Rongalite as a Methylene Surrogate: Synthesis of Heterodiarylmethanes via C(sp²)-H Functionalization

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 2, 2024

An efficient method for the synthesis of heterodiarylmethanes through coupling imidazo[1,2-a]pyridines and heteroarenes using indoles employing rongalite as a methylenating reagent has been developed. This regioselective C–H functionalization provides wide range imidazo[2,1-b]thiazole. Here, plays crucial role in generating C1 unit situ, which triggers heterodiarylmethylation process. The use inexpensive (ca. $0.03/1 g), mild reaction conditions, gram-scale are some key features this methodology.

Язык: Английский

Recent advances in the synthesis of nitrogen-containing heterocyclic compounds via multicomponent reaction and their emerging biological applications: a review

Journal of the Iranian Chemical Society, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Язык: Английский