RSC Advances, Год журнала: 2024, Номер 14(54), С. 39844 - 39857
Опубликована: Янв. 1, 2024
Supercritical fluid-based methods have been receiving increasing popularity in the production of pharmaceutical nanoparticles due to their ability control size and distribution particles offer high purity products.
Язык: Английский
Case Studies in Thermal Engineering, Год журнала: 2024, Номер 61, С. 105074 - 105074
Опубликована: Сен. 1, 2024
The complete investigation of the solubility Ceftriaxone sodium drug has not yet been conducted. This communication investigates in supercritical CO2 (SC-CO2) for first time. measurements were performed using utilizing UV-vis analysis under different operation conditions (at P (bar) = 120-270 and T (K) 308-338). results demonstrated that ranged from 0.90 × 10-6 to 8.01 10-6. mole fraction increases proportionally with an increase pressure, while maintaining a constant temperature. However, crossover was noted. behavior SC-CO2 modeled by Peng-Robinson equation state (PR EoS) Kwak-Mansoori van der Waals mixing rules seven semi-empirical correlations (Bian et al., Kumar-Johnston, Chrastil, Garlapati-Madras, Bartle Sung-Shim Sodeifian al.,). vaporization, total solvation enthalpies sodium/SC-carbon dioxide system obtained KJ, al. correlations. evaluation two methods absolute average relative deviation (AARD%). Both models exhibited satisfactory level agreement experimental data. Finally, PR/KM EoS Chrastil models, AARD% values 8.70% 8.10% respectively, showed superior precision accurately fitting
Язык: Английский
Процитировано
9
Journal of Chemical & Engineering Data, Год журнала: 2025, Номер unknown
Опубликована: Янв. 15, 2025
This study investigates the solubility of Baclofen in supercritical CO2, which is essential for developing an efficient drug delivery system using processes. Solubility measurements were carried out both with and without presence various cosolvents (ethanol dimethyl sulfoxide (DMSO)), across a temperature range 308–338 K pressure 12–30 MPa. exhibited ranging from 1.62 × 10–5 to 2.30 mole fractions pure CO2. In cosolvents, increased 5.76 12.79 ethanol 3.50 7.02 DMSO. Indeed, addition DMSO by approximately 3.55–5.56 times 2.15–3.05 times, respectively. Several density-based empirical models thermodynamic (Soave–Redlich–Kwong (SRK) Peng–Robinson (PR) equations state) used correlate data. Jafari Nejad's model CO2–Baclofen Jouyban's CO2–ethanol/DMSO–Baclofen systems displayed higher consistency. Also, PR showed better accuracy correlating while SRK outperformed CO2–ethanol/DMSO cosolvents. Moreover, machine learning exceptional accuracy, over 99% predictions closely matching experimental data, emphasizing its outstanding performance.
Язык: Английский
Процитировано
1
Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 127125 - 127125
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Journal of CO2 Utilization, Год журнала: 2024, Номер 91, С. 102995 - 102995
Опубликована: Дек. 15, 2024
Процитировано
6
International Journal of Pharmaceutics, Год журнала: 2024, Номер 664, С. 124579 - 124579
Опубликована: Авг. 11, 2024
Язык: Английский
Процитировано
4
Journal of Molecular Liquids, Год журнала: 2024, Номер 411, С. 125765 - 125765
Опубликована: Авг. 13, 2024
Язык: Английский
Процитировано
4
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 6, 2025
The production of fine particles by green technology like supercritical carbon dioxide requires the assessment substantial solubility data at high pressures. This study represents first determination methyldopa in pressures and temperatures ranging from 12 to 30 MPa 313.2 343.2 K, respectively. mole fractions were obtained under aforementioned conditions ranged 0.805 × 10⁻5 11.345 10⁻5. Four empirical models (Chrastil, Bartle et al., Mendez-Santiago, & Teja, Kumar-Johnston) two equations state (Peng-Robinson Soave-Redlich-Kwong) used correlate drug solubility. K-J model demonstrated highest accuracy, with an AARD 8.38% a R2 value 0.988. Furthermore, enthalpy values for SC-CO₂ estimated using Chrastil models, resulting 34.35 56.87 kJ·mol⁻¹, results demonstrate that SRK more pronounced than PR model, AARD% 23.03 0.903 compared 26.42 0.837. article's conclusions provide valuable reference application method methyldopa.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 31, 2025
In this study, the solubility of mesalazine in supercritical carbon dioxide with and without cosolvent was carried out for first time at different temperatures pressure values ranging from 308 to 338 K 12 30 MPa, respectively. The determined experimental molar solubilities were range 4.41 × 10-5 9.97 (308 K), 3.9 13.1 (318 3.4 16 (328 K) 3.3 18.4 (338 K). Meanwhile, using 2% dimethyl sulfoxide as 28.22 36.2 26.07 51.41 25.02 69.07 25.86 82.6 A novel association model employed simulate data binary ternary systems. Various semiempirical correlations utilized calculate dioxide. new deemed most superior model, achieving an average absolute relative deviation value 4.13% a cosolvent, 3.36% when included.
Язык: Английский
Процитировано
0
Chemical Engineering & Technology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 27, 2025
Abstract Solubilities of solid drugs in supercritical fluids were well represented by density models and mathematical models. In literature, several solubility reported, some them observed to be redundant according Gibbs phase rule. Therefore, the present work is aimed address nature recasting existing with help equation state (EoS). Solubility proposed Adachi–Lu, Garlapati–Madras, Keshmiri et al., Si‐Moussa Belghait Sodeifian al. model 1, 2 considered for study. Existing recast versions evaluated literature reported 20 drug compound's data carbon dioxide.
Язык: Английский
Процитировано
0
The Journal of Supercritical Fluids, Год журнала: 2025, Номер unknown, С. 106605 - 106605
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0