Frontiers in Chemistry,
Год журнала:
2023,
Номер
11
Опубликована: Март 16, 2023
Quinazolines
are
a
class
of
nitrogen-containing
heterocyclic
compounds
with
broad-spectrum
pharmacological
activities.
Transition-metal-catalyzed
reactions
have
emerged
as
reliable
and
indispensable
tools
for
the
synthesis
pharmaceuticals.
These
provide
new
entries
into
pharmaceutical
ingredients
continuously
increasing
complexity,
catalysis
these
metals
has
streamlined
several
marketed
drugs.
The
last
few
decades
witnessed
tremendous
outburst
transition-metal-catalyzed
construction
quinazoline
scaffolds.
In
this
review,
progress
achieved
in
quinazolines
under
transition
metal-catalyzed
conditions
summarized
reports
from
2010
to
date
covered.
This
is
presented
along
mechanistic
insights
each
representative
methodology.
advantages,
limitations,
future
perspectives
through
such
also
discussed.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(11), С. 4386 - 4464
Опубликована: Янв. 1, 2022
The
emerging
field
of
organometallic
catalysis
has
shifted
towards
research
on
Earth-abundant
transition
metals
due
to
their
ready
availability,
economic
advantage,
and
novel
properties.
In
this
case,
manganese,
the
third
most
abundant
transition-metal
in
Earth's
crust,
emerged
as
one
leading
competitors.
Accordingly,
a
large
number
molecularly-defined
Mn-complexes
been
synthesized
employed
for
hydrogenation,
dehydrogenation,
hydroelementation
reactions.
regard,
catalyst
design
is
based
three
pillars,
namely,
metal-ligand
bifunctionality,
ligand
hemilability,
redox
activity.
Indeed,
developed
catalysts
not
only
differ
chelating
atoms
they
possess
but
also
working
principles,
thereby
different
turnover
numbers
product
molecules.
Hence,
critical
assessment
molecularly
defined
manganese
terms
atoms,
reaction
conditions,
mechanistic
pathway,
significant.
Herein,
we
analyze
complexes
catalytic
activity,
versatility
allow
multiple
transformations
routes
convert
substrates
target
This
article
will
be
helpful
get
significant
insight
into
design,
aiding
design.
Organic Chemistry Frontiers,
Год журнала:
2021,
Номер
8(11), С. 2673 - 2709
Опубликована: Янв. 1, 2021
In
this
review,
we
have
summarized
various
aspects
of
homogeneous
and
heterogeneously
catalyzed
recent
advancements
in
the
synthesis
heterocycles
following
ADC
approach.
Chemical Reviews,
Год журнала:
2024,
Номер
124(9), С. 6078 - 6144
Опубликована: Апрель 17, 2024
Alcohols
are
abundant
and
attractive
feedstock
molecules
for
organic
synthesis.
Many
methods
their
functionalization
require
them
to
first
be
converted
into
a
more
activated
derivative,
while
recent
years
have
seen
vast
increase
in
the
number
of
complexity-building
transformations
that
directly
harness
unprotected
alcohols.
This
Review
discusses
how
transition
metal
catalysis
can
used
toward
this
goal.
These
broadly
classified
three
categories.
Deoxygenative
functionalizations,
representing
derivatization
C–O
bond,
enable
alcohol
act
as
leaving
group
formation
new
C–C
bonds.
Etherifications,
characterized
by
O–H
represent
classical
reactivity
has
been
modernized
include
mild
reaction
conditions,
diverse
partners,
high
selectivities.
Lastly,
chain
reactions
described,
wherein
acts
mediator
formal
C–H
alkyl
backbone.
Each
these
classes
transformation
will
discussed
context
intermolecular
arylation,
alkylation,
related
reactions,
illustrating
alcohols
harnessed
Catalysts,
Год журнала:
2020,
Номер
10(7), С. 773 - 773
Опубликована: Июль 11, 2020
Our
planet
urgently
needs
sustainable
solutions
to
alleviate
the
anthropogenic
global
warming
and
climate
change.
Homogeneous
catalysis
has
potential
play
a
fundamental
role
in
this
process,
providing
novel,
efficient,
at
same
time
eco-friendly
routes
for
both
chemicals
energy
production.
In
particular,
pincer-type
ligation
shows
promising
properties
terms
of
long-term
stability
selectivity,
as
well
allowing
mild
reaction
conditions
low
catalyst
loading.
Indeed,
pincer
complexes
have
been
applied
plethora
chemical
processes,
such
hydrogen
release,
CO2
capture
conversion,
N2
fixation,
biomass
valorization
synthesis
high-value
fuels.
work,
we
show
main
advances
last
five
years
use
transition
metal
key
catalytic
processes
aiming
more
ACS Catalysis,
Год журнала:
2021,
Номер
11(5), С. 2786 - 2794
Опубликована: Фев. 15, 2021
Herein
we
report
the
synthesis
of
primary
and
secondary
amines
by
nitrile
hydrogenation,
employing
a
borrowing
hydrogenation
strategy.
A
class
phosphine-free
manganese(I)
complexes
bearing
sulfur
side
arms
catalyzed
reaction
under
mild
conditions,
where
ammonia–borane
is
used
as
source
hydrogen.
The
synthetic
protocol
chemodivergent,
final
product
either
or
amine,
which
can
be
controlled
changing
catalyst
structure
polarity
medium.
significant
advantage
this
method
that
operates
without
externally
added
base
other
additives
well
obviates
use
high-pressure
dihydrogen
gas
required
for
reactions.
Utilizing
method,
wide
variety
symmetric
asymmetric
were
synthesized
in
high
yields.
mechanistic
study
involving
kinetic
experiments
high-level
DFT
computations
revealed
both
outer-sphere
dehydrogenation
inner-sphere
predominantly
operative
catalytic
cycle.
Chemical Communications,
Год журнала:
2021,
Номер
57(69), С. 8534 - 8549
Опубликована: Янв. 1, 2021
Manganese
catalyzed
hydrogen
transfer
reactions
enabled
net
reductions
and
cascade
CC-
CN-bond
formation
reactions.
The
success
is
aided
by
multifunctional
ligand
design
namely
metal–ligand
bifunctionality,
hemilability,
redox
non-innocence.
Organic Letters,
Год журнала:
2021,
Номер
23(3), С. 869 - 875
Опубликована: Янв. 21, 2021
Herein,
a
phosphine-free
pincer
ruthenium(III)
catalyzed
β-alkylation
of
secondary
alcohols
with
primary
to
α-alkylated
ketones
and
two
different
β-branched
are
reported.
Notably,
this
transformation
is
environmentally
benign
atom
efficient
H2O
H2
gas
as
the
only
byproducts.
The
protocol
extended
gram-scale
reaction
for
functionalization
complex
vitamin
E
cholesterol
derivatives.
