A mechanistic insight into the anticancer potentials of resveratrol: Current perspectives

Phytotherapy Research, Год журнала: 2024, Номер 38(8), С. 3877 - 3898

Опубликована: Май 20, 2024

Abstract Resveratrol is a widely recognized polyphenolic phytochemical found in various plants and their fruits, such as peanuts, grapes, berry fruits. It renowned for its several health advantages. The well known anticancer properties, substantial amount of clinical evidence has also established promise chemotherapeutic agent. This study focuses on assessing the properties resveratrol gaining insight into underlying molecular mechanisms. evaluates biopharmaceutical, toxicological characteristics, utilization to determine suitability further development reliable Therefore, information about preclinical studies was collected from different electronic databases up‐to‐date (2018–2023). Findings this revealed that potent therapeutic benefits against cancers involving mechanisms, induction oxidative stress, cytotoxicity, inhibition cell migration invasion, autophagy, arresting S phase cycle, apoptotic, anti‐angiogenic, antiproliferative effects by regulating pathways including PI3K/AKT, p38/MAPK/ERK, NGFR‐AMPK‐mTOR, so on. However, compound poor oral bioavailability due reduced absorption; limitation overcome applying nanotechnology (nanoformulation resveratrol). Clinical application showed types cancer with no serious adverse effects. We suggest additional extensive check efficacy, safety, long‐term hazards. could involve larger number samples establish drug treatment cancer.

Язык: Английский

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GabaAergic sedative prospection of sclareol-linalool co-treatment: An antagonistic intervention through in vivo and in silico studies

Neuroscience Letters, Год журнала: 2024, Номер unknown, С. 138060 - 138060

Опубликована: Ноя. 1, 2024

Язык: Английский

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Modulatory Sedative Activity of Abrine on Diazepam in Thiopental Sodium Mediated Sleeping Mice: An In Vivo Approach with Receptor Binding Affinity of GABAergic Transmission

ChemistrySelect, Год журнала: 2024, Номер 9(37)

Опубликована: Сен. 30, 2024

Abstract The current study aims to assess the effects of abrine (ABR) in thiopental sodium (TS)‐induced sleeping mice and explore sedative impacts compound by using vivo silico investigations. ABR (5 10 mg k −1 g, i.p.) diazepam (DZP) (2 were administered experimental animals either single or combined. TS (20 was induce sleep, latency with duration observed for 3 h. investigation conducted predict role gamma‐aminobutyric acid A (GABA ) receptor process evaluate pharmacokinetics toxicity. Results showed that (10 g) significantly ( p < 0.05) decreased period (8.20 ± 1.85 min) enhanced sleep (187.8 8.87 comparison control group. Additionally, co‐treatments DZP remarkably reduced (4.40 0.24 increased (201.40 5.89 compared therapy. molecular docking indicated has a binding affinity −7.4 kcal/mol GABA receptor. In conclusion, provides strong synergistic efficacy on TS‐induced via GABAergic system.

Язык: Английский

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Therapeutic Efficacy Studies on the Monoterpenoid Hinokitiol in the Treatment of Different Types of Cancer

Chemistry & Biodiversity, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

ABSTRACT Hinokitiol (HK), a monoterpenoid that naturally occurs in plants belonging to the Cupressaceae family, possesses important biological activities, including an anticancer effect. This review summarizes its potential and draws possible molecular interventions. In addition, it evaluates biopharmaceutical, toxicological properties, clinical application of HK establish viability for future advancement as dependable medication. The assessment is based on most recent information available from various databases. Findings demonstrate substantial therapeutic advantages against diverse types cancer (colon, cervical, breast, bone, endometrial, liver, prostate, oral, skin) through mechanisms. induces oxidative stress, cytotoxicity, apoptosis, cell‐cycle arrest at G S phases, autophagy modulation phosphatidylinositol 3‐kinase (PI3K)/Akt/mammalian target rapamycin (mTOR), p38/ERK/MAPK, nuclear factor kappa B, c‐Jun N‐terminal kinase signaling pathways. Furthermore, this compound exhibits good oral bioavailability with excellent plasma clearance. Clinical uses without any significant negative effects. A thorough study pertinent data suggests may serve viable candidate developing novel therapies. Consequently, more extensive studies are necessary evaluate treatment efficacy, safety, long‐term hazards.

Язык: Английский

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Caffeine and sclareol take the edge off the sedative effects of linalool, possibly through the GABAA interaction pathway: molecular insights through in vivo and in silico studies

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Язык: Английский

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Therapeutic Efficacy of Quercetin and Its Nanoformulation Both the Mono‐ or Combination Therapies in the Management of Cancer: An Update with Molecular Mechanisms

Journal of Tropical Medicine, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Quercetin, a major representative of the flavonol subclass found abundantly in almost all edible vegetables and fruits, showed remarkable therapeutic properties was beneficial numerous degenerative diseases by preventing lipid peroxidation. Quercetin is different diseases, such as atherosclerosis chronic inflammation. This study aims to find out anticancer activities quercetin determine mechanisms pathways which are responsible for effect. It also revealed biopharmaceutical, toxicological characteristics, clinical utilization evaluate its suitability further investigations reliable drug. All relevant data concerning this compound with cancer collected using scientific search engines, including PubMed, Springer Link, Wiley Online, Web Science, SciFinder, ScienceDirect, Google Scholar. review demonstrated that strong properties, apoptosis, inhibition cell proliferation, autophagy, cycle arrest, angiogenesis, invasion migration against various types cancer. Findings could significantly moderate regulate pathways, PI3K/AKT‐mTORC1 pathway, JAK/STAT signaling system, MAPK MMP NF‐ κ B p‐Camk2/p‐DRP1 pathway. However, poor oral bioavailability due reduced absorption; limitation overcome applying nanotechnology (nanoformulation quercetin). Moreover, expressed no toxic effect investigated subjects. Based on view these findings, it might be considered chemotherapeutic drug candidate treatment cancers. more studies suggested establish proper efficacy, safety, human dose.

Язык: Английский

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Therapeutic Promises of Ferulic Acid and its Derivatives on Hepatic damage Related with Oxidative Stress and Inflammation: A Review with Mechanisms

Chemistry & Biodiversity, Год журнала: 2024, Номер 21(7)

Опубликована: Май 17, 2024

Ferulic acid (FA) is a naturally occurring phenolic compound commonly found in the plant Ferula communis. This study aims to investigate hepatoprotective effect of FA and its derivatives (methyl ferulic trans-ferulic acid) against oxidative stress inflammation-related hepatotoxicity due toxicants based on results different non-clinical preclinical tests. For this, data was collected from reliable electronic databases such as PubMed, Google Scholar, ScienceDirect, etc. The this investigation demonstrated that have potent effects damage. findings also revealed these protective are antioxidant anti-inflammatory chemical compound. analogues significantly inhibit free radical generation hinder proinflammatory markers inflammatory enzymes, resulting diminished cytotoxic apoptotic hepatocyte death. compounds prevent intracellular lipid accumulation provide effects.

Язык: Английский

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Metabolome and comparative genome provide insights into secondary metabolites generation of a rare karst‐growing Rhododendron in vitro culture

The Plant Journal, Год журнала: 2025, Номер 121(3)

Опубликована: Фев. 1, 2025

SUMMARY Rhododendron species have the potential to be rich in secondary metabolites with pharmaceutical or industrial value. However, there is a lack of comprehensive metabolome studies at genome level, particularly for unique and rare like bailiense , which exclusively grows karst environments Guizhou, southwest China. Recently, assembly data this was available. In study, nontargeted metabolomics employed investigate profile R. callus. The callus induced using 0.2 mg L −1 TDZ (Thidiazuron) + 0.1 IBA (3‐Indole butyric acid). A comparison between light‐treated calli dark‐cultured revealed differential accumulation metabolites, flavonoids, terpenoids, coumarins, hydroxycinnamic acids, known their beneficial effects such as antioxidant, anticancer, anti‐inflammatory properties. Proanthocyanidins, various health‐promoting effects, were found accumulate significantly calli. Light conditions promoted diterpene triterpene products, whereas darkness favored sesquiterpene products. Additionally, study demonstrated utilizing Agrobacterium transformation technology on suspension cells enhance metabolite production. Comparison molle that exhibited active ‘glycosyltransferase activity,’ possessed higher number copies monoterpene terpene synthases, contained high specific cytochrome P450 members (CYP71, CYP76, CYP79, CYP82, CYP736). This offers valuable insights strategies biosynthesis production significance.

Язык: Английский

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Exploring the Antiemetic Potential of Caffeic Acid: A Combined In Vivo and Computational Approach

Neurogastroenterology & Motility, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

ABSTRACT Background This study emphasizes evaluating the antiemetic efficacy of natural food component caffeic acid (CAF) using a copper sulfate pentahydrate (CuSO 4 .5H 2 O)‐induced emetic model on chicks, and an in silico approach was also adopted to estimate possible underlying mechanisms. Methods Two doses (25 50 mg/kg b.w.) CAF several referral drugs considered positive controls (PCs), including domperidone (6 mg/kg), hyoscine (21 aprepitant (16 diphenhydramine (10 ondansetron (5 were orally administered chicks. The vehicle served as control group. Co‐treatments with provided chicks evaluate modulatory action test compound. Results According results, delayed onset decreased frequency retches dose‐dependent manner compared (40 mg/kg) represented notable latency period (60.17 ± 3.16 s) diminished number retchings (18.33 1.74 times) Further, co‐treatments, increased reduced retches, except for domperidone. In investigation, showed binding affinity toward D (−7.3 kcal/mol), 5HT 3 (−7.1 M 5 (−7 kcal/mol) receptors same site ligand. Conclusion research indicated that has mild properties by interacting , 5TH receptors. Therefore, preclinical clinical studies are necessary assess effectiveness safety profile this ingredient.

Язык: Английский

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Possible GABAkine‐Mediated Sedative‐Like Antidepressant Effects of Phytol: Molecular Interventions Through In Vitro, In Vivo and In Silico Approaches

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(3)

Опубликована: Март 1, 2025

A previous report suggests that phytol (PHY) may exert its antidepressant effects in mice, possibly through GABAA receptor interaction pathways. We aimed to check effect with possible molecular mechanisms behavioral and silico studies. For this, adult mice were randomly divided into different groups (n = 6), namely control (vehicle), standards (DZP: diazepam at 2 mg/kg, FLU: flumazenil 0.1 FLUX: fluoxetine 20 mg/kg), PHY (25, 50, 75 combined (PHY-75 DZP-2 and/or FLU-0.1, FLUX-20). Thirty minutes after treatment, each animal was subjected tail suspension forced swimming tests, their immobility time (IMT) counted for 5 min. In studies performed the α1, α2, α3, α5, γ2 subunits 5HT1A investigate mechanisms. Additionally, vitro GABA activity of reference drugs also by using colorimetric method. The results demonstrated DZP significantly (p < 0.05) concentration-dependently inhibited GABA, while FLU alone or combination reversed it. dose-dependently reduced IMT both protocols, FLUX-20 showed lower compared DZP, indicating elevated locomotion mice. It a value male animals than female animals. sexes, mg/kg increased values DZP-2, reducing this parameter FLU-0.1. exhibited higher binding affinities α2 α3 receptors -6.5, -7.2 6.7 kcal/mol, respectively. Taken together, exerted sedative-like modulated GABAergic serotonergic drug FLUX. be potential candidate management depression.

Язык: Английский

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