Altered metabolism in cancer: insights into energy pathways and therapeutic targets
Molecular Cancer,
Год журнала:
2024,
Номер
23(1)
Опубликована: Сен. 18, 2024
Язык: Английский
Diabetes and obesity: the role of stress in the development of cancer
Endocrine,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 3, 2024
Abstract
Diabesity
is
a
condition
where
an
individual
has
both
diabetes
and
obesity,
which
can
lead
to
severe
complications
including
cardiovascular
disease,
leading
cause
of
mortality.
Recently,
cancer
become
excess
hospitalizations,
obesity
are
associated
with
higher
risk
developing
several
types
cancer.
In
this
review,
we
propose
that
chronic
stress
significantly
increases
association.
Managing
challenging
as
they
significant
distress.
The
relationship
between
interconnected,
anxiety
depression
being
common
in
patients.
Cancer
diagnosis
treatment
lasting
changes
the
body’s
neuroendocrine
system,
causing
excessive
release
catecholamines
prostaglandins
patients
undergoing
surgery,
promotes
spread
other
parts
body.
Furthermore,
could
increase
diabetes,
or
both.
Язык: Английский
RadioFlow Cytometry Reveals That [18F]FDG Uptake in K-RAS Lung Cancer Is Driven by Immune Cells: An Analysis on a Single-Cell Level
Journal of Nuclear Medicine,
Год журнала:
2025,
Номер
unknown, С. jnumed.124.268799 - jnumed.124.268799
Опубликована: Янв. 16, 2025
Tumor
metabolism
is
a
hallmark
of
cancer,
yet
cellular
heterogeneity
within
the
tumor
microenvironment
presents
significant
challenge,
as
bulk
analysis
masks
diverse
metabolic
profiles
individual
cell
populations.
This
complexity
complicates
our
understanding
[18F]FDG
uptake
by
distinct
types
in
microenvironment.
study
aims
to
investigate
at
single-cell
level
lung
Kirsten
rat
sarcoma
virus–driven
cancer
mouse
models
using
novel
technique
radio–flow
cytometry
(radioFlow).
Methods:
Two
were
injected
with
for
small-animal
PET/CT
and
subsequent
fluorescence-activated
sorting
lung.
For
radioFlow,
sorted
fractions
then
measured
γ-counter
their
radioactivity
was
normalized
number
cells.
Results:
RadioFlow
tissue
both
showed
robust
type–specific
pattern
across
experiments.
Our
key
findings
indicate
that
PET
signal
predominantly
derives
from
immune
cells
(CD45+,
F4/80−,
78.3%
±
6.6%;
macrophage,
13.9%
4.3%),
whereas
contributed
only
2.8%
1.0%,
similar
structural
(CD45−;
cells,
5.0%
2.3%).
Normalization
macrophages
exhibited
highest
glucose
(57%
8%),
followed
remaining
(27%
3%).
Conclusion:
These
highlight
critical
influence
on
imaging,
emphasizing
need
account
contributions
when
interpreting
imaging
cancer.
Язык: Английский
Beyond nutritional immunity: immune-stressing challenges basic paradigms of immunometabolism and immunology
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 12, 2025
Pathogens
have
the
well-known
advantage
of
rapid
evolution
due
to
short
generation
times
and
large
populations.
However,
pathogens
rarely
noted
disadvantage
vulnerability
stress
involved
in
proliferation
as
well
being
localized.
Presented
here
are
numerous
new
paradigms
immunology,
especially
immunometabolism,
which
derived
from
examining
how
hosts
capitalize
on
pathogen
vulnerabilities
stress.
Universally,
requires
both
resources
synthesis,
vulnerable
resource-limiting
damaging/noxious
stress,
respectively.
particularly
at
time
when
they
most
threatening-when
proliferating.
Since
immune
cells
actively
controlling
(effector
cells)
typically
do
not
proliferate
infected
sites,
there
is
a
"stress
gap"
wherein
proliferating
more
any
type
than
attacking
effector
cells.
Hosts
by
restricting
(resource-limiting
stress)
generating
noxious
waste
products
(damaging/disruptive
fundamental
defense
here-in
termed
"immune-stressing."
While
nutritional
immunity
emphasizes
denying
micronutrients,
immune-stressing
extends
concept
all
resources,
glucose
oxygen,
coupled
with
metabolic
such
lactic
acid,
reactive
oxygen
species
(ROS),
heat
further
harm
or
pathogens.
At
present
much
field
immunometabolism
centers
nutrition
metabolism
regulate
function,
central
feature
inefficient
use
via
aerobic
glycolysis
(with
lactate/lactic
acid
production)
In
contrast,
system
uses
control
infections.
Immune-stressing
addresses
cell
site
noting
that
high
uptake
linked
output
an
ideal
double-pronged
stressor
targeting
Once
basic
recognized,
other
immunology
whole,
challenged.
Язык: Английский
Plant-derived terpenoids modulating cancer cell metabolism and cross-linked signaling pathways: an updated reviews
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 28, 2025
Язык: Английский
Oleuropein Protects against the Development of Kidneys Induced by Paracetamol in Albino Male Rats.
Elham Ahmed Mejbel,
Saif Subhi Noori,
Adeeb Shakir Mahmood
и другие.
HAYATI Journal of Biosciences,
Год журнала:
2024,
Номер
32(1), С. 254 - 262
Опубликована: Ноя. 22, 2024
Paracetamol
treatment
is
considered
one
of
the
treatments
used
to
relieve
pain
and
antipyretic.
Therefore,
excessive
doses
long-term
use
lead
organ
toxicity.
The
aim
study
was
investigate
protective
effect
Oleuropein
extracted
from
olive
leaves
on
physiological
histological
aspects
induced
by
in
a
rat
model.
methods
25
albino
Swiss
rats
randomly
distributed
into
five
groups
with
same
number.
unit
control
given
normal
saline.
(750
mg/kg)
injected
group
once.
In
(50
mg/kg,
100
150
mg/kg).
Administration
Paracetamol's
result
significantly
increased
blood
urea,
creatinine,
sodium,
potassium
levels,
their
concentrations
decreased
(P
0.05).
addition,
relieved
some
symptoms,
including
acute
vascular
congestion
caused
dose
Paracetamol.
Compared
paracetamol
treatment,
there
an
infiltration
inflammatory
cells
severe
nephrotoxicity
tubules.
According
this
study,
can
be
prevent
kidney
damage,
It
not
recommended
give
Paracetamol,
which
increases
disorders.
Язык: Английский