Green synthesis, characterization, and bio-efficacy of novel benzamides as insect growth regulator (IGR) analogues against Spodoptera frugiperda
Toxicological & Environmental Chemistry Reviews,
Год журнала:
2025,
Номер
107(3), С. 409 - 427
Опубликована: Фев. 23, 2025
According
to
the
majority
of
problems
caused
by
use
insecticides,
rapid
enhancement
resistance
conventional
chemical
insecticide
compounds
is
another
significant
impetus
for
creation
new
effective
insecticidal
agents.
One
keys
meeting
this
challenge
explore
classes
with
diverse
modes
action.
The
safe
and
distinctively
designed
organic
ingredients
essential
development
in
order
reduce
effects
derivatives.
So,
we
prepared
that
have
structure
analogues
insect
growth
regulator
pyriproxyfen
then
tested
them
against
Spodoptera
frugiperda.
structures
produced
products
were
proven
using
elemental
analysis
spectroscopic
results.
When
synthetic
derivatives
toxicity
S.
frugiperda,
4-(2-hydroxy-3-phenoxypropoxy)phenyl-1,4-bis(2E)-3-(4chlorophenyl)prop-2-en-1-one
3
showed
high
activity
(LC50
=
26.8
mg/L)
compared
pyriproxyfen,
while
other
components
moderate
low
effectiveness.
In
addition
to,
some
biological
parameters,
including
adult
longevity,
pupal
weight,
fraction
normal,
deformed
pupae,
was
also
conducted.
This
work
created
a
pathway
identification
novel
class
insecticides.
Язык: Английский
A Two-Step Process for the Synthesis of Densely Functionalized N-Bridged Octahydrobenzofurans and Hexahydrobenzofurans
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 2, 2025
A
new
process
for
the
synthesis
of
densely
functionalized
N-bridged
octahydrobenzofurans
and
hexahydrobenzofurans,
by
means
a
two-step
protocol,
is
reported.
The
mechanism
involves
novel
catalytic
rearrangement
reaction,
Diels-Alder
an
intramolecular
aza-addition
cyclization.
Preliminary
bioassays
showed
that
compound
3d
more
strongly
inhibited
Staphylococcus
aureus,
while
4d
displayed
excellent
insecticidal
activity
against
Spodoptera
litura
Fabricius.
Язык: Английский
Discovery of Novel Low Bee‐Toxicity Aphicidal α‐Butenolide: Design and Optimization Based on A Progressive Strategy of AChBP and ClogP
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 12, 2024
The
development
of
novel
insecticides
with
low
bee
toxicity
has
become
increasingly
urgent
as
many
high
bee-toxicity
neonicotinoids
have
been
progressively
restricted.
In
this
study,
halogenated
phenyl-substituted
α-butenolide
compounds
were
designed,
optimized
and
synthesized
through
a
progressive
strategy
based
on
insect
nicotinic
acetylcholine
receptor
the
calculated
oil-water
partition
coefficient
(ClogP)
compounds.
Among
these,
difluorophenyl-substituted
compound
3cj
(lethal
medium
concentration
[LC
Язык: Английский