Exosomes: Insights and therapeutic applications in cancer DOI Creative Commons

Anita Raj Panigrahi,

Srinivas Lankalapalli,

Jagadeesh Panda

и другие.

Translational Oncology, Год журнала: 2022, Номер 21, С. 101439 - 101439

Опубликована: Май 9, 2022

Cancer refers to the division of abnormal cells at an uncontrollable rate that possesses ability infiltrate and destroy normal tissues. It frequently spreads tissues throughout body, a condition known as metastasis, which is significant concern. second leading cause mortality globally treatment therapy can assist in improving survival rates. Exosomes are extracellular vesicles secreted by several act messengers between cells. When engineered, exosomes promising drug delivery vehicles help achieve targeted action tumour site reduce limitations conventional treatments such castration, chemotherapy, radiation, etc. The present review provides overview exosomes, biogenesis, sources, isolation methods characterization. current status applications chemotherapeutic agents loaded, engineered cancer were convoluted.

Язык: Английский

Potential therapeutic effects of milk-derived exosomes on intestinal diseases DOI Creative Commons
Zhifu Cui, Felix Kwame Amevor, Xingtao Zhao

и другие.

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Дек. 20, 2023

Exosomes are extracellular vesicles with the diameter of 30 ~ 150 nm, and widely involved in intercellular communication, disease diagnosis drug delivery carriers for targeted therapy. Therapeutic application exosomes as is limited due to lack sources methods obtaining adequate exosomes. Milk contains abundant exosomes, several studies have shown that milk-derived play crucial roles preventing treating intestinal diseases. In this review, we summarized biogenesis, secretion structure, current novel used extraction identification well discussed role diseases, such inflammatory bowel disease, necrotizing enterocolitis, colorectal cancer, ischemia reperfusion injury by regulating immune homeostasis, restoring gut microbiota composition improving structure integrity, alleviating conditions oxidative stress, cell apoptosis inflammation, reducing mitochondrial reactive oxygen species (ROS) lysosome accumulation both humans animals. addition, future prospects standardization milk exosome production platform obtain higher concentration purity, complete derived from milk. Several vivo clinical needed establish an effective efficient system, promote its treatment various diseases

Язык: Английский

Процитировано

22

Colon health benefits of plant-derived exosome-like nanoparticles via modulating gut microbiota and immunity DOI
Yanhui Han, Xiaojing Guo,

Z H Ji

и другие.

Critical Reviews in Food Science and Nutrition, Год журнала: 2025, Номер unknown, С. 1 - 21

Опубликована: Март 19, 2025

Exosomes are nanoscale particles with a lipid bilayer membrane that were first identified in mammalian cells. Plant-derived exosome-like nanoparticles (PELNs) share structural and molecular similarities exosomes, including lipids, proteins, microRNA (miRNA), plant-derived metabolites. Owing to their unique characteristics, such as outstanding stability, low immunogenicity, high biocompatibility, sustainability, PELNs have emerged promising natural bioactive agents the capacity for cross-kingdom cellular regulation. Dietary supplementation PELNs, particularly from fruits vegetables, has demonstrated health benefits. An increasing number of studies indicated beneficial effects on colon health. This review summarizes isolation characterization uptake, distribution after oral ingestion. Furthermore, this emphasizes interactions between gut microbiota, immune system, uptake by modulation bacteria metabolism, responses PELNs. Additionally, applications components drug carriers targeting reviewed. In summary, represent versatile approach improve health, potential both therapeutic preventive healthcare strategies.

Язык: Английский

Процитировано

1

Isolation of circulating exosomes and identification of exosomal PD-L1 for predicting immunotherapy response DOI
Junli Zhang, Yifan Zhu,

Mengting Guan

и другие.

Nanoscale, Год журнала: 2022, Номер 14(25), С. 8995 - 9003

Опубликована: Янв. 1, 2022

Exosomes, a subgroup of extracellular vesicles secreted by multiple cells, have great potential as cancer biomarkers in clinical applications. However, enrichment and detection exosomes from complex media remain huge challenge due to their small size. Herein, we used iodixanol density gradient centrifugation for the isolation purification label-free exosomal PD-L1 using biochip based on surface plasmon resonance (SPR-ExoPD-L1). The obtained are lipid-bilayer classical exosome markers CD9, CD63 CD81 highly enriched. Besides, is specifically expressed instead non-vesicular components or large vesicles. Compared with enzyme-linked immunosorbent assays, SPR-ExoPD-L1 assay could better distinguish derived melanoma cells different levels PD-L1. Accurate measurement provide critical information diagnosis personalized immunotherapy cancer.

Язык: Английский

Процитировано

29

Exosome derived from stem cell: A promising therapeutics for wound healing DOI Creative Commons
Hui Lv, Hanxiao Liu, Ting Sun

и другие.

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Авг. 8, 2022

A wound occurs when the epidermis and dermis of skin are damaged internally externally. The traditional healing method is unsatisfactory, which will prolong treatment time increase cost, brings economic psychological burdens to patients. Therefore, there an urgent need for a new accelerate healing. As cell-free therapy, exosome derived from stem cell (EdSC) offers possibilities EdSC smallest extracellular vesicle secreted by cells with diameters 30-150 nm lipid bilayer structure. Previous studies have found that can participate in promote almost all stages healing, including regulating inflammatory cells; improving activation fibroblasts, keratinocytes, endothelial adjusting ratio collagen Ⅰ Ⅲ. We reviewed relevant knowledge wounds; summarized biogenesis, isolation, identification exosomes; clarified pharmacological role exosomes promoting This review provides support study exosomes.

Язык: Английский

Процитировано

26

Exosomes: Insights and therapeutic applications in cancer DOI Creative Commons

Anita Raj Panigrahi,

Srinivas Lankalapalli,

Jagadeesh Panda

и другие.

Translational Oncology, Год журнала: 2022, Номер 21, С. 101439 - 101439

Опубликована: Май 9, 2022

Cancer refers to the division of abnormal cells at an uncontrollable rate that possesses ability infiltrate and destroy normal tissues. It frequently spreads tissues throughout body, a condition known as metastasis, which is significant concern. second leading cause mortality globally treatment therapy can assist in improving survival rates. Exosomes are extracellular vesicles secreted by several act messengers between cells. When engineered, exosomes promising drug delivery vehicles help achieve targeted action tumour site reduce limitations conventional treatments such castration, chemotherapy, radiation, etc. The present review provides overview exosomes, biogenesis, sources, isolation methods characterization. current status applications chemotherapeutic agents loaded, engineered cancer were convoluted.

Язык: Английский

Процитировано

25