European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 30, 2024
Abstract
Phase‐transfer
catalysts
(PTCs)
are
chemical
agents
that
facilitate
the
transfer
of
molecules
or
ions
between
different
reaction
phases,
thereby
accelerating
heterogeneous
processes.
Transition
metal
renowned
for
their
versatility
in
breaking
inert
bonds
and
forming
new
carbon‐carbon
bonds.
Over
past
two
decades,
integrating
with
phase‐transfer
has
emerged
as
a
highly
valuable
adaptable
strategy
modern
organic
synthesis.
This
combined
catalytic
approach
highlights
enhanced
synthetic
capabilities
demonstrates
benefits
merging
these
systems.
review
provides
an
overview
recent
advancements
asymmetric
catalysis
utilize
synergy
catalysts,
focusing
on
role
rapid
efficient
synthesis
complex
precise
stereochemistry.
Organic Letters,
Год журнала:
2024,
Номер
26(33), С. 6961 - 6965
Опубликована: Авг. 9, 2024
We
report
an
unprecedented
application
of
skipped
enynes
as
bis-electrophiles
under
palladium/Brønsted
acid
catalysis.
A
[3
+
3]
annulation
with
4-hydroxy
coumarins
bis-nucleophiles
enables
a
completely
atom-economic
synthesis
fused
O-heterocycles.
The
reaction
is
proposed
to
proceed
via
the
Pd-catalyzed
C-H
activation
enyne
leading
diene,
which
upon
subsequent
by
Pd
and
O-nucleophilic
attack
leads
regioselective
formation
six-membered
heterocyclic
ring,
vinyl
substituent.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 2, 2024
Understanding
the
nature
of
a
transition-metal-catalyzed
process,
including
catalyst
evolution
and
real
active
species,
is
rather
challenging
yet
great
importance
for
rational
design
development
novel
catalysts,
this
even
more
difficult
bimetallic
catalytic
system.
Pd(0)/carboxylic
acid
combined
system-catalyzed
allylic
alkylation
reaction
alkynes
has
been
used
as
an
atom-economical
protocol
synthesis
products.
However,
asymmetric
version
still
limited,
in-depth
understanding
Pd
species
elusive.
Herein
we
report
enantioselective
coupling
between
readily
available
aldimine
esters
using
synergistic
Cu/Pd
system,
affording
diverse
set
α-quaternary
allyl
amino
ester
derivatives
in
good
yields
with
excellent
enantioselectivities.
Mechanistic
studies
indicated
that
it
most
likely
molecular
Cu
catalysis
nanoparticle
catalysis.
The
precursor
transformed
to
soluble
nanoparticles
Angewandte Chemie,
Год журнала:
2023,
Номер
135(30)
Опубликована: Май 25, 2023
Abstract
Hydrofunctionalization
of
alkynes
is
one
the
most
efficient
ways
to
access
axially
chiral
styrenes
with
open‐chained
olefins.
While
great
advances
have
been
achieved
for
1‐alkynylnaphthalen‐2‐ols
and
analogues,
atroposelective
hydrofunctionalization
unactivated
internal
lags.
Herein
we
reported
a
platinum‐catalyzed
hydrosilylation
first
time.
With
monodentate
TADDOL‐derived
phosphonite
L1
used
as
ligand,
various
were
in
excellent
enantioselectivities
high
E
‐selectivities.
Control
experiments
showed
that
N
H‐arylamide
groups
significant
effects
on
both
yields
could
act
directing
groups.
The
potential
utilities
products
shown
by
transformations
amide
motifs
products.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 30, 2024
Abstract
Phase‐transfer
catalysts
(PTCs)
are
chemical
agents
that
facilitate
the
transfer
of
molecules
or
ions
between
different
reaction
phases,
thereby
accelerating
heterogeneous
processes.
Transition
metal
renowned
for
their
versatility
in
breaking
inert
bonds
and
forming
new
carbon‐carbon
bonds.
Over
past
two
decades,
integrating
with
phase‐transfer
has
emerged
as
a
highly
valuable
adaptable
strategy
modern
organic
synthesis.
This
combined
catalytic
approach
highlights
enhanced
synthetic
capabilities
demonstrates
benefits
merging
these
systems.
review
provides
an
overview
recent
advancements
asymmetric
catalysis
utilize
synergy
catalysts,
focusing
on
role
rapid
efficient
synthesis
complex
precise
stereochemistry.
