Next Nanotechnology,
Год журнала:
2023,
Номер
2, С. 100018 - 100018
Опубликована: Июнь 1, 2023
6-Mercaptopurine
is
a
medication
employed
to
treat
autoimmune
illnesses
and
cancer.
However,
due
its
poor
solubility,
quick
metabolism,
possible
side
effects,
it
not
very
effective.
With
advantages
like
better
bioavailability,
increased
drug
stability,
targeted
deliveries,
nanomaterials
have
emerged
as
promising
platform
for
delivery.
This
article
addresses
the
possibility
of
treating
cancer
with
based
on
mercaptopurine.
Scientists
investigated
variety
treatments,
including
use
mercaptopurine,
since
disease
one
leading
causes
death
in
globe.
The
has
been
tested
an
adjuvant
treatment
colorectal
shown
cause
remission
patients
acute
lymphoblastic
leukemia.
Due
their
capacity
boost
uptake
by
cells,
protect
from
degradation,
lessen
toxicity
healthy
tissues,
liposomes,
dendrimers,
solid
lipid
nanoparticles
potential
mercaptopurine-based
nanomaterials,
gold
nanoparticles,
discussed
several
studies
reviewed
piece.
review
provides
researchers
latest
progress
6-mercaptopurine
loaded
nanocarriers
novel
approach
utilizing
delivery
Mercaptopurine
therapy
which
show
great
advanced
tool
compared
classic
mercaptopurine
drug.
Plant Nano Biology,
Год журнала:
2024,
Номер
8, С. 100070 - 100070
Опубликована: Апрель 16, 2024
This
article
examines
the
viability
of
utilizing
plant
biomolecules
in
environmentally
sustainable
synthesis
copper
nanoparticles
(Cu
NPs).
By
harnessing
their
intrinsic
capabilities
reduction
and
capping,
plants
present
an
friendly
economically
viable
substitute
for
conventional
techniques.
Through
manipulation
diverse
parameters
throughout
procedure,
scientists
are
capable
attaining
Cu
NPs
desired
shapes
sizes,
thereby
customizing
them
to
suit
particular
applications.
review
centers
on
owing
its
cost-effectiveness
comparison
other
frequently
utilized
metals
such
as
gold
silver.
It
explores
mechanisms
that
govern
NPs.
We
conduct
exhaustive
analysis
wide-ranging
medical
healthcare
applications,
emphasizing
capacity
fundamentally
transform
numerous
treatment
approaches.
Furthermore,
offers
valuable
perspectives
alternative
techniques,
facilitating
a
comparative
evaluation
enabling
well-informed
choices
be
made
regarding
integration
knowledge
methods,
wide
range
practical
implementations,
economic
factors,
objective
this
is
furnish
asset
scientists,
researchers,
practitioners
who
investigating
propel
progress.
Nanoscale,
Год журнала:
2024,
Номер
16(8), С. 3881 - 3914
Опубликована: Янв. 1, 2024
The
long
noncoding
RNAs
(lncRNAs)
comprise
a
wide
range
of
RNA
species
whose
length
exceeds
200
nucleotides,
which
regulate
the
expression
genes
and
cellular
functions
in
organisms.
Materials Today Communications,
Год журнала:
2024,
Номер
39, С. 108724 - 108724
Опубликована: Март 24, 2024
Cancer
remains
a
global
health
challenge,
with
current
treatments
often
leading
to
adverse
side
effects.
Herein,
pH-sensitive,
biocompatible
nanocomposite
composed
of
chitosan
(CS),
polyacrylic
acid
(PAA),
and
MoS2
nanosheets,
loaded
quercetin
(QCT)
as
model
anticancer
drug
has
been
synthesized
via
the
water-oil-water
(W/O/W)
emulsification
method,
aim
be
used
for
targeted
breast
cancer
treatment.
Characterization
Fourier-transform
infrared
spectroscopy
(FT-IR)
revealed
strong
interaction
between
polymers
hydrogen
bonding,
X-ray
diffraction
(XRD)
showed
reduction
in
level
crystallinity
upon
loading.
Dynamic
light
scattering
(DLS),
zeta
potential,
field-emission
scanning
electron
microscopy
(FE-SEM)
tests
that
nanocarriers
were
spherical
shape
had
hollow
structure,
mean
size
484
nm
high
potential
+44.3
mV,
which
confirms
their
colloidal
stability.
The
addition
nanosheets
polymeric
mixture
increased
loading
encapsulation
efficiency
47%
89%,
respectively.
pH-responsive
delivery
system,
releasing
97%
68%
QCT
acidic
neutral
environments,
respectively,
over
96
hours.
biological
performance
was
investigated
using
MTT
flow
cytometry
assays,
confirmed
tumor
cell
removal.
