Discovery of Novel Low Bee‐Toxicity Aphicidal α‐Butenolide: Design and Optimization Based on A Progressive Strategy of AChBP and ClogP DOI Open Access

Renxuan Zou,

Xiang Li,

Na Wang

и другие.

Chemistry & Biodiversity, Год журнала: 2024, Номер unknown

Опубликована: Дек. 12, 2024

The development of novel insecticides with low bee toxicity has become increasingly urgent as many high bee-toxicity neonicotinoids have been progressively restricted. In this study, halogenated phenyl-substituted α-butenolide compounds were designed, optimized and synthesized through a progressive strategy based on insect nicotinic acetylcholine receptor the calculated oil-water partition coefficient (ClogP) compounds. Among these, difluorophenyl-substituted compound 3cj (lethal medium concentration [LC

Язык: Английский

Green synthesis, characterization, and bio-efficacy of novel benzamides as insect growth regulator (IGR) analogues against Spodoptera frugiperda DOI
Hany M. Abd El‐Lateef, Mai M. Khalaf, Antar A. Abdelhamid

и другие.

Toxicological & Environmental Chemistry Reviews, Год журнала: 2025, Номер 107(3), С. 409 - 427

Опубликована: Фев. 23, 2025

According to the majority of problems caused by use insecticides, rapid enhancement resistance conventional chemical insecticide compounds is another significant impetus for creation new effective insecticidal agents. One keys meeting this challenge explore classes with diverse modes action. The safe and distinctively designed organic ingredients essential development in order reduce effects derivatives. So, we prepared that have structure analogues insect growth regulator pyriproxyfen then tested them against Spodoptera frugiperda. structures produced products were proven using elemental analysis spectroscopic results. When synthetic derivatives toxicity S. frugiperda, 4-(2-hydroxy-3-phenoxypropoxy)phenyl-1,4-bis(2E)-3-(4chlorophenyl)prop-2-en-1-one 3 showed high activity (LC50 = 26.8 mg/L) compared pyriproxyfen, while other components moderate low effectiveness. In addition to, some biological parameters, including adult longevity, pupal weight, fraction normal, deformed pupae, was also conducted. This work created a pathway identification novel class insecticides.

Язык: Английский

Процитировано

0

A Two-Step Process for the Synthesis of Densely Functionalized N-Bridged Octahydrobenzofurans and Hexahydrobenzofurans DOI
Xiaodan Han,

Pei Zhao,

Jianjun Yuan

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 2, 2025

A new process for the synthesis of densely functionalized N-bridged octahydrobenzofurans and hexahydrobenzofurans, by means a two-step protocol, is reported. The mechanism involves novel catalytic rearrangement reaction, Diels-Alder an intramolecular aza-addition cyclization. Preliminary bioassays showed that compound 3d more strongly inhibited Staphylococcus aureus, while 4d displayed excellent insecticidal activity against Spodoptera litura Fabricius.

Язык: Английский

Процитировано

0

Discovery of Novel Low Bee‐Toxicity Aphicidal α‐Butenolide: Design and Optimization Based on A Progressive Strategy of AChBP and ClogP DOI Open Access

Renxuan Zou,

Xiang Li,

Na Wang

и другие.

Chemistry & Biodiversity, Год журнала: 2024, Номер unknown

Опубликована: Дек. 12, 2024

The development of novel insecticides with low bee toxicity has become increasingly urgent as many high bee-toxicity neonicotinoids have been progressively restricted. In this study, halogenated phenyl-substituted α-butenolide compounds were designed, optimized and synthesized through a progressive strategy based on insect nicotinic acetylcholine receptor the calculated oil-water partition coefficient (ClogP) compounds. Among these, difluorophenyl-substituted compound 3cj (lethal medium concentration [LC

Язык: Английский

Процитировано

2