offer promising solution to the challenges encountered with traditional chemotherapy. Nanoparticle utilization holds promise combating other diseases, offering exciting prospects for drug delivery systems medicinal applications. Metallic nanoparticles exhibit remarkable physical chemical properties, such their minute size, composition, structure, extensive surface area, rendering them versatile cost-effective. Research demonstrated significant beneficial impact on treatment, characterized by enhanced targeting abilities, gene activity suppression, improved efficiency. By incorporating ligands, functionalized metal ensure precise energy deposition within tumors, thereby augmenting treatment accuracy. Moreover, beyond therapeutic efficacy, serve valuable tools cell visualization, contributing diagnostic techniques. Utilizing allows simultaneous diagnosis while also facilitating controlled release, thus revolutionizing care. This narrative review investigates advancements types mechanisms cells, application clinical scenarios, potential toxicity medicine.

Language: Английский

Citations

9
Encapsulation of gingerol into nanoliposomes: Evaluation of in vitro anti‐inflammatory and anti‐cancer activity DOI
Fatima Ahmed Alshaikh, Ali Al‐Samydai,

Reem Issa

et al.

Biomedical Chromatography, Journal Year: 2024, Volume and Issue: 38(8)

Published: May 26, 2024

Abstract Nanoliposomes (NLs) are ideal carriers for delivering complex molecules and phytochemical products, but ginger by‐products, despite their therapeutic benefits, have poor bioavailability due to low water solubility stability. Crude extracts (CGEs) 6‐gingerol were individually encapsulated within NLs in vitro activity assessment. In evaluation of anti‐proliferative anti‐inflammatory properties CGE was performed on healthy human periodontal ligament (PDL) fibroblasts MDA‐MB‐231 breast cancer cells. Encapsulation efficiency loading capacity reached 25.23% 2.5%, respectively. found stable up 30 days at 4°C with a gradual load loss 20%. cytotoxic effect exceeded 70% the cell line, comparable manner non‐encapsulated CGE. The an IC 50 3.11 ± 0.39, 7.14 0.80, 0.82 0.55 μM inhibiting IL‐8 evident, indicating its potential activity. Encapsulating enhanced stability facilitated biological All compounds, including vitamin C, equivalent concentrations below 2 mg/mL, slight difference antioxidant capable 50% 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) substrate comparable.

Language: Английский

Citations

8
Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer DOI
Mohamed El‐Tanani, Hamdi Nsairat, Alaa A. A. Aljabali

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(2), P. 309 - 324

Published: Jan. 29, 2024

The resistance to chemotherapy is a significant hurdle in breast cancer treatment, prompting the exploration of innovative strategies. This review discusses potential dual-loaded liposomal carriers combat chemoresistance and improve outcomes for patients.

Language: Английский

Citations

7
Advancements in nanotechnology for the delivery of phytochemicals DOI
Divya Chauhan, Pavan Kumar Yadav, Nazneen Sultana

et al.

Journal of Integrative Medicine, Journal Year: 2024, Volume and Issue: 22(4), P. 385 - 398

Published: April 24, 2024

Language: Английский

Citations

7
Preparation, Characterization, and Anticancer Activity of PEGylated Nano Liposomal Loaded with Rutin against Human Carcinoma Cells (HT‐29) DOI

Noorin Manhal Al‐Ekaid,

Ali Al‐Samydai, Ibrahim Al‐Deeb

et al.

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 20(11)

Published: Oct. 2, 2023

The abstract discusses the development of rutin-loaded nanoliposomes and their anti-colorectal cancer activity against human carcinoma cells (HT-29). study characterizes using thin-film hydration method analyzes size, charge, polydispersity index. encapsulation efficiency drug loading ability rutin at different concentrations were investigated. found to be stable for up one month 4 °C showed sustained release 24 h. anti-cancer was concentration-dependent significantly improved compared free rutin. PEGylated with (1.8 mg/ml) highest ability, along selectivity cells. Overall, provides important insights into potential use treatment colorectal cancer.

Language: Английский

Citations

15
The role of quercetin in NLRP3-associated inflammation DOI

Jiaqi Wu,

Tongtong Lv, Yü Liu

et al.

Inflammopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 22, 2024

Language: Английский

Citations

6
Innovative liposomal coumarin: A promising solution for enhancing soft white cheese quality DOI Creative Commons

Salameh Alqaraleh,

Laila Al-Omari, Ghadeer F. Mehyar

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0315771 - e0315771

Published: March 18, 2025

Background Coumarin is a natural bioactive compound found in many plants and acquires antibacterial, antioxidant anticoagulant activities. The antibacterial activity of coumarin has never been tested after being encapsulated liposomes. This study was carried out to screen the main functional components Rubus canescens DC crude extract (CE), develop nanoliposome, test its anti-bacterial properties. Methods R. CE screened for compounds using liquid chromatography-mass spectrometry (LC-MS). Pure commercial loaded into liposomes characterized terms surface morphology, hydrodynamic diameter, zeta potential, encapsulation efficiency (EE). evaluated against ascorbic acid. both alone liposome-encapsulated Staphylococcus aureus , Salmonella typhimurium Pseudomonas aeruginosa inoculated soft white cheese (SWC) also evaluated. Results predominant constituent CE, coumarin. Comparing DPPH scavenging that acid, exhibited an insignificant effect (p ≥ 0.05). minimum inhibitory concentration (MIC) values P. E. coli Staph. S. L. monocytogenes were 2.5, 1.25, 1.25 µg/ml, respectively. bactericidal (MBC) these microorganisms 5, 2.5 successfully nanoliposomes, which had polydispersity index (PDI) 0.36 ± 0.35 Đ, diameter 127.8 0.3 nm, zeta-potential -61.03 2.9 mV, EE 40.93 0.2%. Both liposome with showed effects bacterial strains SWC over 30-day storage period at 4 ° C. Conclusions formulated .

Language: Английский

Citations

0
Current strategies for rutin nano-formulation; a promising bioactive compound with increased efficacy DOI

Maryam Malekpour,

Alireza Ebrahiminezhad, Zeinab Karimi

et al.

Bioprocess and Biosystems Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Language: Английский

Citations

0
From Olive Tree to Treatment: Nano-Delivery Systems for Enhancing Oleuropein’s Health Benefits DOI Creative Commons
Maha Nasr,

Salma H. Katary

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 573 - 573

Published: April 15, 2025

Oleuropein is a natural polyphenolic compound isolated from olive trees (Olea europaea). Besides the strong antioxidant effect of oleuropein, it has many pharmacological activities such as anticancer, antidiabetic, anti-inflammatory, antihypertensive, and other activities. Thus, oleuropein could be used alone or with drugs to prevent treat diseases. Despite its promising health benefits, highly prone hydrolysis inside outside human body, in addition poorly identified pharmacokinetic profile poor bioavailability. Many nanocarrier delivery systems have overcome limitations order maximize therapeutic benefits. Therefore, this review article sheds light on nano-delivery explored until current date, aiming enhance oleuropein’s bioavailability impact by improving properties addressing stability challenges. Continued research into innovative nanotechnology solutions will crucial unlocking full potential powerful nutraceutical pharmaceutical agent.

Language: Английский

Citations

0