Resveratrol enhances post-injury muscle regeneration by regulating antioxidant and mitochondrial biogenesis

Current Research in Food Science, Год журнала: 2025, Номер 10, С. 100972 - 100972

Опубликована: Янв. 1, 2025

Resveratrol (RES), a natural polyphenolic compound, has shown promise in enhancing skeletal muscle regeneration and metabolic function. This study aims to explore the impact of RES on after injury through regulation antioxidant capacity mitochondrial biogenesis. treatment significantly increased ratio tibialis anterior mass body weight, alongside reduced fasting glucose levels. Following cardiotoxin-induced injury, improved regeneration, characterized by greater formation new fibers better structural repair compared control. Notably, gene expression analyses demonstrated that RES-treated mice exhibited elevated levels myogenic markers, such as paired box 7 (Pax7), factor 5 (Myf5), myoblast determination protein (MyoD), Myogenin (MyoG). Concurrently, yes-associated (YAP) increased, underscoring its role regulating satellite cell activity. Transcriptomic analysis identified enriched pathways related biogenesis, with transcription factors higher DNA content mice. Furthermore, enhanced via Kelch-like ECH-associated 1 (KEAP-1)/nuclear erythroid 2-related 2 (NRF2)/heme oxygenase-1 (HO-1) signaling pathway, indicated activities total capacity, Glutathione peroxidase (GSH-PX), superoxidase dismutase (SOD). Collectively, these findings suggest not only promotes but also supports function defenses, positioning it food-derived pharmaceutical for targeting injury.

Язык: Английский

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Resveratrol-derived carbon dots integrated into gelatin/chitosan multifunctional films for intelligent packaging

Food Chemistry X, Год журнала: 2025, Номер 25, С. 102182 - 102182

Опубликована: Янв. 1, 2025

In this study, multifunctional Resveratrol-derived carbon dots (Res-CDs) were prepared using a hydrothermal method. Res-CDs exhibited good free-radical scavenging activities, attributed to abundant surface hydroxyl groups, and effectively inhibited Staphylococcus aureus Escherichia coli growth at concentration of 2 mg/mL. Composite films by combining with gelatin/chitosan. As well as excellent mechanical properties, the smooth surfaces, thermal stability, antioxidant, ultraviolet-shielding, antibacterial, pH-responsive properties. Furthermore, cell viability measurements showed that safe. When applied keeping pork fresh, gelatin/chitosan/Res-CDs film significantly reduced total viable bacterial count on prevented discoloration. Additionally, pH, volatile basic nitrogen, weight loss confirmed preservative effects pork. This work provides new approach for synthesizing bionanocomposite applicability in food industry.

Язык: Английский

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Therapeutic Efficacy of Quercetin and Its Nanoformulation Both the Mono‐ or Combination Therapies in the Management of Cancer: An Update with Molecular Mechanisms

Journal of Tropical Medicine, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Quercetin, a major representative of the flavonol subclass found abundantly in almost all edible vegetables and fruits, showed remarkable therapeutic properties was beneficial numerous degenerative diseases by preventing lipid peroxidation. Quercetin is different diseases, such as atherosclerosis chronic inflammation. This study aims to find out anticancer activities quercetin determine mechanisms pathways which are responsible for effect. It also revealed biopharmaceutical, toxicological characteristics, clinical utilization evaluate its suitability further investigations reliable drug. All relevant data concerning this compound with cancer collected using scientific search engines, including PubMed, Springer Link, Wiley Online, Web Science, SciFinder, ScienceDirect, Google Scholar. review demonstrated that strong properties, apoptosis, inhibition cell proliferation, autophagy, cycle arrest, angiogenesis, invasion migration against various types cancer. Findings could significantly moderate regulate pathways, PI3K/AKT‐mTORC1 pathway, JAK/STAT signaling system, MAPK MMP NF‐ κ B p‐Camk2/p‐DRP1 pathway. However, poor oral bioavailability due reduced absorption; limitation overcome applying nanotechnology (nanoformulation quercetin). Moreover, expressed no toxic effect investigated subjects. Based on view these findings, it might be considered chemotherapeutic drug candidate treatment cancers. more studies suggested establish proper efficacy, safety, human dose.

Язык: Английский

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Nitrogen-doped waste biomass-derived carbon dots as fluorescent sensors for economical, green, rapid and sensitive detection of resveratrol in foods

Food Chemistry, Год журнала: 2025, Номер 472, С. 142886 - 142886

Опубликована: Янв. 13, 2025

Язык: Английский

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Chemoprevention of phytoestrogens on women hormone-related cancers by integrating text mining and data mining approaches

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106368 - 106368

Опубликована: Март 1, 2025

Язык: Английский

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Non-cytotoxic levels of resveratrol enhance the anticancer effects of cisplatin by increasing the methyltransferase activity of CARM1 in human cancer cells

Phytomedicine, Год журнала: 2024, Номер 135, С. 156127 - 156127

Опубликована: Окт. 3, 2024

Язык: Английский

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(±) Citronellal Exerts Antidepressant and Modulatory Effects on Duloxetine Possibly Through Serotonin and Norepinephrine Reuptake Interaction Pathway: In Vivo Approach with Molecular Docking

ChemistrySelect, Год журнала: 2024, Номер 9(46)

Опубликована: Дек. 1, 2024

Abstract This study aims to assess the antidepressant and modulatory activities of citronellal (CIT) on duloxetine (DUX) its possible underlying mechanisms through in vivo silico studies. Hence, forced swimming test (FST), tail suspension (TST), open field (OFT) were carried out. Mice treated with different doses CIT (50, 100, 200 mg/kg, p.o.), while DUX (15 p.o.) was used as a positive control vehicle served negative control. Additionally, molecular docking conducted evaluate binding interactions. Results demonstrated that dose‐dependently significantly ( p < 0.05) alleviated immobility time both FST TST. At dose showed notable effects times 42.17 ± 3.70 70.17 2.56 s TST, respectively. In combination therapy, (100 mg/kg) modulated activity DUX. However, is confirmed by OFT test, which reduced locomotion activity. Further, exhibited moderate affinity (−6.1 kcal/mol) toward serotonin norepinephrine reuptake transporters (SRT NRT) forming several bonds. conclusion, activity, possibly interacting SRT NRT.

Язык: Английский

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The Potential Application of Resveratrol and Its Derivatives in Central Nervous System Tumors

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13338 - 13338

Опубликована: Дек. 12, 2024

Resveratrol, a naturally occurring polyphenolic compound found in various plants, has been extensively studied for its broad spectrum of beneficial biological effects. These encompass potent antioxidant properties, anti-inflammatory activities, anti-aging capabilities, cardioprotective functions, and neuroprotective potential. The diverse actions resveratrol extend beyond these well-established properties. It also exerts significant impact on metabolic processes bioavailability, critically, it demonstrates the ability to effectively traverse blood–brain barrier. This capacity penetrate central nervous system renders promising therapeutic agent management malignancies, as shown inhibit tumor cell proliferation, induce apoptosis, modulate key signaling cascades, such PI3K/Akt, JAK/STAT, NF-kB. multifaceted nature resveratrol’s effects, including influence physiological processes, underscores potential valuable option treatment tumors.

Язык: Английский

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Mitochondria-targeted combine with methyl modification novel resveratrol derivatives enhances the anti-tumor activity

New Journal of Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Mitochondria-targeting compound A4 exerts the excellent anticancer activity by both cell cycle arrest and apoptosis induction.

Язык: Английский

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Advances in antitumor effects of pterostilbene and its derivatives

Future Medicinal Chemistry, Год журнала: 2024, Номер unknown, С. 1 - 16

Опубликована: Дек. 10, 2024

Pterostilbene (PT) is a naturally occurring small molecule stilbenoid that has garnered significant attention due to its potential therapeutic effects in tumor diseases. In this review, we conducted comprehensive analysis of the antitumor PT and derivatives on various cancer types, including colon, breast, liver, lung, pancreatic cancers recent 20 years. We have succinctly summarized exhibit superior anti-tumor efficacy compared PT. Additionally, reviewed structure-activity relationship (SAR) rules clinical application methods establish foundation for chemical modification utilization stilbene compounds.

Язык: Английский

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