Nature Communications, Год журнала: 2025, Номер 16(1)
Опубликована: Апрель 19, 2025
Язык: Английский
EClinicalMedicine, Год журнала: 2023, Номер 64, С. 102193 - 102193
Опубликована: Сен. 9, 2023
The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific rarely studied. study aims to investigate pattern trend 1990 2019.We collected detailed information on six major IMIDs, including asthma, bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, atopic dermatitis, between 2019, derived Global Burden Disease in 2019. average annual percent change (AAPC) number incidents age standardized rate (ASR) by sex, age, region, causes, were calculated quantify temporal trends.In disease accounted 1.59%, 36.17%, 54.71%, 0.09%, 6.84%, 0.60% overall new cases, respectively. ASR showed substantial regional global variation with highest High SDI High-income North America, United States America. Throughout human lifespan, distribution incident cases was quite different. Globally, increased an AAPC 0.68 decreased -0.34 across arthritis (0.21, 95% CI 0.18, 0.25), while asthma (AAPC = -0.41), -0.72), sclerosis -0.26), psoriasis -0.77), dermatitis -0.15) decreased. individual IMID at level. Countries higher experienced a more rapid decrease ASR.The patterns varied considerably world. Innovative prevention integrative management strategy urgently needed mitigate increasing upsurging other five respectively.The Study is funded Bill Melinda Gates Foundation. project Scientific Research Fund Sichuan Academy Medical Sciences & Provincial People's Hospital (2022QN38).
Язык: Английский
Процитировано
70
BioNanoScience, Год журнала: 2023, Номер 13(2), С. 840 - 852
Опубликована: Апрель 15, 2023
Язык: Английский
Процитировано
67
Cell Biology International, Год журнала: 2022, Номер 46(9), С. 1320 - 1344
Опубликована: Июль 13, 2022
Abstract Immune‐mediated diseases (IMDs) are chronic conditions that have an immune‐mediated etiology. Clinically, these appear to be unrelated, but pathogenic pathways been shown connect them. While inflammation is a common occurrence in the body, it may either stimulate favorable immune response protect against harmful signals or cause illness by damaging cells and tissues. Nanomedicine has tremendous promise for regulating treating IMIDs. Various nanoparticles coated with nanotherapeutics recently fabricated effective targeted delivery inflammatory RNA interference (RNAi) offers genetic approach, particularly if traditional treatments ineffective IMDs. In cells, several signaling can suppressed using RNAi, which blocks expression of particular messenger RNAs. Using this molecular undesirable effects anti‐inflammatory medications reduced. Still, there many problems short‐interfering RNAs (siRNAs) treat IMDs, including poor localization siRNAs target tissues, unstable gene expression, quick removal from blood. Nanotherapeutics widely used designing siRNA‐based carriers because restricted therapy options review, we discussed recent trends fabrication siRNA nanodelivery systems, lipid‐based nanocarriers, liposomes, cationic lipids, stable nucleic acid‐lipid particles, polymeric‐based polyethylenimine (PEI)‐based nanosystems, chitosan‐based nanoformulations, inorganic material‐based hybrid‐based systems. We also introduced novel nanocarriers control IMIDs, such as pulmonary inflammation, psoriasis, bowel disease, ulcerative colitis, rheumatoid arthritis, etc. This study will pave way new avenues research into diagnosis treatment
Язык: Английский
Процитировано
44
European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 259, С. 115676 - 115676
Опубликована: Июль 23, 2023
Язык: Английский
Процитировано
44
Inorganic Chemistry Communications, Год журнала: 2023, Номер 155, С. 110999 - 110999
Опубликована: Июнь 29, 2023
Язык: Английский
Процитировано
38
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 87, С. 104774 - 104774
Опубликована: Июль 20, 2023
Huntington's disease (HD) is a neurological disorder characterized by reduction in medium-spiny neurons the brain. Currently, there no cure for HD and treatment relies on symptomatic therapy. The generation of stem cells, including neural, mesenchymal, pluripotent, through conventional strategies or direct cell reprogramming has revolutionized therapy research. Due to their unique ability differentiate into variety self-renew, grow, cells have become an area interest treating various complex unresolved neurodegenerative disorders. Nanotechnology emerged as novel approach with great potential reduced side effects. Nanoparticles (NPs) can act nanovehicles delivering therapeutic agents, siRNAs, neurotrophic factors, different drugs. Additionally, NPs be used alternative based antioxidant reactive oxygen species (ROS)-scavenging properties that protect neuronal cells. Some even exhibit interfere protein aggregation mutant Huntingtin proteins during processes. This review focuses most studied HD, polymeric, lipid-based, liposomes, solid lipid metal/metal oxide. combination diagnosis treatment. been manage cellular microenvironment, improve efficiency drug delivery brain enhance transplant survival. Understanding characteristics essential applying them purposes. In this study, biology well benefits drawbacks using its are discussed.
Язык: Английский
Процитировано
34
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 86, С. 104642 - 104642
Опубликована: Июнь 7, 2023
Язык: Английский
Процитировано
32
Pharmaceuticals, Год журнала: 2023, Номер 16(9), С. 1283 - 1283
Опубликована: Сен. 11, 2023
The processes used by academic and industrial scientists to discover new drugs have recently experienced a true renaissance, with many exciting techniques being developed over the past 5-10 years alone. Drug design discovery, search for safe well-tolerated compounds, as well ineffectiveness of existing therapies, society's insufficient knowledge concerning prophylactics pharmacotherapy most common diseases today, comprise serious challenge. This can influence not only quality human life, but also health whole societies, which became evident during COVID-19 pandemic. In general, process drug development consists three main stages: preclinical using cell-based animal models/tests, clinical trials on humans and, finally, forward moving toward step obtaining regulatory approval, in order market potential drug. this review, we will attempt outline first important consecutive phases development, based experience cooperating complementary centers Visegrád group; i.e., Medical University Lublin, Poland, Masaryk Brno, Czech Republic, Comenius Bratislava, Slovak Republic.
Язык: Английский
Процитировано
28
Advanced Healthcare Materials, Год журнала: 2023, Номер 12(19)
Опубликована: Март 16, 2023
Abstract Inflammatory bowel disease (IBD), a chronic and recurrent gastrointestinal inflammatory disorder with variety of painful clinical manifestations an increased risk cancerization or death, has become emerging challenge to global healthcare due its rapidly increasing incidence. At present, there is no efficient cure against IBD because the elusive etiology pathogenesis IBD. Therefore, development alternative therapeutic strategies positive efficacy reduced side effects urgently needed. In recent years, great prosperity nanomedicine promoted by advanced nanomaterials redefining more attractive promising for owing their advantages in physiological stability, bioavailability, targeting sites. this review, firstly basic characteristics healthy intestinal microenvironments are presented. Then, different administration routes nanotherapeutics treatment reviewed. Subsequently, specific focus placed on introduction nanotherapeutic treatments based pathogenesis. Finally, some future challenges perspectives currently developed nanomedicines provided. It believed that above topics will attract researchers from various fields including medicine, biological sciences, materials, chemistry pharmaceutics.
Язык: Английский
Процитировано
26
Nanoscale, Год журнала: 2024, Номер 16(8), С. 3881 - 3914
Опубликована: Янв. 1, 2024
The long noncoding RNAs (lncRNAs) comprise a wide range of RNA species whose length exceeds 200 nucleotides, which regulate the expression genes and cellular functions in organisms.
Язык: Английский
Процитировано
13