Green synthesis, characterization, and bio-efficacy of novel benzamides as insect growth regulator (IGR) analogues against Spodoptera frugiperda

Toxicological & Environmental Chemistry Reviews, Journal Year: 2025, Volume and Issue: 107(3), P. 409 - 427

Published: Feb. 23, 2025

According to the majority of problems caused by use insecticides, rapid enhancement resistance conventional chemical insecticide compounds is another significant impetus for creation new effective insecticidal agents. One keys meeting this challenge explore classes with diverse modes action. The safe and distinctively designed organic ingredients essential development in order reduce effects derivatives. So, we prepared that have structure analogues insect growth regulator pyriproxyfen then tested them against Spodoptera frugiperda. structures produced products were proven using elemental analysis spectroscopic results. When synthetic derivatives toxicity S. frugiperda, 4-(2-hydroxy-3-phenoxypropoxy)phenyl-1,4-bis(2E)-3-(4chlorophenyl)prop-2-en-1-one 3 showed high activity (LC50 = 26.8 mg/L) compared pyriproxyfen, while other components moderate low effectiveness. In addition to, some biological parameters, including adult longevity, pupal weight, fraction normal, deformed pupae, was also conducted. This work created a pathway identification novel class insecticides.

Language: Английский

Discovery of Novel Low Bee‐Toxicity Aphicidal α‐Butenolide: Design and Optimization Based on A Progressive Strategy of AChBP and ClogP

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

The development of novel insecticides with low bee toxicity has become increasingly urgent as many high bee-toxicity neonicotinoids have been progressively restricted. In this study, halogenated phenyl-substituted α-butenolide compounds were designed, optimized and synthesized through a progressive strategy based on insect nicotinic acetylcholine receptor the calculated oil-water partition coefficient (ClogP) compounds. Among these, difluorophenyl-substituted compound 3cj (lethal medium concentration [LC

Language: Английский